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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | FERRAREZI, Daniela A. F. | - |
dc.contributor.author | BELLILI-MUNOZ, Naima | - |
dc.contributor.author | NICOLAU, Christiane | - |
dc.contributor.author | CHEURFA, Nadir | - |
dc.contributor.author | GUAZZELLI, Isabel C. | - |
dc.contributor.author | FRAZZATTO, Eliana | - |
dc.contributor.author | VELHO, Gilberto | - |
dc.contributor.author | VILLARES, Sandra M. | - |
dc.date.accessioned | 2013-07-30T17:53:34Z | - |
dc.date.available | 2013-07-30T17:53:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.61, n.10, p.1413-1421, 2012 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1555 | - |
dc.description.abstract | Polymorphisms in the VDR gene were reported to be associated with variations in intrauterine and postnatal growth and with adult height, but also with other traits that are strongly correlated such as the BMI, insulin sensitivity, insulin secretion and hyperglycemia. Here, we assessed the impact of VDR polymorphisms on body height and its interactions with obesity- and glucose tolerance-related traits in obese children and adolescents. We studied 173 prepubertal (Tanner's stage 1) and 146 pubertal (Tanner's stages 2-5) obese children who were referred for a weight-loss program. Three single nucleotide polymorphisms were genotyped: rs1544410 (BsmI), rs7975232 (ApaI) and rs731236 (TaqI). BsmI and TaqI genotypes were significantly associated with height in pubertal children, but the associations did not reach statistical significance in prepubertal children. In stepwise regression analyses, the lean body mass, insulin secretion, BsmI or TaqI genotypes and the father's and the mother's height were independently and positively associated with height in pubertal children. These covariables accounted for 46% of the trait variance. The height of homozygous carriers of the minor allele of BsmI was 0.65 z-scores (4 cm) higher than the height of homozygous carriers of the major allele (P=.0006). Haplotype analyses confirmed the associations of the minor alleles of BsmI and TaqI with increased height. In conclusion, VDR genotypes were significantly associated with height in pubertal obese children. The associations were independent from the effects of confounding traits, such as the body fat mass, insulin secretion, insulin sensitivity and glucose tolerance. | - |
dc.description.sponsorship | FAPESP, Brazil | - |
dc.description.sponsorship | Societe Francophone du Diabete (SFD - Alfediam) | - |
dc.description.sponsorship | Association Diabete Risque Vasculaire (ADRV), France | - |
dc.description.sponsorship | CNPq, Brazil | - |
dc.language.iso | eng | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.relation.ispartof | Metabolism-Clinical and Experimental | - |
dc.rights | restrictedAccess | - |
dc.subject | Child | - |
dc.subject | Adolescent | - |
dc.subject | VDR gene | - |
dc.subject | Obesity | - |
dc.subject | Insulin Secretion | - |
dc.subject.other | genome-wide association | - |
dc.subject.other | d endocrine-system | - |
dc.subject.other | linkage disequilibrium | - |
dc.subject.other | biological pathways | - |
dc.subject.other | bangladeshi asians | - |
dc.subject.other | metabolic syndrome | - |
dc.subject.other | pubertal changes | - |
dc.subject.other | common variants | - |
dc.subject.other | adult stature | - |
dc.subject.other | body height | - |
