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Título: IN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE)
Autor: SARTORELLI, PatriciaSANTANA, Jefferson S.GUADAGNIN, Rafael C.LAGO, Joao Henrique G.PINTO, Erika G.TEMPONE, Andre G.STEFANI, Helio A.SOARES, Marisi G.SILVA, Adalberto M. da
Citación: QUIMICA NOVA, v.35, n.4, p.743-747, 2012
Resumen: Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-alpha-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 mu g/mL) when compared to benznidazole (IC50 43.14 mu g/mL). Otherwise, (-)-alpha-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 mu g/mL) while (-)-pinane showed an IC50 of 56.50 mu g/mL. The obtained results indicated that the epoxydation of a-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
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Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT


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