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Title: Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A(2)
Citation: CURRENT TOPICS IN MEDICINAL CHEMISTRY, v.12, n.21, p.2314-2323, 2012
Abstract: Physiological enzymatic cleavage of membrane phospholipids by phospholipase A(2) (PLA(2)) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA(2) (iPLA(2)) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA(2) activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/27

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