Unilateral Hand-Foot Syndrome: Does It Take Sides? Case Report and Literature Review

Abstract

The association between hand-foot syndrome and fluoropyrimidines is well documented in the medical literature. Its etiology is obscure, with a few pathophysiology hypotheses being postulated. Classic hand-foot syndrome is characterized by dermatologic symmetric findings. This is the first case report of unilateral hand-foot syndrome in a patient with colorectal cancer who received capecitabine. Here we discuss possible causes of hand-foot syndrome, bringing new elements to clarify the mechanisms involved in this intriguing adverse effect.