Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/14065
Title: Antibiotic Prophylaxis for Prevention of Febrile Urinary Tract Infections in Children with Vesicoureteral Reflux: A Meta-Analysis of Randomized, Controlled Trials Comparing Dilated to Nondilated Vesicoureteral Reflux
Authors: BESSA JR., Jose deMRAD, Flavia Cristina de CarvalhoMENDES, Evilin FeitosaBESSA, Marcia CarvalhoPASCHOALIN, Victor PereiraTIRABOSCHI, Ricardo BrianeziSAMMOUR, Zein MohamedGOMES, Cristiano MendesBRAGA, Luis H.NETTO, Jose Murillo Bastos
Citation: JOURNAL OF UROLOGY, v.193, n.5, suppl.S, p.1772-1777, 2015
Abstract: Purpose: The followup and treatment of children with vesicoureteral reflux has been debated for many years. Antibiotic prophylaxis has a role for preventing urinary tract infection in these children. Recent studies and guidelines suggested that prophylaxis has little or no role in preventing urinary tract infection in those children, especially those with low grades (I and II) of reflux. Materials and Methods: We analyzed all published randomized, controlled trials comparing antibiotic prophylaxis vs no prophylaxis or placebo in children with vesicoureteral reflux. The children were divided into those with nondilated (grades I and II) and dilated (grades III and IV) vesicoureteral reflux. After data were analyzed the RIVUR study was published and, therefore, it was added to the analyzed data. Results: After analyzing the first published studies we found that antibiotic prophylaxis would be beneficial only in children with high grade vesicoureteral reflux. With the addition of the data in the RIVUR study these results changed. The new pooled data support antibiotic prophylaxis in all children with vesicoureteral reflux. Conclusions: Vesicoureteral reflux management is still controversial. In contrast to recently published studies and guidelines, this meta-analysis supports antibiotic prophylaxis in all children with vesicoureteral reflux regardless of reflux grade. More studies are needed to support this finding.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IOT
Instituto de Ortopedia e Traumatologia - HC/IOT

Artigos e Materiais de Revistas Científicas - LIM/55
LIM/55 - Laboratório de Urologia


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