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https://observatorio.fm.usp.br/handle/OPI/1194| Title: | IN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE) |
| Authors: | SARTORELLI, Patricia; SANTANA, Jefferson S.; GUADAGNIN, Rafael C.; LAGO, Joao Henrique G.; PINTO, Erika G.; TEMPONE, Andre G.; STEFANI, Helio A.; SOARES, Marisi G.; SILVA, Adalberto M. da |
| Citation: | QUIMICA NOVA, v.35, n.4, p.743-747, 2012 |
| Abstract: | Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-alpha-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 mu g/mL) when compared to benznidazole (IC50 43.14 mu g/mL). Otherwise, (-)-alpha-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 mu g/mL) while (-)-pinane showed an IC50 of 56.50 mu g/mL. The obtained results indicated that the epoxydation of a-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - IMT |
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| art_PINTO_IN_VITRO_TRYPANOCIDAL_EVALUATION_OF_PINANE_DERIVATIVES_FROM_2012.PDF | publishedVersion (English) | 307.41 kB | Adobe PDF |  View/Open |
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