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https://observatorio.fm.usp.br/handle/OPI/10048
Title: | ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction |
Authors: | OLIVEIRA, Raquel de; MORAES, Tamiris Invencioni; CERDA, Alvaro; HIRATA, Mario Hiroyuki; FAJARDO, Cristina Moreno; SOUSA, Marcela Correia; DOREA, Egidio Lima; BERNIK, Myrcia Martins Silveira; HIRATA, Rosario Dominguez Crespo |
Citation: | DIABETOLOGY & METABOLIC SYNDROME, v.7, article ID 34, 9p, 2015 |
Abstract: | Background: Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients. Methods: Anthropometric and body composition parameters were measured in 249 Brazilian subjects (30 to 68 yr). Metabolic and inflammatory markers and adipokines were analyzed in blood samples. ADIPOQ rs2241766 (45 T > G) and IL6 rs1800795 (-174G > C) polymorphisms were analyzed by real-time PCR and PCR-RFLP, respectively. Results: Type 2 diabetes, hypertension, dyslipidemia and increased values of waist circumference, body fat, leptin, fibrinogen, IL-1 beta, hsCRP and TNF alpha were related to obesity (p < 0.05). Multiple linear regression analysis showed a positive correlation between BMI and waist circumference, body fat, leptin, fibrinogen, PAI-1, IL-1 beta, hsCRP and TNF alpha values (p < 0.001) but not with adiponectin. Obese group had altered metabolic status, resistance to leptin and insulin, and atherogenic and pro-inflammatory profiles. ADIPOQ and IL6 variants were not directely related to obesity, leptin resistance or alterations in cardiometabolic markers. Individuals carrying ADIPOQ 45G allele (TG + GG genotype) had higher IL-6, IL-1 beta and TNF alpha levels than TT genotype carriers (p < 0.05). IL6 -174GG genotype was associated with increased IL-1 beta levels (p = 0.033). Conclusion: Obesity is associated with leptin resistance, cardiometabolic alterations and a pro-inflammatory status. Our results are suggestive that ADIPOQ and IL6 polymorphisms contribute to cardiometabolic risk in obese individuals. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - ODS/03 |
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