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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBARBEIRO, Denise Frediani-
dc.contributor.authorBARBEIRO, Hermes Vieira-
dc.contributor.authorZAMPIERI, Fernando Godinho-
dc.contributor.authorMACHADO, Marcel Cerqueira Cesar-
dc.contributor.authorTORGGLER FILHO, Francisco-
dc.contributor.authorCUNHA, Debora Maria Gomes-
dc.contributor.authorGOULART, Alessandra Carvalho-
dc.contributor.authorVELASCO, Irineu Tadeu-
dc.contributor.authorCRUZ NETO, Luiz Monteiro da-
dc.contributor.authorSOUZA, Heraldo Possolo de-
dc.contributor.authorSILVA, Fabiano Pinheiro da-
dc.date.accessioned2013-09-23T16:30:07Z-
dc.date.available2013-09-23T16:30:07Z-
dc.date.issued2013-
dc.identifier.citationMICROBES AND INFECTION, v.15, n.5, p.342-346, 2013-
dc.identifier.issn1286-4579-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1697-
dc.description.abstractHost defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/17731-2]-
dc.description.sponsorshipCNPq-
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq) [480109/2010-9]-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE BV-
dc.relation.ispartofMicrobes and Infection-
dc.rightsrestrictedAccess-
dc.subjectCathelicidin-
dc.subjectVitamin D-
dc.subjectInflammation-
dc.subject.otherantimicrobial peptide ll-37-
dc.subject.otherinvasive bacterial-infection-
dc.subject.otherhost-defense-
dc.subject.otherimmune-responses-
dc.subject.otherin-vitro-
dc.subject.otherreceptor-
dc.subject.othersepsis-
dc.subject.otherprotects-
dc.subject.otheractivation-
dc.subject.otherexpression-
dc.titleCathelicidin LL-37 bloodstream surveillance is down regulated during septic shock-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.identifier.doi10.1016/j.micinf.2013.01.001-
dc.identifier.pmid23328115-
dc.subject.wosImmunology-
dc.subject.wosInfectious Diseases-
dc.subject.wosMicrobiology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.description.beginpage342-
hcfmusp.description.endpage346-
hcfmusp.description.issue5-
hcfmusp.description.volume15-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84876857721-
hcfmusp.origem.idWOS:000319539000002-
hcfmusp.publisher.cityAMSTERDAM-
hcfmusp.publisher.countryNETHERLANDS-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.citation.scopus25-
hcfmusp.scopus.lastupdate2022-05-06-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/51
LIM/51 - Laboratório de Emergências Clínicas


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