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Title: Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock
Authors: BARBEIRO, Denise FredianiBARBEIRO, Hermes VieiraZAMPIERI, Fernando GodinhoMACHADO, Marcel Cerqueira CesarTORGGLER FILHO, FranciscoCUNHA, Debora Maria GomesGOULART, Alessandra CarvalhoVELASCO, Irineu TadeuCRUZ NETO, Luiz Monteiro daSOUZA, Heraldo Possolo deSILVA, Fabiano Pinheiro da
Citation: MICROBES AND INFECTION, v.15, n.5, p.342-346, 2013
Abstract: Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/51
LIM/51 - Laboratório de Emergências Clínicas

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