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Title: Clinical implication of 14-3-3 epsilon expression in gastric cancer
Authors: LEAL, Mariana FerreiraCALCAGNO, Danielle QueirozDEMACHKI, SamiaASSUMPCAO, Paulo PimentelCHAMMAS, RogerBURBANO, Rommel RodriguezSMITH, Marilia de Arruda Cardoso
Citation: WORLD JOURNAL OF GASTROENTEROLOGY, v.18, n.13, p.1531-1537, 2012
Abstract: AIM: To evaluate for the first time the protein and mRNA expression of 14-3-3 epsilon in gastric carcinogenesis. METHODS: 14-3-3 epsilon protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples. RESULTS: Authors observed a significant reduction of 14-3-3 epsilon protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue, Reduced levels of 14-3-3 epsilon were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3 epsilon may have a role in gastric carcinogenesis process. CONCLUSION: Our results reveal that the reduced 14-3-3 epsilon expression in GC and investigation of 14-3-3 epsilon interaction partners may help to elucidate the carcinogenesis process.
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Artigos e Materiais de Revistas Científicas - FM/MDR
Departamento de Radiologia - FM/MDR

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

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