Use este identificador para citar ou linkar para este item: https://observatorio.fm.usp.br/handle/OPI/1612
Título: Role of monocarboxylate transporters in human cancers: state of the art
Autor(es): PINHEIRO, CelineLONGATTO-FILHO, AdhemarAZEVEDO-SILVA, JoaoCASAL, MargaridaSCHMITT, Fernando C.BALTAZAR, Fatima
Parte de: JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, v.44, n.1, p.127-139, 2012
Resumo: Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. The role of MCTs in cell homeostasis has been characterized in detail in normal tissues, however, their role in cancer is still far from understood. Most solid tumors are known to rely on glycolysis for energy production and this activity leads to production of important amounts of lactate, which are exported into the extracellular milieu, contributing to the acidic microenvironment. In this context, MCTs will play a dual role in the maintenance of the hyper-glycolytic acid-resistant phenotype of cancer, allowing the maintenance of the high glycolytic rates by performing lactate efflux, and pH regulation by the co-transport of protons. Thus, they constitute attractive targets for cancer therapy, which have been little explored. Here we review the literature on the role of MCTs in solid tumors in different locations, such as colon, central nervous system, breast, lung, gynecologic tract, prostate, stomach, however, there are many conflicting results and in most cases there are no functional studies showing the dependence of the tumors on MCT expression and activity. Additional studies on MCT expression in other tumor types, confirmation of the results already published as well as additional functional studies are needed to deeply understand the role of MCTs in cancer maintenance and aggressiveness.
Aparece nas coleções:

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática


Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
art_LONGATTO-FILHO_Role_of_monocarboxylate_transporters_in_human_cancers_state_2012.PDF
  Restricted Access
publishedVersion (English)458.37 kBAdobe PDFVisualizar/Abrir    Solicitar uma cópia

Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.