Departamento de Clínica Médica - FM/MCM
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2021 DORIS definition of remission in SLE: final recommendations from an international task force
LUPUS SCIENCE & MEDICINE, v.8, n.1, article ID e000538, 8p, 2021
Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medica...
Measurement properties of selected patient-reported outcome measures for use in randomised controlled trials in patients with systemic lupus erythematosus: a systematic review
LUPUS SCIENCE & MEDICINE, v.7, n.1, article ID UNSP e000373, 14p, 2020
Objective The heterogeneous multisystem manifestations of SLE include fatigue, pain, depression, sleep disturbance and cognitive dysfunction, and underscore the importance of a multidimensional approach when assessing health-related quality of life. The US Food and Drug Administration has emphasi...
Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VII. Present and future of technologies for production of CAR cell therapies
HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, suppl.2, p.S46-S53, 2021
Chimeric Antigen Receptor T (CAR-T) cells are certainly an important therapy for patients with relapsed and/or refractory hematologic malignancies. Currently, there are five CAR-T cell products approved by the FDA but several research groups and/or biopharmaceutical companies are encouraged to de...
Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia
HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, suppl.2, p.S13-S21, 2021
Chimeric antigen receptor T (CAR-T) cell therapy is a novel therapeutic modality for acute lymphoblastic leukemia (ALL) with robust outcomes in patients with refractory or relapsed disease. At the same time, CAR-T cell therapy is associated with unique and potentially fatal toxicities, such as cy...
Applicability of the GLIM criteria for the diagnosis of malnutrition in older adults in the emergency ward: A pilot validation study
CLINICAL NUTRITION, v.40, n.11, p.5447-5456, 2021
Background & aims: Acutely ill older adults are at higher risk of malnutrition. This study aimed to explore the applicability and accuracy of the GLIM criteria to diagnose malnutrition in acutely ill older adults in the emergency ward (EW). Methods: We performed a retrospective secondary analysis...
Drug-Induced Anaphylaxis in Children
CURRENT TREATMENT OPTIONS IN ALLERGY, v.6, n.3, p.280-288, 2019
Purpose of reviewTo describe and analyze epidemiology, major triggers, diagnosis, and management of drug-induced anaphylaxis in pediatric population.Recent findingsDespite the fact that foods are the most common elicitors of anaphylaxis during childhood, frequency of those reactions during adoles...
The power of knowledge about dementia in Latin America across health professionals working on aging
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, v.12, n.1, article ID e12117, 12p, 2020
Introduction: Expert knowledge is critical to fight dementia in inequitable regions like Latin American and Caribbean countries (LACs). However, the opinions of aging experts on public policies' accessibility and transmission, stigma, diagnostic manuals, data-sharing platforms, and use of behavio...
The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension- Study design and challenges during the COVID-19 pandemic
CLINICS, v.76, article ID e2926, 8p, 2021
OBJECTIVES: To describe the MORPHEOS (Morbidity in patients with uncontrolled HTN and OSA) trial, and describe the challenges imposed by the COVID-19 pandemic. METHODS: MORPHEOS is a multicenter (n=6) randomized controlled trial designed to evaluate the blood pressure (BP) lowering effects of tre...
Cohort profile update: the main and new findings from the SaMi-Trop Chagas cohort
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.63, article ID e75, 11p, 2021
The SaMi-Trop project is a cohort study conducted in 21 municipalities of endemic areas of Chagas disease, including 1,959 patients with chronic Chagas cardiomyopathy. In this article we updated the results of the project, adding information from the second cohort visit. Trypanosoma cruzi-seropos...
CURRENT TREATMENT OPTIONS IN ALLERGY, v.7, n.3, p.370-380, 2020
Purpose of reviewQuinolones are the second most common antibiotic class that may induce IgE and non-IgE-mediated immediate hypersensitivity reactions. The prevalence of true quinolone allergy still remains unknown, but its incidence has increased in recent years, probably due to the extensive uti...