dc.title | Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents | - |
dc.type | article | - |
dc.rights.holder | Copyright W B SAUNDERS CO-ELSEVIER INC | - |
dc.identifier.doi | 10.1016/j.metabol.2012.03.018 | - |
dc.identifier.pmid | 22551951 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | BELLILI-MUNOZ, Naima:INSERM, Res Unit 695, Paris, France | - |
hcfmusp.author.external | NICOLAU, Christiane:Univ Sao Paulo, Hosp Clin Fac Med, Lab Human Nutr & Metab Dis LIM 25, BR-01246903 Sao Paulo, Brazil | - |
hcfmusp.author.external | CHEURFA, Nadir:INSERM, Res Unit 695, Paris, France | - |
hcfmusp.author.external | VELHO, Gilberto:INSERM, Res Unit 695, Paris, France | - |
hcfmusp.description.beginpage | 1413 | - |
hcfmusp.description.endpage | 1421 | - |
hcfmusp.description.issue | 10 | - |
hcfmusp.description.volume | 61 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000309625900011 | - |
hcfmusp.origem.id | 2-s2.0-84866738522 | - |
hcfmusp.publisher.city | PHILADELPHIA | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Allen HL, 2010, NATURE, V467, P832, DOI 10.1038/nature09410 | - |
hcfmusp.relation.reference | Asao K, 2006, DIABETES CARE, V29, P1632, DOI 10.2337/dc05-1997 | - |
hcfmusp.relation.reference | BARGERLUX MJ, 1995, CALCIFIED TISSUE INT, V57, P161, DOI 10.1007/BF00298438 | - |
hcfmusp.relation.reference | Cole TJ, 2000, P NUTR SOC, V59, P317, DOI 10.1017/S0029665100000355 | - |
hcfmusp.relation.reference | Cooper JD, 2011, DIABETES, V60, P1624, DOI 10.2337/db10-1656 | - |
hcfmusp.relation.reference | Deram S, 2008, J CLIN ENDOCR METAB, V93, P4933, DOI 10.1210/jc.2008-0947 | - |
hcfmusp.relation.reference | Fang Y, 2005, AM J HUM GENET, V77, P807, DOI 10.1086/497438 | - |
hcfmusp.relation.reference | Fang Y, 2007, J CLIN ENDOCR METAB, V92, P1491, DOI 10.1201/jc.2006-1134 | - |
hcfmusp.relation.reference | Genuth S, 2003, DIABETES CARE, V26, P3160 | - |
hcfmusp.relation.reference | Goltzman D, 2010, ANN NY ACAD SCI, V1192, P145, DOI 10.1111/j.1749-6632.2009.05226.x | - |
hcfmusp.relation.reference | Grundberg E, 2004, EUR J ENDOCRINOL, V150, P323, DOI 10.1530/eje.0.1500323 | - |
hcfmusp.relation.reference | Gudbjartsson DF, 2008, NAT GENET, V40, P609, DOI 10.1038/ng.122 | - |
hcfmusp.relation.reference | Hitman GA, 1998, DIABETES, V47, P688, DOI 10.2337/diabetes.47.4.688 | - |
hcfmusp.relation.reference | Hunter D, 2001, J BONE MINER RES, V16, P371, DOI 10.1359/jbmr.2001.16.2.371 | - |
hcfmusp.relation.reference | Ingles SA, 1997, CANCER EPIDEM BIOMAR, V6, P93 | - |
hcfmusp.relation.reference | Jain R, 2012, METABOLISM, V61, P293, DOI 10.1016/j.metabol.2011.06.018 | - |
hcfmusp.relation.reference | Johansson A, 2009, HUM MOL GENET, V18, P373, DOI 10.1093/hmg/ddn350 | - |
hcfmusp.relation.reference | Lanktree MB, 2011, AM J HUM GENET, V88, P6, DOI 10.1016/j.ajhg.2010.11.007 | - |
hcfmusp.relation.reference | LEE S, 1994, ENDOCRINOLOGY, V134, P1602, DOI 10.1210/en.134.4.1602 | - |
hcfmusp.relation.reference | Lettre G, 2008, NAT GENET, V40, P584, DOI 10.1038/ng.125 | - |
hcfmusp.relation.reference | Lettre G, 2009, CURR OPIN PEDIATR, V21, P515, DOI 10.1097/MOP.0b013e32832c6dce | - |
hcfmusp.relation.reference | Li HWR, 2011, METABOLISM, V60, P1475, DOI 10.1016/j.metabol.2011.03.002 | - |
hcfmusp.relation.reference | Lorentzon M, 2000, J CLIN ENDOCR METAB, V85, P1666, DOI 10.1210/jc.85.4.1666 | - |
hcfmusp.relation.reference | MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291 | - |
