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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBATISTUZZO, Marcelo Camargo-
dc.contributor.authorBALARDIN, Joana Bisol-
dc.contributor.authorMARTIN, Maria da Graca Morais-
dc.contributor.authorHOEXTER, Marcelo Queiroz-
dc.contributor.authorBERNARDES, Elisa Teixeira-
dc.contributor.authorBORCATO, Sonia-
dc.contributor.authorSOUZA, Marina de Marco e-
dc.contributor.authorQUERIDO, Cicero Nardini-
dc.contributor.authorMORAIS, Rosa Magaly-
dc.contributor.authorALVARENGA, Pedro Gomes de-
dc.contributor.authorLOPES, Antonio Carlos-
dc.contributor.authorSHAVITT, Roseli Gedanke-
dc.contributor.authorSAVAGE, Cary R.-
dc.contributor.authorAMARO JR., Edson-
dc.contributor.authorMIGUEL, Euripedes C.-
dc.contributor.authorPOLANCZYK, Guilherme V.-
dc.contributor.authorMIOTTO, Eliane C.-
dc.date.accessioned2015-12-10T16:42:31Z-
dc.date.available2015-12-10T16:42:31Z-
dc.date.issued2015-
dc.identifier.citationJOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v.54, n.10, p.849-858, 2015-
dc.identifier.issn0890-8567-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12363-
dc.description.abstractObjective: Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic, clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)-encoding paradigm. Method: A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results: The semantic clustering strategy score (SCS) predicted VEM performance in HC (p <.001, R-2 = 0.635), but not in patients (p =.099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p <.001). Within-group analysis revealed a negative correlation between Yale-Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC (p = .001, r = 0.635), but not in patients with OCD (p = .936, r = 0.017). Conclusion: Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Foundation for the Support of Research in State of Sao Paulo) [2009/09949-8]-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, National Council for Scientific and Technological Development) [573974/2008-0]-
dc.description.sponsorshipNational Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE BV-
dc.relation.ispartofJournal of the American Academy of Child and Adolescent Psychiatry-
dc.rightsrestrictedAccess-
dc.subjectobsessive-compulsive disorder-
dc.subjectfunctional magnetic resonance imaging-
dc.subjectverbal episodic memory-
dc.subjectsemantic clustering-
dc.subject.othertraumatic brain-injury-
dc.subject.otherneuropsychological performance-
dc.subject.otherfree-recall-
dc.subject.otherfunctional connectivity-
dc.subject.otherdirected application-
dc.subject.otherlearning strategies-
dc.subject.otherexecutive functions-
dc.subject.othercognitive control-
dc.subject.otherbipolar disorder-
dc.subject.othercortex-
dc.titleReduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.identifier.doi10.1016/j.jaac.2015.06.020-
dc.identifier.pmid26407495-
dc.subject.wosPsychology, Developmental-
dc.subject.wosPediatrics-
dc.subject.wosPsychiatry-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.description.beginpage849-
hcfmusp.description.endpage858-
