https://observatorio.fm.usp.br/handle/OPI/12285
Title: | Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats |
Authors: | CAMARGO, Cristina Pires; JACOMO, Alfredo Luiz; BATTLEHNER, Claudia Naves; LEMOS, Miriam; SALDIVA, Paulo Hilario; MARTINS, Milton Arruda; MUNHOZ, Alexandre Mendonca; GEMPERLI, Rolf |
Citation: | ACTA CIRURGICA BRASILEIRA, v.30, n.9, p.639-645, 2015 |
Abstract: | PURPOSE: To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in healthy, tobacco-exposed and diabetic rats. METHODS: Ninety male Wistar rats (250-300g) were randomly divided into six groups: control+saline (C1), control+BoNTA (C2), tobacco-exposed+saline (T1), tobacco-exposed+BoNTA (T2) diabetes+saline (D1) and diabetes+BoNTA (D2). A dorsal cutaneous flap (3x10cm) was performed. Survival area and total area of the flaps were measured. Lumen diameter, external arterial diameter and lumen/wall thickness ratio were recorded. RESULTS: Survival area increased in control group with BoNTA injection compared with control animals injected with saline (C2 x C1; 0.9 +/- 0.1 vs 0.67 +/- 0.15, p=0.001). A similar result was found in diabetes group injected with BontA (D2 x D1; 0.97 +/- 0.2 vs 0.61 +/- 0.24, p=0.018). No difference was observed in skin flap viability in tobacco-exposed groups (T2 x T1; 0.74 +/- 0.24 vs 0.64 +/- 0.21, p=0.871). Lumen diameter (p=0.004), external arterial diameter (p=0.0046,) and lumen/wall thickness ratio (p=0.003) were increased in diabetes+BoNTA-treated animals. This effect was not observed in control or in tobacco-exposed groups. CONCLUSIONS: Botulinum toxin A increased skin flap viability in control and diabetic rats on the seventh post-operative day. Increased lumen diameter, external arterial diameter, and lumen/wall thickness ratio were observed in the diabetes+BoNTA group. BoNTA had no effect in the tobacco-exposed group on the seventh postoperative day. |
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File | Description | Size | Format | |
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art_CAMARGO_Botulinum_toxin_type_A_on_cutaneous_flap_viability_2015.PDF | publishedVersion (English) | 1.3 MB | Adobe PDF | View/Open |
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