hcfmusp.relation.reference | MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13 | - |
hcfmusp.relation.reference | Martini LA, 2008, NUTR REV, V66, P291, DOI 10.1111/j.1753-4887.2008.00035.x | - |
hcfmusp.relation.reference | Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462 | - |
hcfmusp.relation.reference | McDermott MF, 1997, DIABETOLOGIA, V40, P971, DOI 10.1007/s001250050776 | - |
hcfmusp.relation.reference | Norman AW, 2008, AM J CLIN NUTR, V88, p491S | - |
hcfmusp.relation.reference | Norman AW, 1998, J BONE MINER RES, V13, P1360, DOI 10.1359/jbmr.1998.13.9.1360 | - |
hcfmusp.relation.reference | Nyholt DR, 2004, AM J HUM GENET, V74, P765, DOI 10.1086/383251 | - |
hcfmusp.relation.reference | Ogunkolade BW, 2002, DIABETES, V51, P2294, DOI 10.2337/diabetes.51.7.2294 | - |
hcfmusp.relation.reference | Oh JY, 2002, METABOLISM, V51, P356, DOI 10.1053/meta.2002.29969 | - |
hcfmusp.relation.reference | Parikh SJ, 2004, J CLIN ENDOCR METAB, V89, P1196, DOI 10.1210/jc.2003-031398 | - |
hcfmusp.relation.reference | Pecoraro P, 2003, ACTA DIABETOL, V40, pS278, DOI 10.1007/s00592-003-0086-y | - |
hcfmusp.relation.reference | Pimenta JR, 2006, HUM HERED, V62, P190, DOI 10.1159/000096872 | - |
hcfmusp.relation.reference | Ramagopalan SV, 2010, GENOME RES, V20, P1352, DOI 10.1101/gr.107920.110 | - |
hcfmusp.relation.reference | Reis AF, 2005, DIABETES METAB, V31, P318, DOI 10.1016/S1262-3636(07)70200-8 | - |
hcfmusp.relation.reference | Sanna S, 2008, NAT GENET, V40, P198, DOI 10.1038/ng.74 | - |
hcfmusp.relation.reference | Shea MK, 2009, EUR J CLIN NUTR, V63, P458, DOI 10.1038/sj.ejcn.1602959 | - |
hcfmusp.relation.reference | Silventoinen K, 2003, TWIN RES, V6, P399, DOI 10.1375/136905203770326402 | - |
hcfmusp.relation.reference | Soranzo N, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000445 | - |
hcfmusp.relation.reference | Stumvoll M, 2000, DIABETES CARE, V23, P295, DOI 10.2337/diacare.23.3.295 | - |
hcfmusp.relation.reference | Suarez F, 1997, J CLIN ENDOCR METAB, V82, P2966, DOI 10.1210/jc.82.9.2966 | - |
hcfmusp.relation.reference | Tregouet DA, 2004, ANN HUM GENET, V68, P165, DOI 10.1046/j.1529-8817.2003.00085.x | - |
hcfmusp.relation.reference | Uitterlinden AG, 2004, GENE, V338, P143, DOI 10.1016/j.gene.2004.05.014 | - |
hcfmusp.relation.reference | Vaidya A, 2012, METABOLISM, V61, P450, DOI 10.1016/j.metabol.2011.09.007 | - |
hcfmusp.relation.reference | Vaidya A, 2012, METABOLISM IN PRESS, P61, DOI [10.1016/j.metabol.2011.12.009, DOI 10.1016/J.METABOL.2011.12.009] | - |
hcfmusp.relation.reference | Veldhuis JD, 2005, ENDOCR REV, V26, P114, DOI 10.1210/er.2003-0038 | - |
hcfmusp.relation.reference | Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487 | - |
hcfmusp.relation.reference | WALTERS MR, 1992, ENDOCR REV, V13, P719, DOI 10.1210/er.13.4.719 | - |
hcfmusp.relation.reference | Wang TJ, 2010, LANCET, V376, P180, DOI 10.1016/S0140-6736(10)60588-0 | - |
hcfmusp.relation.reference | Weedon MN, 2007, NAT GENET, V39, P1245, DOI 10.1038/ng2121 | - |
hcfmusp.relation.reference | Weedon MN, 2008, NAT GENET, V40, P575, DOI 10.1038/ng.121 | - |
hcfmusp.relation.reference | Winters SJ, 2009, METABOLISM, V58, P438, DOI 10.1016/j.metabol.2008.10.017 | - |
hcfmusp.relation.reference | Ye WZ, 2001, EUR J ENDOCRINOL, V145, P181, DOI 10.1530/eje.0.1450181 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 23 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/25 |
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