Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorKUHN, Patricia C.-
dc.contributor.authorHORIMOTO, Andrea R. V. Russo-
dc.contributor.authorSANCHES, Jose Mauricio-
dc.contributor.authorVIEIRA FILHO, Joao Paulo B.-
dc.contributor.authorFRANCO, Luciana-
dc.contributor.authorFABBRO, Amaury Dal-
dc.contributor.authorFRANCO, Laercio Joel-
dc.contributor.authorPEREIRA, Alexandre C.-
dc.contributor.authorMOISES, Regina S.-
dc.identifier.citationPLOS ONE, v.7, n.8, article ID e42702, 6p, 2012-
dc.description.abstractCharacterization of population genetic variation and structure can be used as tools for research in human genetics and population isolates are of great interest. The aim of the present study was to characterize the genetic structure of Xavante Indians and compare it with other populations. The Xavante, an indigenous population living in Brazilian Central Plateau, is one of the largest native groups in Brazil. A subset of 53 unrelated subjects was selected from the initial sample of 300 Xavante Indians. Using 86,197 markers, Xavante were compared with all populations of HapMap Phase III and HGDP-CEPH projects and with a Southeast Brazilian population sample to establish its population structure. Principal Components Analysis showed that the Xavante Indians are concentrated in the Amerindian axis near other populations of known Amerindian ancestry such as Karitiana, Pima, Surui and Maya and a low degree of genetic admixture was observed. This is consistent with the historical records of bottlenecks experience and cultural isolation. By calculating pair-wise F-st statistics we characterized the genetic differentiation between Xavante Indians and representative populations of the HapMap and from HGDP-CEPH project. We found that the genetic differentiation between Xavante Indians and populations of Ameridian, Asian, European, and African ancestry increased progressively. Our results indicate that the Xavante is a population that remained genetically isolated over the past decades and can offer advantages for genome-wide mapping studies of inherited disorders.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)-
dc.description.sponsorshipINCT- Obesidade e Diabetes-
dc.relation.ispartofPlos One-
dc.subject.otheramerican y-chromosomes-
dc.titleGenome-Wide Analysis in Brazilian Xavante Indians Reveals Low Degree of Admixture-
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE-
dc.subject.wosMultidisciplinary Sciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Patricia C.:Univ Fed Sao Paulo, Disciplina Endocrinol, Escola Paulista Med, Sao Paulo, Brazil- FILHO, Joao Paulo B.:Univ Fed Sao Paulo, Disciplina Endocrinol, Escola Paulista Med, Sao Paulo, Brazil-, Luciana:Univ Fed Sao Paulo, Disciplina Endocrinol, Escola Paulista Med, Sao Paulo, Brazil-, Amaury Dal:Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, Ribeirao Preto, Brazil-, Laercio Joel:Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, Ribeirao Preto, Brazil-, Regina S.:Univ Fed Sao Paulo, Disciplina Endocrinol, Escola Paulista Med, Sao Paulo, Brazil-
hcfmusp.publisher.citySAN FRANCISCO-
hcfmusp.relation.referenceBingham J, 2000, BIOINFORMATICS, V16, P660, DOI 10.1093/bioinformatics/16.7.660-
hcfmusp.relation.referenceCavalli-Sforza LL, 2003, NAT GENET, V33, P266, DOI 10.1038/ng1113-
hcfmusp.relation.referenceCoimbra Jr CEA, 2002, XAVANT TRANSITION HL-
hcfmusp.relation.referenceFriedrich DC, 2012, AM J PHYS ANTHROPOL, V147, P427, DOI 10.1002/ajpa.22010-
hcfmusp.relation.referenceGarfield S., 2001, INDIGENOUS STRUGGLE-
hcfmusp.relation.referenceGiolo SR, 2012, EUR J HUM GENET, V20, P111, DOI 10.1038/ejhg.2011.144-
hcfmusp.relation.referenceAltshuler DM, 2010, NATURE, V467, P52, DOI 10.1038/nature09298-
hcfmusp.relation.referenceJorde LB, 2000, HUM HERED, V50, P57, DOI 10.1159/000022891-
hcfmusp.relation.referenceKalinowski ST, 2006, MOL ECOL NOTES, V6, P576, DOI 10.1111/j.1471-8286.2006.01256.x-
hcfmusp.relation.referenceKolman CJ, 1996, GENETICS, V142, P1321-
hcfmusp.relation.referenceKristiansson K, 2008, GENOME BIOL, V9, P1091-
hcfmusp.relation.referenceLi JZ, 2008, SCIENCE, V319, P1100, DOI 10.1126/science.1153717-
hcfmusp.relation.referenceMulligan CJ, 2004, ANNU REV GENOM HUM G, V5, P295, DOI 10.1146/annurev.genom.5.061903.175920-
hcfmusp.relation.referenceNell JV, 1964, AM J HUM GENET, V16, P52-
hcfmusp.relation.referencePeltonen L, 2000, NAT REV GENET, V1, P182, DOI 10.1038/35042049-
hcfmusp.relation.referencePereira NDM, 2009, HUM ORGAN, V68, P166-
hcfmusp.relation.referencePrice AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847-
hcfmusp.relation.referencePurcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795-
hcfmusp.relation.referenceRosenberg NA, 2002, SCIENCE, V298, P2381, DOI 10.1126/science.1078311-
hcfmusp.relation.referenceSalzano FM, 1997, AM J PHYS ANTHROPOL, V104, P23, DOI 10.1002/(SICI)1096-8644(199709)104:1<23::AID-AJPA2>3.0.CO;2-E-
hcfmusp.relation.referenceSantos FR, 1999, AM J HUM GENET, V64, P619, DOI 10.1086/302242-
hcfmusp.relation.referenceSheffield VC, 1998, TRENDS GENET, V14, P391, DOI 10.1016/S0168-9525(98)01556-X-
hcfmusp.relation.referenceTamm E, 2007, PLOS ONE, V9, P1-
hcfmusp.relation.referenceTishkoff SA, 2003, ANNU REV GENOM HUM G, V4, P293, DOI 10.1146/annurev.genom.4.070802.110226-
hcfmusp.relation.referenceWang S, 2007, PLOS GENET, V3, P2049, DOI 10.1371/journal.pgen.0030185-
hcfmusp.relation.referenceWard RH, 1996, AM J HUM BIOL, V8, P317, DOI 10.1002/(SICI)1520-6300(1996)8:3<317::AID-AJHB2>3.0.CO;2-X-
hcfmusp.relation.referenceZegura SL, 2004, MOL BIOL EVOL, V21, P164, DOI 10.1093/molbev/msh009-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/13
LIM/13 - Laboratório de Genética e Cardiologia Molecular

Files in This Item:
File Description SizeFormat 
art_HORIMOTO_Genome_Wide_Analysis_in_Brazilian_Xavante_Indians_Reveals_2012.PDFpublishedVersion (English)400.34 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.