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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBECKER, Jefferson-
dc.contributor.authorCALLEGARO, Dagoberto-
dc.contributor.authorLANA-PEIXOTO, Marco Aurelio-
dc.contributor.authorTALIM, Natalia-
dc.contributor.authorVIDALETTI, Tamara-
dc.contributor.authorCORREA, Marcelo de Paula-
dc.contributor.authorGOMES, Irenio-
dc.date.accessioned2016-07-18T12:31:27Z-
dc.date.available2016-07-18T12:31:27Z-
dc.date.issued2016-
dc.identifier.citationJOURNAL OF THE NEUROLOGICAL SCIENCES, v.363, p.236-239, 2016-
dc.identifier.issn0022-510X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14451-
dc.description.abstractMultiple sclerosis (MS) onset is believed to result from a combination of environmental and genetic factors. A prevailing theory addresses the influence of hypovitaminosis D in the development of MS. This research aimed to study the association between vitamin D serum levels and MS, as a prognostic and risk factor for the development and progression of the disease. A cross-sectional multicenter study was conducted in patients with relapsing-remitting MS (n = 67), according to the revised McDonald criteria (2010), accompanied in three MS centers in different Brazilian states. A control group consisted of healthy volunteers (n = 61). Blood collections were carried out in late summer and late winter. This seems to be the first study of this kind in Latin America. The vitamin D serum levels for MS patients (29.63 +/- 8.08) in summer were similar to the controls (29.71 +/- 8.28); however, in winter they were lower than the healthy individuals (24.05 +/- 7.47 vs 26.56 +/- 8.01). No significant difference between the three cities was observed. No association was noted between vitamin D serum levels and gender, race and age, nor correlation of these levels with the EDSS or disease duration. In contrast, a significant association was seen between deficient vitamin D serum levels in late winter with disease activity, characterized by the onset of relapses (19.73 +/- 5.69 vs 25.30 +/- 6.22) or Gd + lesions (17.22 +/- 3.11 vs 22.79 +/- 7.22).-
dc.description.sponsorshipNovartis-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE BV-
dc.relation.ispartofJournal of the Neurological Sciences-
dc.rightsrestrictedAccess-
dc.subjectMultiple sclerosis-
dc.subjectDemyelinating inflammatory disease-
dc.subjectRisk factor-
dc.subjectVitamin D-
dc.subjectHypovitaminosis-
dc.subjectMS epidemiology-
dc.subject.othervitamin-d status-
dc.subject.otherrisk-
dc.subject.otherhealth-
dc.titleHypovitaminosis D association with disease activity in relapsing remitting multiple sclerosis in Brazil-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.identifier.doi10.1016/j.jns.2016.02.064-
dc.identifier.pmid27000256-
dc.subject.wosClinical Neurology-
dc.subject.wosNeurosciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalBECKER, Jefferson:Pontifical Catholic Univ Rio Grande Sul PUCRS, Neuroimmunol Program, Hosp Sao Lucas, Porto Alegre, RS, Brazil-
hcfmusp.author.externalLANA-PEIXOTO, Marco Aurelio:Univ Fed Minas Gerais, Multiple Sclerosis Res Ctr CIEM, Belo Horizonte, MG, Brazil-
hcfmusp.author.externalTALIM, Natalia:Univ Fed Minas Gerais, Multiple Sclerosis Res Ctr CIEM, Belo Horizonte, MG, Brazil-
hcfmusp.author.externalVIDALETTI, Tamara:Pontifical Catholic Univ Rio Grande Sul PUCRS, Neuroimmunol Program, Hosp Sao Lucas, Porto Alegre, RS, Brazil-
hcfmusp.author.externalCORREA, Marcelo de Paula:Fed Univ Itajuba Unifei, Nat Resources Inst, Itajuba, Brazil-
hcfmusp.author.externalGOMES, Irenio:Pontifical Catholic Univ Rio Grande Sul PUCRS, Neuroimmunol Program, Hosp Sao Lucas, Porto Alegre, RS, Brazil-
hcfmusp.description.beginpage236-
hcfmusp.description.endpage239-
hcfmusp.description.volume363-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000374078200046-
hcfmusp.origem.id2-s2.0-84959535931-
hcfmusp.publisher.cityAMSTERDAM-
hcfmusp.publisher.countryNETHERLANDS-
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dc.description.indexMEDLINE-
dc.identifier.eissn1878-5883-
hcfmusp.citation.scopus8-
hcfmusp.scopus.lastupdate2022-07-08-
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica


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