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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBATISTUZZO, Marcelo Camargo-
dc.contributor.authorBALARDIN, Joana Bisol-
dc.contributor.authorMARTIN, Maria da Graca Morais-
dc.contributor.authorHOEXTER, Marcelo Queiroz-
dc.contributor.authorBERNARDES, Elisa Teixeira-
dc.contributor.authorBORCATO, Sonia-
dc.contributor.authorSOUZA, Marina de Marco e-
dc.contributor.authorQUERIDO, Cicero Nardini-
dc.contributor.authorMORAIS, Rosa Magaly-
dc.contributor.authorALVARENGA, Pedro Gomes de-
dc.contributor.authorLOPES, Antonio Carlos-
dc.contributor.authorSHAVITT, Roseli Gedanke-
dc.contributor.authorSAVAGE, Cary R.-
dc.contributor.authorAMARO JR., Edson-
dc.contributor.authorMIGUEL, Euripedes C.-
dc.contributor.authorPOLANCZYK, Guilherme V.-
dc.contributor.authorMIOTTO, Eliane C.-
dc.identifier.citationJOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v.54, n.10, p.849-858, 2015-
dc.description.abstractObjective: Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic, clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)-encoding paradigm. Method: A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results: The semantic clustering strategy score (SCS) predicted VEM performance in HC (p <.001, R-2 = 0.635), but not in patients (p =.099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p <.001). Within-group analysis revealed a negative correlation between Yale-Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC (p = .001, r = 0.635), but not in patients with OCD (p = .936, r = 0.017). Conclusion: Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Foundation for the Support of Research in State of Sao Paulo) [2009/09949-8]-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, National Council for Scientific and Technological Development) [573974/2008-0]-
dc.description.sponsorshipNational Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil-
dc.relation.ispartofJournal of the American Academy of Child and Adolescent Psychiatry-
dc.subjectobsessive-compulsive disorder-
dc.subjectfunctional magnetic resonance imaging-
dc.subjectverbal episodic memory-
dc.subjectsemantic clustering-
dc.subject.othertraumatic brain-injury-
dc.subject.otherneuropsychological performance-
dc.subject.otherfunctional connectivity-
dc.subject.otherdirected application-
dc.subject.otherlearning strategies-
dc.subject.otherexecutive functions-
dc.subject.othercognitive control-
dc.subject.otherbipolar disorder-
dc.titleReduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.subject.wosPsychology, Developmental-
dc.type.categoryoriginal article-
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Departamento de Psiquiatria - FM/MPS

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Instituto de Psiquiatria - HC/IPq

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LIM/21 - Laboratório de Neuroimagem em Psiquiatria

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