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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | KONAN, Nzi Andre | - |
dc.contributor.author | LINCOPAN, Nilton | - |
dc.contributor.author | DIAZ, Ingrit Elida Collantes | - |
dc.contributor.author | JACYSYN, Jacqueline de Fatima | - |
dc.contributor.author | TIBA, Mirtes Midori Tanae | - |
dc.contributor.author | MENDES, Joao Gustavo Pessini Amarante | - |
dc.contributor.author | BACCHI, Elfriede Marianne | - |
dc.contributor.author | SPIRA, Beny | - |
dc.date.accessioned | 2013-07-30T17:53:38Z | - |
dc.date.available | 2013-07-30T17:53:38Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, v.64, n.5, p.435-440, 2012 | - |
dc.identifier.issn | 0940-2993 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1577 | - |
dc.description.abstract | The leaves of the Cashew plant (Anacardium occidentale L.) are used by the folk medicine in South America and West Africa. This plant is rich in flavonoids, which are polyphenolic compounds widespread in plants, and that have diverse physiological effects. In a sub-acute toxicity assay it was found that an ethanolic extract of Cashew leaves elicited lymphopenia in rats. The extract was also found to be cytotoxic and to induce apoptosis in Jurkat (acute lymphoblastic leukemia) cells. The crude ethanolic extract was fractionated and resolved by HPLC. One of the four fractions obtained led to the isolation of the biflavonoid agasthisflavone. [H-3]-thymidine incorporation assays and flow cytometry analysis showed that the isolated compound displayed a high anti-proliferative effect in Jurkat cells with an IC50 of 2.4 mu g/ml (4.45 mu M). The effect of agathisflavone on the acute promyelocytic leukemia cell line HL60, Burkitt lymphoma Raji cells and Hep-2 laryngeal carcinoma cells was also tested. The two latter ones were only mildly affected by agathisflavone. It is also shown that agathisflavone induces apoptosis in Jurkat cells and it this proposed that this is the likely mechanism of agathisflavone specific cytotoxicity. | - |
dc.description.sponsorship | Bryan Gunn's Leukaemia Appeal (UK) | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER GMBH, URBAN & FISCHER VERLAG | - |
dc.relation.ispartof | Experimental and Toxicologic Pathology | - |
dc.rights | restrictedAccess | - |
dc.subject | Cashew | - |
dc.subject | Rats | - |
dc.subject | Leukemia cells | - |
dc.subject.other | chronic lymphocytic-leukemia | - |
dc.subject.other | t-cells | - |
dc.subject.other | phosphodiesterases | - |
dc.subject.other | biflavonoids | - |
dc.subject.other | apoptosis | - |
dc.subject.other | activation | - |
dc.subject.other | inhibitors | - |
dc.subject.other | toxicity | - |
dc.subject.other | proteins | - |
dc.subject.other | extract | - |
dc.title | Cytotoxicity of cashew flavonoids towards malignant cell lines | - |
dc.type | article | - |
dc.rights.holder | Copyright ELSEVIER GMBH, URBAN & FISCHER VERLAG | - |
dc.identifier.doi | 10.1016/j.etp.2010.10.010 | - |
dc.identifier.pmid | 21106357 | - |
dc.subject.wos | Pathology | - |
dc.subject.wos | Toxicology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | KONAN, Nzi Andre:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil | - |
hcfmusp.author.external | LINCOPAN, Nilton:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil | - |
hcfmusp.author.external | DIAZ, Ingrit Elida Collantes:Univ Sao Paulo, Inst Quim, Dept Quim Organ, Sao Paulo, Brazil | - |
hcfmusp.author.external | TIBA, Mirtes Midori Tanae:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farmacol, Sao Paulo, Brazil | - |
