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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | STEIN, Anna | - |
dc.contributor.author | GOLDMEIER, Silvia | - |
dc.contributor.author | VOLTOLINI, Sarah | - |
dc.contributor.author | SETOGUTTI, Enio | - |
dc.contributor.author | FELDMAN, Carlos | - |
dc.contributor.author | FIGUEIREDO, Eduardo | - |
dc.contributor.author | EICK, Renato | - |
dc.contributor.author | IRIGOYEN, Maria | - |
dc.contributor.author | RIGATTO, Katya | - |
dc.date.accessioned | 2013-07-30T17:52:41Z | - |
dc.date.available | 2013-07-30T17:52:41Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | CLINICS, v.67, n.7, p.761-765, 2012 | - |
dc.identifier.issn | 1807-5932 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1539 | - |
dc.description.abstract | OBJECTIVE: The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients. METHOD: R2(star) quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50 +/- 5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2(star)/T-2(star) images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2(star) maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean +/- standard deviation) followed by the Tukey test. ClinicalTrials.gov: NCT01545479. RESULTS: A significant difference (p<0.001) in renal oxygenation (R2(star)) was observed in the cortex and medulla before and after captopril administration: right kidney, cortex = 11.08 +/- 0.56ms, medulla = 17.21 +/- 1.47ms and cortex = 10.30 +/- 0.44ms, medulla = 16.06 +/- 1.74ms, respectively; and left kidney, cortex = 11.79 +/- 1.85ms, medulla = 17.03 +/- 0.88ms and cortex = 10.89 +/- 0.91ms, medulla = 16.43 +/- 1.49ms, respectively. CONCLUSIONS: This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets. | - |
dc.language.iso | eng | - |
dc.publisher | HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.relation.ispartof | Clinics | - |
dc.rights | openAccess | - |
dc.subject | BOLD | - |
dc.subject | Renal Oxygenation | - |
dc.subject | Healthy Subjects | - |
dc.subject | Captopril | - |
dc.subject | Renin-Angiotensin System | - |
dc.subject.other | chronic kidney-disease | - |
dc.subject.other | bold-mri | - |
dc.subject.other | water diuresis | - |
dc.subject.other | tubulointerstitial injury | - |
dc.subject.other | intrarenal oxygenation | - |
dc.subject.other | medullary oxygenation | - |
dc.subject.other | magnetic-resonance | - |
dc.subject.other | tissue angiotensin | - |
dc.subject.other | chronic hypoxia | - |
dc.subject.other | prevention | - |
dc.title | Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition | - |
dc.type | article | - |
dc.rights.holder | Copyright HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.identifier.doi | 10.6061/clinics/2012(07)10 | - |
dc.identifier.pmid | 22892920 | - |
dc.subject.wos | Medicine, General & Internal | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | STEIN, Anna:Fundacao Univ Cardiol IC FUC, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil; Univ Fed Sao Paulo UNIFESP, Sao Paulo, Brazil | - |
hcfmusp.author.external | GOLDMEIER, Silvia:Fundacao Univ Cardiol IC FUC, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | VOLTOLINI, Sarah:Fundacao Univ Cardiol IC FUC, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | SETOGUTTI, Enio:Serv Invest Diagnost SIDI, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | FELDMAN, Carlos:Fundacao Univ Cardiol IC FUC, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil; Serv Invest Diagnost SIDI, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | FIGUEIREDO, Eduardo:MR Res Latin Amer GE Healthcare, Sao Paulo, Brazil | - |
hcfmusp.author.external | EICK, Renato:Fundacao Univ Cardiol IC FUC, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | RIGATTO, Katya:UFCSPA, Dept Ciencias Basicas Saude, Porto Alegre, RS, Brazil | - |
hcfmusp.description.beginpage | 761 | - |
hcfmusp.description.endpage | 765 | - |
hcfmusp.description.issue | 7 | - |
hcfmusp.description.volume | 67 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84867069551 | - |
hcfmusp.origem.id | WOS:000307723100010 | - |
hcfmusp.origem.id | SCIELO:S1807-59322012000700010 | - |
hcfmusp.publisher.city | SAO PAULO | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 6 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/59 |
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