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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCAVALCANTE, Lourianne N.-
dc.contributor.authorABE-SANDES, Kiyoko-
dc.contributor.authorANGELO, Ana Luisa D.-
dc.contributor.authorMACHADO, Taisa M. B.-
dc.contributor.authorLEMAIRE, Denise C.-
dc.contributor.authorMENDES, Carlos M. C.-
dc.contributor.authorPINHO, Joao R.-
dc.contributor.authorMALTA, Fernanda-
dc.contributor.authorLYRA, Luiz G. C.-
dc.contributor.authorLYRA, Andre C.-
dc.identifier.citationLIVER INTERNATIONAL, v.32, n.3, p.476-486, 2012-
dc.description.abstractBackground: IL28B polymorphisms are predictors of therapy response in hepatitis C virus (HCV) patients. We do not know whether they are markers of treatment response in admixed populations or not. Aims: To determine whether IL28B polymorphisms are predictors of therapy response in patients with HCV from an admixed population and are influenced by genetic ancestry. Methods: rs12979860 and rs8099917 were genotyped in 222 HCV patients treated with pegylated interferon and ribavirin. Ancestry was determined using genetic markers. Results: IL28B rs12979860 C/C was associated with sustained virological response (SVR), whereas C/T and T/T were associated with failure to therapy (P = 1.12 x 10(-5)). IL28B rs8099917 T/T was associated with SVR, and G/G and G/T were associated with nonresponse/ relapse (NR/R) (P = 8.00 x 10(-3)). Among HCV genotype 1 patients with C/C genotype, genomic ancestry did not interfere with therapy response. Among patients with rs12979860 T/T genotype, African genetic contribution was greater in the NR/R group (P = 1.51 x 10(-3)), whereas Amerindian and European genetic ancestry contribution were higher in the SVR group (P = 3.77 x 10(-3) and P = 2.16 x 10(-2) respectively). Among HCV type 1 patients with rs8099917 T/T, African genetic contribution was significantly greater in the NR/R group (P = 5.0 x 10(-3)); Amerindian and European ancestry genetic contribution were greater in the SVR group. Conclusion: IL28B rs12979860 and rs8099917 polymorphisms were predictors of therapy response in HCV genotypes 1, 2 and 3 subjects from an admixed population. Genomic ancestry did not interfere with response to therapy in patients with rs12979860 C/C, whereas it interfered in patients with C/T and T/T genotypes. Among HCV genotype 1 rs8099917 T/T patients, genomic ancestry interfered with response to therapy.-
dc.description.sponsorshipFapesb [SUS0001/2011]-
dc.description.sponsorshipFapesp [10/10549-1]-
dc.relation.ispartofLiver International-
dc.subjectantiviral therapy-
dc.subjectgenetic ancestry-
dc.subjecthepatitis C-
dc.subjectsingle nucleotide-
dc.subject.othervirus genotype 2-
dc.subject.otherpeginterferon alpha-2b-
dc.subject.otherspontaneous clearance-
dc.subject.othervirological response-
dc.subject.otherplus ribavirin-
dc.titleIL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population-
dc.rights.holderCopyright WILEY-BLACKWELL-
dc.subject.wosGastroenterology & Hepatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Lourianne N.:Fed Univ Bahia UFBA, Dept Med, Salvador, BA, Brazil; Hosp Sao Rafael Monte Tabor, Gastrohepatol Serv, Salvador, BA, Brazil-, Kiyoko:Fed Univ Bahia UFBA, Lab Immunol Hlth Sci Inst ICS, Salvador, BA, Brazil; State Univ Bahia UNEB, Dept Life Sci, Salvador, BA, Brazil-, Ana Luisa D.:Fed Univ Bahia UFBA, Lab Immunol Hlth Sci Inst ICS, Salvador, BA, Brazil-, Taisa M. B.:Fed Univ Bahia UFBA, Lab Immunol Hlth Sci Inst ICS, Salvador, BA, Brazil-, Denise C.:Fed Univ Bahia UFBA, Lab Immunol Hlth Sci Inst ICS, Salvador, BA, Brazil; Bahiana Sch Med & Publ Hlth EBMSP, Salvador, BA, Brazil-, Carlos M. C.:Univ Fed Bahia, Fima Lifshitz Res Ctr, BR-41170290 Salvador, BA, Brazil-, Luiz G. C.:Fed Univ Bahia UFBA, Dept Med, Salvador, BA, Brazil; Hosp Sao Rafael Monte Tabor, Gastrohepatol Serv, Salvador, BA, Brazil-, Andre C.:Fed Univ Bahia UFBA, Dept Med, Salvador, BA, Brazil; Hosp Sao Rafael Monte Tabor, Gastrohepatol Serv, Salvador, BA, Brazil-
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

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