Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/13512
Title: Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations
Authors: SILVA, Leia Cristina RodriguesARAUJO, Adriana Ladeira deFERNANDES, Juliana RuizMATIAS, Manuella de Sousa ToledoSILVA, Paulo RobertoDUARTE, Alberto J. S.LEME, Luiz Eugenio GarcezBENARD, Gil
Citation: AGE, v.38, n.1, article ID 24, 16p, 2016
Abstract: Studies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4(+)/TCD8(+) naive compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA(+) CCR7(neg)) TCD4 (+) and TCD8(+) cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4(+) cells, while ITwas associated with higher proportion of effector memory TCD8(+) cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28(neg)) TCD8(+) cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8(+) cells, whereas with MT, a modest increase in telomere length was observed in both TCD8(+) and TCD4(+) cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT. Measurement of pro-inflammatory cytokines in serum and peripheral blood mononuclear cell (PBMC)' s supernatants did not show chronic low-grade inflammation in any of the groups. In conclusion, MT and IT lifestyles attenuated some of the effects of aging on the immune system.
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LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências


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