Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/1065
Title: Inhibition of cPLA(2) and sPLA(2) Activities in Primary Cultures of Rat Cortical Neurons by Centella asiatica Water Extract
Authors: DEFILLIPO, Patricia P.RAPOSO, Andre H.FEDOCE, Alessandra C.FERREIRA, Aline S.POLONINI, Hudson C.GATTAZ, Wagner F.RAPOSO, Nadia R. B.
Citation: NATURAL PRODUCT COMMUNICATIONS, v.7, n.7, p.841-843, 2012
Abstract: Leaf extract of Centella asiatica has been used as an alternative medicine for memory improvement in the Indian Ayurvedic system of medicine for a long time. Although several studies have revealed its effect in ameliorating the cognitive impairment in rat models of Alzheimer's disease, the molecular mechanism of C. asiatica on neuroprotection still remains unexplained. In this study, we investigated the effects of C. asiatica water extract on activity of subtypes of phospholipase A(2) (PLA(2)) in primary cultures of rat cortical neurons and quantified by HPLC a possible molecule responsible for the activity. The cPLA(2) and sPLA(2) activities were inhibited in vitro by asiaticoside present in the water extract of C. asiatica. This extract may be a candidate for the treatment of neurodegenerative processes because of its pharmacological activity in the brain and its low toxicity, as attested by its long popular use as a natural product.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MPS
Departamento de Psiquiatria - FM/MPS

Artigos e Materiais de Revistas Científicas - LIM/27
LIM/27 - Laboratório de Neurociências


Files in This Item:
File Description SizeFormat 
art_FERREIRA_Inhibition_of_cPLA(2)_and_sPLA(2)_Activities_in_Primary_2012.PDF
  Restricted Access
publishedVersion (English)920.77 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.