hcfmusp.description.issue10-
hcfmusp.description.volume54-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84942294024-
hcfmusp.origem.idWOS:000362056800013-
hcfmusp.publisher.cityAMSTERDAM-
hcfmusp.publisher.countryNETHERLANDS-
hcfmusp.relation.referenceAmerican Academy of Child and Adolescent Psychiatry, 2012, J AM ACAD CHILD ADOL, V51, P98, DOI 10.1016/J.JAAC.2011.09.019-
hcfmusp.relation.referenceAndrade LH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031879-
hcfmusp.relation.referenceBari A, 2013, PROG NEUROBIOL, V108, P44, DOI 10.1016/j.pneurobio.2013.06.005-
hcfmusp.relation.referenceBritton JC, 2010, J AM ACAD CHILD PSY, V49, P944, DOI 10.1016/j.jaac.2010.05.006-
hcfmusp.relation.referenceEvans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925-
hcfmusp.relation.referenceKonishi M, 2011, NEUROPSYCH DIS TREAT, V7, P365, DOI 10.2147/NDT.S21047-
hcfmusp.relation.referenceHuyser C, 2010, J AM ACAD CHILD PSY, V49, P1238, DOI 10.1016/j.jaac.2010.08.007-
hcfmusp.relation.referenceMiotto EC, 2013, CLIN NEUROL NEUROSUR, V115, P309, DOI 10.1016/j.clineuro.2012.05.024-
hcfmusp.relation.referenceFitzgerald KD, 2013, J AM ACAD CHILD PSY, V52, P1183, DOI 10.1016/j.jaac.2013.09.002-
hcfmusp.relation.referenceKashyap H, 2013, COMPR PSYCHIAT, V54, P533, DOI 10.1016/j.comppsych.2012.12.003-
hcfmusp.relation.referenceAndres S, 2007, BIOL PSYCHIAT, V61, P946, DOI 10.1016/j.biopsych.2006.07.027-
hcfmusp.relation.referenceChudasama Y, 2006, BIOL PSYCHOL, V73, P19, DOI 10.1016/j.biopsycho.2006.01.005-
hcfmusp.relation.referenceSavage CR, 1999, BIOL PSYCHIAT, V45, P905, DOI 10.1016/S0006-3223(98)00278-9-
hcfmusp.relation.referenceJang JH, 2010, NEUROSCI LETT, V474, P158, DOI 10.1016/j.neulet.2010.03.031-
hcfmusp.relation.referenceBannon S, 2006, AUST NZ J PSYCHIAT, V40, P1031, DOI 10.1080/j.1440-1614.2006.01928.x-
hcfmusp.relation.referencePOZNANSKI E, 1985, AM J PSYCHIAT, V142, P1168-
hcfmusp.relation.referenceLong NM, 2010, J NEUROSCI, V30, P10967, DOI 10.1523/JNEUROSCI.2611-10.2010-
hcfmusp.relation.referenceHarrison BJ, 2009, ARCH GEN PSYCHIAT, V66, P1189, DOI 10.1001/archgenpsychiatry.2009.152-
hcfmusp.relation.referenceDeckersbach T, 2005, BIPOLAR DISORD, V7, P166, DOI 10.1111/j.1399-5618.2004.00168.x-
hcfmusp.relation.referenceSaxena S, 1999, NEUROPSYCHOPHARMACOL, V21, P683, DOI 10.1016/S0893-133X(99)00082-2-
hcfmusp.relation.referenceManes F, 1999, J NEUROL NEUROSUR PS, V67, P532, DOI 10.1136/jnnp.67.4.532-
hcfmusp.relation.referenceOlley A, 2007, J AFFECT DISORDERS, V104, P15, DOI 10.1016/j.jad.2007.02.023-
hcfmusp.relation.referenceAbramovitch A, 2013, CLIN PSYCHOL REV, V33, P1163, DOI 10.1016/j.cpr.2013.09.004-
hcfmusp.relation.referencePostle N, 2008, NEUROIMAGE, V43, P634, DOI 10.1016/j.neuroimage.2008.08.006-
hcfmusp.relation.referenceAbramovitch A, 2015, PSYCHIAT RES, V228, P112, DOI 10.1016/j.psychres.2015.04.025-
hcfmusp.relation.referenceAndres S, 2008, J PSYCHIATR RES, V42, P507, DOI 10.1016/j.jpsychires.2007.04.004-
hcfmusp.relation.referenceStrangman GE, 2009, NEUROREHAB NEURAL RE, V23, P226, DOI 10.1177/1545968308324225-
