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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBASSI, Marco Antonio-
dc.contributor.authorARIAS, Victor-
dc.contributor.authorD'AMICO FILHO, Nicolau-
dc.contributor.authorGUEUVOGHLANIAN-SILVA, Barbara Yasmin-
dc.contributor.authorABRAO, Mauricio Simoes-
dc.contributor.authorPODGAEC, Sergio-
dc.identifier.citationREPRODUCTIVE SCIENCES, v.22, n.9, Special Issue, p.1122-1128, 2015-
dc.description.abstractObjectives: The aim of this study was to analyze cell kinetics through expression and apoptosis of topoisomerase 2- (TOP2A), p53, and c-erb2 in rectosigmoid endometriotic lesions and in healthy endometrial tissue and to establish correlations between such findings and clinical data in patients with rectosigmoid endometriosis. Methods: Sixty patients with rectosigmoid endometriosis and 20 control women without endometriosis were included. Immunohistochemical assays were used to measure expression of TOP2A, p53, and c-erB-2. Apoptosis was quantified by directly counting the apoptotic bodies. Findings: The number of lesions was positively correlated with expression of TOP2A in the lesion. There was also significant correlation between the lesions' size and number and cell turnover index. Apoptosis index (AI) was the same for endometriosis lesions and eutopic endometrium. Expression of TOP2A was significantly lower in the endometriosis group compared to the controls. Conclusions: Changes in cell proliferation but not in the AI in rectosigmoid endometriosis are indicative of an imbalance in cell kinetics that may lead to the development of the disease.-
dc.relation.ispartofReproductive Sciences-
dc.subjectbowel endometriosis-
dc.subjectcell proliferation-
dc.subjectdeep infiltrating endometriosis-
dc.subjecttopoisomerase 2-alpha-
dc.subject.otherp53 expression-
dc.titleDeep Invasive Endometriosis Lesions of the Rectosigmoid May Be Related to Alterations in Cell Kinetics-
dc.rights.holderCopyright SAGE PUBLICATIONS INC-
dc.subject.wosObstetrics & Gynecology-
dc.subject.wosReproductive Biology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Marco Antonio:Univ Sao Paulo, Fac Med, Dept Obstet & Gynecol, Sao Paulo, Brazil-, Victor:Perola Byington Hosp, Dept Pathol, Sao Paulo, Brazil-'AMICO FILHO, Nicolau:Samaritano Hosp, Dept Obstet & Gynecol, Sao Paulo, Brazil-, Barbara Yasmin:Albert Einstein Hosp, Jewish Teaching & Res Inst, Sao Paulo, Brazil-
hcfmusp.description.issueSpecial Issue-
hcfmusp.publisher.cityTHOUSAND OAKS-
hcfmusp.relation.referenceAbrao MS, 2009, J ULTRAS MED, V28, P409-
hcfmusp.relation.referenceAbrao MS, 2009, J ULTRAS MED, V28, P408-
hcfmusp.relation.referenceBricou A, 2008, EUR J OBSTET GYN R B, V138, P127, DOI 10.1016/j.ejogrb.2008.01.014-
hcfmusp.relation.referenceCarvalho L, 2011, J MINIM INVAS GYN, V18, P419, DOI 10.1016/j.jmig.2011.03.009-
hcfmusp.relation.referenceCoronado Martín Pluvio J, 2007, Med Clin (Barc), V128, P1, DOI 10.1157/13096935-
hcfmusp.relation.referenceDarai E, 2005, AM J OBSTET GYNECOL, V192, P394, DOI 10.1016/j.ajog.2004.08.033-
hcfmusp.relation.referencede la Cuesta RS, 2004, EUR J OBSTET GYN R B, V113, P87, DOI 10.1016/S0301-2115(03)00367-1-