hcfmusp.author.external | MENDES, Joao Gustavo Pessini Amarante:Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, Brazil | - |
hcfmusp.author.external | BACCHI, Elfriede Marianne:Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farmacol, Sao Paulo, Brazil | - |
hcfmusp.author.external | SPIRA, Beny:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 435 | - |
hcfmusp.description.endpage | 440 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 64 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000304513300006 | - |
hcfmusp.origem.id | 2-s2.0-84860455346 | - |
hcfmusp.publisher.city | JENA | - |
hcfmusp.publisher.country | GERMANY | - |
hcfmusp.relation.reference | Asirvatham AL, 2004, J IMMUNOL, V173, P4806 | - |
hcfmusp.relation.reference | Chaabi M, 2007, PLANTA MED, V73, P1284, DOI 10.1055/s-2007-990218 | - |
hcfmusp.relation.reference | COLLINS SJ, 1977, NATURE, V270, P347, DOI 10.1038/270347a0 | - |
hcfmusp.relation.reference | Cushnie TPT, 2005, INT J ANTIMICROB AG, V26, P343, DOI 10.1016/j.ijantimicag.2005.09.002 | - |
hcfmusp.relation.reference | de Carvalho M, 2007, INDIAN J PHARM, V39, P184 | - |
hcfmusp.relation.reference | Grynberg NF, 2002, BRAZ J MED BIOL RES, V35, P819, DOI 10.1590/S0100-879X2002000700009 | - |
hcfmusp.relation.reference | Harborne J B, 1986, Prog Clin Biol Res, V213, P15 | - |
hcfmusp.relation.reference | Kaatsch P, 2010, CANCER TREAT REV, V36, P277, DOI 10.1016/j.ctrv.2010.02.003 | - |
hcfmusp.relation.reference | Kim HP, 2008, ARCH PHARM RES, V31, P265, DOI [10.1007/s12272-001-1151-3, 10.1007/s00000-001-1151-3] | - |
hcfmusp.relation.reference | Kirszberg C, 2003, PHYTOTHER RES, V17, P1054, DOI 10.1002/ptr.1297 | - |
hcfmusp.relation.reference | Konan NA, 2007, J ETHNOPHARMACOL, V110, P30, DOI 10.1016/j.jep.2006.08.033 | - |
hcfmusp.relation.reference | Lerner A, 2006, BIOCHEM J, V393, P21, DOI 10.1042/BJ20051368 | - |
hcfmusp.relation.reference | Lincopan N, 2006, EXP TOXICOL PATHOL, V58, P175, DOI 10.1016/j.etp.2006.07.002 | - |
hcfmusp.relation.reference | Lucas DM, 2009, BLOOD, V113, P4656, DOI 10.1182/blood-2008-09-175430 | - |
hcfmusp.relation.reference | Mkounga P, 2009, NAT PROD COMMUN, V4, P803 | - |
hcfmusp.relation.reference | MOORE AE, 1955, CANCER RES, V15, P598 | - |
hcfmusp.relation.reference | Newman DJ, 2007, J NAT PROD, V70, P461, DOI 10.1021/np068054v | - |
hcfmusp.relation.reference | NICOLETTI I, 1991, J IMMUNOL METHODS, V139, P271, DOI 10.1016/0022-1759(91)90198-O | - |
hcfmusp.relation.reference | Pang XF, 2009, CANCER RES, V69, P518, DOI 10.1158/0008-5472.CAN-08-2531 | - |
hcfmusp.relation.reference | Park KH, 2006, BIOORG MED CHEM LETT, V16, P5580, DOI 10.1016/j.bmcl.2006.08.032 | - |
hcfmusp.relation.reference | Perez-Tomas R, 2003, HISTOL HISTOPATHOL, V18, P379 | - |
hcfmusp.relation.reference | PULVERTAFT J V, 1964, Lancet, V1, P238 | - |
hcfmusp.relation.reference | Souza-Fagundes EM, 2003, EXP CELL RES, V290, P420, DOI 10.1016/S0014-4827(03)00350-1 | - |
hcfmusp.relation.reference | Svenningsen AB, 2006, J ETHNOPHARMACOL, V103, P276, DOI 10.1016/j.jep.2005.08.012 | - |
hcfmusp.relation.reference | WEISS A, 1984, J IMMUNOL, V133, P123 | - |
hcfmusp.relation.reference | Zhang LZ, 2008, P NATL ACAD SCI USA, V105, P19532, DOI 10.1073/pnas.0806152105 | - |
hcfmusp.relation.reference | Zhu WH, 1998, LIFE SCI, V63, P265, DOI 10.1016/S0024-3205(98)00270-7 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 41 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/62 |
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