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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSARTORELLI, Patricia-
dc.contributor.authorSANTANA, Jefferson S.-
dc.contributor.authorGUADAGNIN, Rafael C.-
dc.contributor.authorLAGO, Joao Henrique G.-
dc.contributor.authorPINTO, Erika G.-
dc.contributor.authorTEMPONE, Andre G.-
dc.contributor.authorSTEFANI, Helio A.-
dc.contributor.authorSOARES, Marisi G.-
dc.contributor.authorSILVA, Adalberto M. da-
dc.date.accessioned2013-07-30T15:32:33Z-
dc.date.available2013-07-30T15:32:33Z-
dc.date.issued2012-
dc.identifier.citationQUIMICA NOVA, v.35, n.4, p.743-747, 2012-
dc.identifier.issn0100-4042-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1194-
dc.description.abstractEssential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-alpha-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 mu g/mL) when compared to benznidazole (IC50 43.14 mu g/mL). Otherwise, (-)-alpha-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 mu g/mL) while (-)-pinane showed an IC50 of 56.50 mu g/mL. The obtained results indicated that the epoxydation of a-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.-
dc.description.sponsorshipFAPESP-
dc.description.sponsorshipCNPq-
dc.language.isoeng-
dc.publisherSOC BRASILEIRA QUIMICA-
dc.relation.ispartofQuimica Nova-
dc.rightsopenAccess-
dc.subjectSchinus terebinthifolius Raddi-
dc.subjectAnacardiaceae-
dc.subjecttrypanocidal activity-
dc.subject.otherchemical-composition-
dc.subject.otherleaves-
dc.subject.othermonoterpenes-
dc.subject.otherberries-
dc.titleIN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE)-
dc.typearticle-
dc.rights.holderCopyright SOC BRASILEIRA QUIMICA-
dc.identifier.doi10.1590/S0100-40422012000400017-
dc.subject.wosChemistry, Multidisciplinary-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalSARTORELLI, Patricia:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972279 Diadema, SP, Brazil-
hcfmusp.author.externalSANTANA, Jefferson S.:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972279 Diadema, SP, Brazil-
hcfmusp.author.externalGUADAGNIN, Rafael C.:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972279 Diadema, SP, Brazil-
hcfmusp.author.externalLAGO, Joao Henrique G.:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972279 Diadema, SP, Brazil-
hcfmusp.author.externalTEMPONE, Andre G.:Adolfo Lutz Inst, Dept Parasitol, BR-01246000 Sao Paulo, Brazil-
hcfmusp.author.externalSTEFANI, Helio A.:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508000 Sao Paulo, Brazil-
hcfmusp.author.externalSOARES, Marisi G.:Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG, Brazil-
hcfmusp.author.externalSILVA, Adalberto M. da:Univ Fed Vicosa, Dept Quim, BR-36570000 Vicosa, MG, Brazil-
hcfmusp.description.beginpage743-
hcfmusp.description.endpage747-
hcfmusp.description.issue4-
hcfmusp.description.volume35-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84862892188-
hcfmusp.origem.idWOS:000304226400017-
hcfmusp.publisher.citySAO PAULO-
hcfmusp.publisher.countryBRAZIL-
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dc.description.indexPubMed-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.citation.scopus17-
hcfmusp.scopus.lastupdate2022-05-06-
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