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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBECKER, Jefferson-
dc.contributor.authorCALLEGARO, Dagoberto-
dc.contributor.authorLANA-PEIXOTO, Marco Aurelio-
dc.contributor.authorTALIM, Natalia-
dc.contributor.authorVIDALETTI, Tamara-
dc.contributor.authorCORREA, Marcelo de Paula-
dc.contributor.authorGOMES, Irenio-
dc.identifier.citationJOURNAL OF THE NEUROLOGICAL SCIENCES, v.363, p.236-239, 2016-
dc.description.abstractMultiple sclerosis (MS) onset is believed to result from a combination of environmental and genetic factors. A prevailing theory addresses the influence of hypovitaminosis D in the development of MS. This research aimed to study the association between vitamin D serum levels and MS, as a prognostic and risk factor for the development and progression of the disease. A cross-sectional multicenter study was conducted in patients with relapsing-remitting MS (n = 67), according to the revised McDonald criteria (2010), accompanied in three MS centers in different Brazilian states. A control group consisted of healthy volunteers (n = 61). Blood collections were carried out in late summer and late winter. This seems to be the first study of this kind in Latin America. The vitamin D serum levels for MS patients (29.63 +/- 8.08) in summer were similar to the controls (29.71 +/- 8.28); however, in winter they were lower than the healthy individuals (24.05 +/- 7.47 vs 26.56 +/- 8.01). No significant difference between the three cities was observed. No association was noted between vitamin D serum levels and gender, race and age, nor correlation of these levels with the EDSS or disease duration. In contrast, a significant association was seen between deficient vitamin D serum levels in late winter with disease activity, characterized by the onset of relapses (19.73 +/- 5.69 vs 25.30 +/- 6.22) or Gd + lesions (17.22 +/- 3.11 vs 22.79 +/- 7.22).-
dc.relation.ispartofJournal of the Neurological Sciences-
dc.subjectMultiple sclerosis-
dc.subjectDemyelinating inflammatory disease-
dc.subjectRisk factor-
dc.subjectVitamin D-
dc.subjectMS epidemiology-
dc.subject.othervitamin-d status-
dc.titleHypovitaminosis D association with disease activity in relapsing remitting multiple sclerosis in Brazil-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.subject.wosClinical Neurology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Jefferson:Pontifical Catholic Univ Rio Grande Sul PUCRS, Neuroimmunol Program, Hosp Sao Lucas, Porto Alegre, RS, Brazil-, Marco Aurelio:Univ Fed Minas Gerais, Multiple Sclerosis Res Ctr CIEM, Belo Horizonte, MG, Brazil-, Natalia:Univ Fed Minas Gerais, Multiple Sclerosis Res Ctr CIEM, Belo Horizonte, MG, Brazil-, Tamara:Pontifical Catholic Univ Rio Grande Sul PUCRS, Neuroimmunol Program, Hosp Sao Lucas, Porto Alegre, RS, Brazil-, Marcelo de Paula:Fed Univ Itajuba Unifei, Nat Resources Inst, Itajuba, Brazil-, Irenio:Pontifical Catholic Univ Rio Grande Sul PUCRS, Neuroimmunol Program, Hosp Sao Lucas, Porto Alegre, RS, Brazil-
hcfmusp.relation.referenceCorrea MD, 2013, INT J DERMATOL, V52, P966, DOI 10.1111/j.1365-4632.2012.05834.x-
hcfmusp.relation.referencede Abreu DAF, 2009, MULT SCLER, V15, P1146, DOI 10.1177/1352458509106780-
hcfmusp.relation.referenceCorrea MD, 2010, PHOTOCHEM PHOTOBIOL, V86, P438, DOI 10.1111/j.1751-1097.2009.00659.x-
hcfmusp.relation.referenceBRAIDMAN IP, 1985, CLIN ENDOCRINOL, V23, P445, DOI 10.1111/j.1365-2265.1985.tb01103.x-
hcfmusp.relation.referenceRosecrans R, 2014, CLIN BIOCHEM, V47, P670, DOI 10.1016/j.clinbiochem.2014.02.004-
hcfmusp.relation.referenceSouberbielle JC, 2001, J CLIN ENDOCR METAB, V86, P3086, DOI 10.1210/jc.86.7.3086-
hcfmusp.relation.referenceAscherio A, 2014, JAMA NEUROL, V71, P306, DOI 10.1001/jamaneurol.2013.5993-
hcfmusp.relation.referenceThouvenot E, 2015, EUR J NEUROL, V22, P564, DOI 10.1111/ene.12617-
hcfmusp.relation.referenceMartinelli V, 2014, MULT SCLER J, V20, P147, DOI 10.1177/1352458513494959-
hcfmusp.relation.referenceDuan SR, 2014, NEUROSCI LETT, V570, P108, DOI 10.1016/j.neulet.2014.04.021-
hcfmusp.relation.referenceMilo R, 2010, AUTOIMMUN REV, V9, pA387, DOI 10.1016/j.autrev.2009.11.010-
hcfmusp.relation.referenceNiino M, 2015, J NEUROIMMUNOL, V279, P40, DOI 10.1016/j.jneuroim.2015.01.007-
hcfmusp.relation.referenceHiremath GS, 2009, MULT SCLER, V15, P735, DOI 10.1177/1352458509102844-
hcfmusp.relation.referenceWang SH, 2009, NUTR RES REV, V22, P188, DOI 10.1017/S0954422409990151-
hcfmusp.relation.referenceMalik MT, 2014, NEUROLOGY, V82, P2173, DOI 10.1212/WNL.0000000000000524-
hcfmusp.relation.referenceGăleanu Corina, 2014, Rev Med Chir Soc Med Nat Iasi, V118, P327-
hcfmusp.relation.referenceHatamian Hamidreza, 2013, Iran J Neurol, V12, P41-
hcfmusp.relation.referenceKarczmarewicz Elżbieta, 2013, Dermatoendocrinol, V5, P1, DOI 10.4161/derm.25531-
hcfmusp.relation.referencePierrot-Deseilligny C, 2010, BRAIN, V133, P1869, DOI 10.1093/brain/awq147-
hcfmusp.relation.referencePremaor Melissa Orlandin, 2006, Arq Bras Endocrinol Metabol, V50, P25, DOI 10.1590/S0004-27302006000100005-
hcfmusp.relation.referenceRamagopalan SV, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000369-
hcfmusp.relation.referenceZadshir A, 2005, ETHN DIS S5, V15, P97-
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

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