hcfmusp.relation.referenceGeller D, 2000, DEPRESS ANXIETY, V11, P163, DOI 10.1002/1520-6394(2000)11:4<163::AID-DA3>3.0.CO;2-3-
hcfmusp.relation.referenceWoolrich MW, 2001, NEUROIMAGE, V14, P1370, DOI 10.1006/nimg.2001.0931-
hcfmusp.relation.referenceMenzies L, 2008, NEUROSCI BIOBEHAV R, V32, P525, DOI 10.1016/j.neubiorev.2007.09.005-
hcfmusp.relation.referenceFranklin ME, 2011, JAMA-J AM MED ASSOC, V306, P1224, DOI 10.1001/jama.2011.1344-
hcfmusp.relation.referencePrice CJ, 1999, HUM BRAIN MAPP, V8, P102, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<102::AID-HBM6>3.0.CO;2-J-
hcfmusp.relation.referenceStrangman GE, 2008, ARCH PHYS MED REHAB, V89, P974, DOI 10.1016/j.apmr.2008.02.011-
hcfmusp.relation.referenceKaufman J, 2000, J AM ACAD CHILD PSY, V39, P1208, DOI 10.1097/00004583-200010000-00002-
hcfmusp.relation.referenceSavage CR, 2000, AM J PSYCHIAT, V157, P1182, DOI 10.1176/appi.ajp.157.7.1182-
hcfmusp.relation.referenceWoo CW, 2014, NEUROIMAGE, V91, P412, DOI 10.1016/j.neuroimage.2013.12.058-
hcfmusp.relation.referenceSavage CR, 1996, J NEUROPSYCH CLIN N, V8, P99-
hcfmusp.relation.referenceHuyser C, 2011, J CHILD PSYCHOL PSYC, V52, P1251, DOI 10.1111/j.1469-7610.2011.02439.x-
hcfmusp.relation.referenceOLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4-
hcfmusp.relation.referenceDeckersbach T, 2000, PSYCHOTHER PSYCHOSOM, V69, P101, DOI 10.1159/000012373-
hcfmusp.relation.referenceBuhlmann U, 2006, PSYCHIAT RES, V144, P109, DOI 10.1016/j.psychres.2006.10.012-
hcfmusp.relation.referenceGeller DA, 2006, PSYCHIAT CLIN N AM, V29, P353, DOI 10.1016/j.psc.2006.02.012-
hcfmusp.relation.referenceKessler RC, 2012, ARCH GEN PSYCHIAT, V69, P372, DOI 10.1001/archgenpsychiatry.2011.160-
hcfmusp.relation.referenceBirmaher B, 1999, J AM ACAD CHILD PSY, V38, P1230, DOI 10.1097/00004583-199910000-00011-
hcfmusp.relation.referenceMiotto EC, 2006, HUM BRAIN MAPP, V27, P288, DOI 10.1002/hbm.20184-
hcfmusp.relation.referenceChang SW, 2007, J CLIN EXP NEUROPSYC, V29, P724, DOI 10.1080/13825580600966383-
hcfmusp.relation.referenceBrennan E, 2015, PSYCHIAT RES, V227, P135, DOI 10.1016/j.psychres.2015.03.032-
hcfmusp.relation.referenceMiller EK, 2001, ANNU REV NEUROSCI, V24, P167, DOI 10.1146/annurev.neuro.24.1.167-
hcfmusp.relation.referenceRAUCH SL, 1994, ARCH GEN PSYCHIAT, V51, P62-
hcfmusp.relation.referenceShin NY, 2014, PSYCHOL MED, V44, P1121, DOI 10.1017/S0033291713001803-
hcfmusp.relation.referenceFireman B, 2001, AM J PSYCHIAT, V158, P1904, DOI 10.1176/appi.ajp.158.11.1904-
hcfmusp.relation.referenceOrnstein TJ, 2010, DEPRESS ANXIETY, V27, P372, DOI 10.1002/da.20638-
hcfmusp.relation.referenceBeucke JC, 2013, JAMA PSYCHIAT, V70, P619, DOI 10.1001/jamapsychiatry.2013.173-
hcfmusp.relation.referenceRuscio AM, 2010, MOL PSYCHIATR, V15, P53, DOI 10.1038/mp.2008.94-
hcfmusp.relation.referenceTukel R, 2012, COMPR PSYCHIAT, V53, P167, DOI 10.1016/j.comppsych.2011.03.007-
hcfmusp.relation.referencede Wit SJ, 2012, AM J PSYCHIAT, V169, P1100, DOI 10.1176/appi.ajp.2012.12010073-