hcfmusp.relation.referenceDepalo R, 2009, REPROD BIOMED ONLINE, V19, P808-
hcfmusp.relation.referenceDmowski WP, 2001, HUM REPROD, V16, P1802, DOI 10.1093/humrep/16.9.1802-
hcfmusp.relation.referenceDufournet C, 2006, J REPROD IMMUNOL, V70, P151, DOI 10.1016/j.jri.2005.11.003-
hcfmusp.relation.referenceDupas C, 2008, ANN ENDOCRINOL-PARIS, V69, pS53, DOI 10.1016/S0003-4266(08)73969-6-
hcfmusp.relation.referenceFigueira PGM, 2011, ANN NY ACAD SCI, V1221, P10, DOI 10.1111/j.1749-6632.2011.05969.x-
hcfmusp.relation.referenceGAVRIELI Y, 1992, J CELL BIOL, V119, P493, DOI 10.1083/jcb.119.3.493-
hcfmusp.relation.referenceGoncalves MOD, 2010, HUM REPROD, V25, P665, DOI 10.1093/humrep/dep433-
hcfmusp.relation.referenceGonzalez-Ramos R, 2008, GYNECOL OBSTET INVES, V65, P174, DOI 10.1159/000111148-
hcfmusp.relation.referenceGupta S, 2008, FERTIL STERIL, V90, P247, DOI 10.1016/j.fertnstert.2008.02.093-
hcfmusp.relation.referenceHarada T, 2004, HUM REPROD UPDATE, V10, P29, DOI 10.1093/humupd/dmh007-
hcfmusp.relation.referenceHassa H, 2009, ARCH GYNECOL OBSTET, V280, P195, DOI 10.1007/s00404-008-0895-x-
hcfmusp.relation.referenceIlad Romina S, 2004, Reprod Biol Endocrinol, V2, P69, DOI 10.1186/1477-7827-2-69-
hcfmusp.relation.referenceInterthal H, 2011, BIOCHEM J, V436, P559, DOI 10.1042/BJ20101841-
hcfmusp.relation.referenceJanzen DM, 2013, STEM CELLS, V31, P808, DOI 10.1002/stem.1337-
hcfmusp.relation.referenceJiang XX, 1998, CANCER RES, V58, P1707-
hcfmusp.relation.referenceJiang XX, 1996, CANCER RES, V56, P3534-
hcfmusp.relation.referenceJones RK, 1998, BIOL REPROD, V58, P995, DOI 10.1095/biolreprod58.4.995-
hcfmusp.relation.referenceNakayama K, 2001, INT J GYNECOL PATHOL, V20, P227, DOI 10.1097/00004347-200107000-00004-
hcfmusp.relation.referenceNasu K, 2011, J OBSTET GYNAECOL RE, V37, P683, DOI 10.1111/j.1447-0756.2011.01663.x-
hcfmusp.relation.referenceNisolle M, 1997, FERTIL STERIL, V68, P585, DOI 10.1016/S0015-0282(97)00191-X-
hcfmusp.relation.referencePodgaec S, 2007, HUM REPROD, V22, P1373, DOI 10.1093/humrep/del516-
hcfmusp.relation.referencePupo-Nogueira A, 2007, INT J GYNECOL OBSTET, V99, P33, DOI 10.1016/j.ijgo.2007.04.033-
hcfmusp.relation.referenceReis FM, 2013, HUM REPROD UPDATE, V19, P406, DOI 10.1093/humupd/dmt010-
hcfmusp.relation.referenceRosa-e-Silva JC, 2010, FERTIL STERIL, V93, P1637, DOI 10.1016/j.fertnstert.2009.01.126-
hcfmusp.relation.referenceRosa-e-Silva JC, 2008, CLIMACTERIC, V11, P525, DOI 10.1080/13697130802490256-
hcfmusp.relation.referenceSampson JA, 1927, AM J PATHOL, V3, P93-
hcfmusp.relation.referenceSchneider J, 1998, ONCOL REP, V5, P49-
hcfmusp.relation.referenceSHARPETIMMS KL, 1995, J CLIN ENDOCR METAB, V80, P3784, DOI 10.1210/jc.80.12.3784-
hcfmusp.relation.referenceSong GG, 2014, IMMUNOL INVEST, V43, P595, DOI 10.3109/08820139.2013.833623-
hcfmusp.relation.referenceUzan C, 2009, VIRCHOWS ARCH, V454, P525, DOI 10.1007/s00428-009-0755-5-
hcfmusp.relation.referenceVigano P, 2006, HUM REPROD UPDATE, V12, P77, DOI 10.1093/humupd/dmi037-
hcfmusp.relation.referenceWatanabe H, 1997, AM J OBSTET GYNECOL, V176, P360, DOI 10.1016/S0002-9378(97)70499-X-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

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