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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorTRIBL, Gotthard G.-
dc.contributor.authorTRINDADE, Mateus C.-
dc.contributor.authorBITTENCOURT, Thais-
dc.contributor.authorLORENZI-FILHO, Geraldo-
dc.contributor.authorALVES, Rosana Cardoso-
dc.contributor.authorANDRADE, Daniel Ciampi de-
dc.contributor.authorFONOFF, Erich T.-
dc.contributor.authorBOR-SENG-SHU, Edson-
dc.contributor.authorMACHADO, Alexandre A.-
dc.contributor.authorSCHENCK, Carlos H.-
dc.contributor.authorTEIXEIRA, Manoel J.-
dc.contributor.authorBARBOSA, Egberto R.-
dc.identifier.citationSLEEP MEDICINE, v.17, p.179-185, 2016-
dc.description.abstractObjective: Quantitative data are reported on rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of predominantly neurological Wilson's disease (WD). Methods: A total of 41 patients with WD and 41 healthy, age-and gender-matched controls were studied by conducting face-to-face interviews, neurological and clinical examinations, laboratory tests, and WD and RBD-specific scales. Video-polysomnography and quantification of REM sleep without atonia (RWA) were conducted in 35 patients and 41 controls. Results: Patients with WD showed significantly worse sleep quality, less sleep efficiency, increased wakefulness after sleep onset, and more arousals compared to healthy controls. Five patients with WD (four women) fulfilled the diagnostic criteria for RBD with significantly higher values in RWA, RBD Questionnaire Hong Kong, and RBD Screening Questionnaire compared to patients with WD without RBD. In three patients with WD, RBD had manifested before any other symptom that could be attributed to WD. Percentage of RWA was significantly lower in WD without RBD than in WD with RBD, but still significantly increased compared to controls. Conclusions: RBD can be comorbid with WD. RWA is commonly present in WD, both in the presence or absence of clinical RBD. A causal connection is possible, though retrospective determination of RBD onset and the low number of patients do not allow a definitive conclusion at this point. However, screening for WD in idiopathic RBD is available at low cost and is recommended. Early-stage copper chelation therapy provides a highly effective treatment to prevent further WD manifestations and might also control the comorbid RBD.-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2012/05403-3]-
dc.relation.ispartofSleep Medicine-
dc.subjectRapid eye movement sleep behavior disorder-
dc.subjectWilson's disease-
dc.subjectParkinsonian syndromes-
dc.subjectSleep disorders-
dc.subjectMovement disorders-
dc.subject.otherneurodegenerative disease-
dc.subject.otherquality index-
dc.subject.otherbrain mri-
dc.titleWilson's disease with and without rapid eye movement sleep behavior disorder compared to healthy matched controls-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.subject.wosClinical Neurology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Mateus C.:Univ Sao Paulo, Sch Med, Hosp Clin, Div Neurol & Neurosurg, Ave Dr Eneas Carvalho Aguiar,255,5 Andar, BR-05403900 Sao Paulo, Brazil-, Carlos H.:Hennepin Cty Med Ctr, Minnesota Reg Sleep Disorders Ctr, Dept Psychiat, 701 Pk Ave, Minneapolis, MN 55415 USA; Univ Minnesota, Sch Med, 701 Pk Ave, Minneapolis, MN 55415 USA-
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Artigos e Materiais de Revistas Científicas - FM/MNE
Departamento de Neurologia - FM/MNE

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia

Artigos e Materiais de Revistas Científicas - LIM/26
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

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