hcfmusp.relation.referenceJenkinson M, 2001, MED IMAGE ANAL, V5, P143, DOI 10.1016/S1361-8415(01)00036-6-
hcfmusp.relation.referenceJenkinson M, 2012, NEUROIMAGE, V62, P782, DOI 10.1016/j.neuroimage.2011.09.015-
hcfmusp.relation.referenceFletcher PC, 1998, BRAIN, V121, P1249, DOI 10.1093/brain/121.7.1249-
hcfmusp.relation.referenceWoon FL, 2012, NEUROCASE, V18, P424, DOI 10.1080/13554794.2011.627342-
hcfmusp.relation.referenceKuelz AK, 2004, BIOL PSYCHOL, V65, P185, DOI 10.1016/j.biopsycho.2003.07.007-
hcfmusp.relation.referenceKoechlin E, 2003, SCIENCE, V302, P1181, DOI 10.1126/science.1088545-
hcfmusp.relation.referenceJenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132-
hcfmusp.relation.referenceStaresina BP, 2006, J NEUROSCI, V26, P9162, DOI 10.1523/JNEUROSCI.2877-06.2006-
hcfmusp.relation.referenceDeckersbach T, 2000, J CLIN EXP NEUROPSYC, V22, P640, DOI 10.1076/1380-3395(200010)22:5;1-9;FT640-
hcfmusp.relation.referenceSavage CR, 2001, BRAIN, V124, P219, DOI 10.1093/brain/124.1.219-
hcfmusp.relation.referenceSavage CR, 2000, NEUROPSYCHOLOGY, V14, P141, DOI 10.1037/0894-4105.14.1.141-
hcfmusp.relation.referenceRosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798-
hcfmusp.relation.referenceZitterl W, 2001, PSYCHOPATHOLOGY, V34, P113, DOI 10.1159/000049292-
hcfmusp.relation.referenceDeckersbach T, 2004, BIPOLAR DISORD, V6, P233, DOI 10.1111/j.1399-5618.2004.00118.x-
hcfmusp.relation.referenceShin MS, 2008, EUR PSYCHIAT, V23, P512, DOI 10.1016/j.eurpsy.2008.03.010-
hcfmusp.relation.referenceFletcher PC, 1998, BRAIN, V121, P1239, DOI 10.1093/brain/121.7.1239-
hcfmusp.relation.referenceRottschy C, 2012, NEUROIMAGE, V60, P830, DOI 10.1016/j.neuroimage.2011.11.050-
hcfmusp.relation.referenceChamberlain SR, 2008, SCIENCE, V321, P421, DOI 10.1126/science.1154433-
hcfmusp.relation.referenceDelis DC, 2010, CLIN NEUROPSYCHOL, V24, P70, DOI 10.1080/13854040903002232-
hcfmusp.relation.referenceLovstad M, 2012, BRAIN COGNITION, V80, P237, DOI 10.1016/j.bandc.2012.07.008-
hcfmusp.relation.referenceBEHAR D, 1984, AM J PSYCHIAT, V141, P363-
hcfmusp.relation.referencede Vries FE, 2014, BIOL PSYCHIAT, V76, P878, DOI 10.1016/j.biopsych.2013.11.021-
hcfmusp.relation.referenceChen SL, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-39-
hcfmusp.relation.referenceFuster JM, 2008, PREFRONTAL CORTEX, 4TH EDITION, P1-
hcfmusp.relation.referenceGOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006-
hcfmusp.relation.referenceGuillery-Girard B, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00126-
hcfmusp.relation.referenceIrlbacher K, 2014, NEUROSCI BIOBEHAV R, V46, P58, DOI 10.1016/j.neubiorev.2014.06.014-
hcfmusp.relation.referenceMiotto EC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105987-
hcfmusp.relation.referencePETERSEN AC, 1988, J YOUTH ADOLESCENCE, V17, P117, DOI 10.1007/BF01537962-
hcfmusp.relation.referenceStein LM, 1994, TDE TASTE DESEMPENHO-
hcfmusp.relation.referenceTULVING E, 1962, PSYCHOL REV, V69, P344, DOI 10.1037/h0043150-
hcfmusp.relation.referenceWechsler D., 1999, WECHSLER ABBREVIATED-
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