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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BRUNONI, Andre R. | - |
dc.contributor.author | VALIENGO, Leandro | - |
dc.contributor.author | BACCARO, Alessandra | - |
dc.contributor.author | ZANAO, Tamires A. | - |
dc.contributor.author | OLIVEIRA, Janaina F. de | - |
dc.contributor.author | GOULART, Alessandra | - |
dc.contributor.author | BOGGIO, Paulo S. | - |
dc.contributor.author | LOTUFO, Paulo A. | - |
dc.contributor.author | BENSENOR, Isabela M. | - |
dc.contributor.author | FREGNI, Felipe | - |
dc.date.accessioned | 2013-09-23T16:36:01Z | - |
dc.date.available | 2013-09-23T16:36:01Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JAMA PSYCHIATRY, v.70, n.4, p.383-391, 2013 | - |
dc.identifier.issn | 2168-622X | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1731 | - |
dc.description.abstract | Importance: Transcranial direct current stimulation (tDCS) trials for major depressive disorder (MDD) have shown positive but mixed results. Objective: To assess the combined safety and efficacy of tDCS vs a common pharmacological treatment (sertraline hydrochloride, 50 mg/d). Design: Double-blind, controlled trial. Participants were randomized using a 2 x 2 factorial design to sertraline/placebo and active/sham tDCS. Setting: Outpatient, single-center academic setting in Sao Paulo, Brazil. Participants: One hundred twenty antidepressant free patients with moderate to severe, nonpsychotic, unipolar MDD. Interventions: Six-week treatment of 2-mA anodal left/cathodal right prefrontal tDCS (twelve 30-minute sessions: 10 consecutive sessions once daily from Monday to Friday plus 2 extra sessions every other week) and sertraline hydrochloride (50 mg/d). Main Outcome Measures: In this intention-to-treat analysis, the primary outcome measure was the change in Montgomery-Asberg Depression Rating Scale score at 6 weeks (end point). We considered a difference of at least 3 points to be clinically relevant. The analysis plan was previously published. Safety was measured with an adverse effects questionnaire, the Young Mania Rating Scale, and cognitive assessment. Secondary measures were rates of clinical response and remission and scores on other scales. Results: At the main end point, there was a significant difference in Montgomery-Asberg Depression Rating Scale scores when comparing the combined treatment group (sertraline/active tDCS) vs sertraline only (mean difference, 8.5 points; 95% CI, 2.96 to 14.03; P = .002), tDCS only (mean difference, 5.9 points; 95% CI, 0.36 to 11.43; P = .03), and placebo/sham tDCS (mean difference, 11.5 points; 95% CI, 6.03 to 17.10; P < .001). Analysis of tDCS only vs sertraline only presented comparable efficacies (mean difference, 2.6 points; 95% CI, -2.90 to 8.13; P = .35). Use of tDCS only (but not sertraline only) was superior to placebo/sham tDCS. Common adverse effects did not differ between interventions, except for skin redness on the scalp in active tDCS (P = .03). There were 7 episodes of treatment-emergent mania or hypomania, 5 occurring in the combined treatment group. Conclusions and Relevance: In MDD, the combination of tDCS and sertraline increases the efficacy of each treatment. The efficacy and safety of tDCS and sertraline did not differ. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/05728-7, 2011/00212-2] | - |
dc.description.sponsorship | CAPES Foundation, Ministry of Education of Brazil [BEX 2565/11-0] | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) | - |
dc.description.sponsorship | RJG Foundation | - |
dc.language.iso | eng | - |
dc.publisher | AMER MEDICAL ASSOC | - |
dc.relation.ispartof | Jama Psychiatry | - |
dc.rights | restrictedAccess | - |
dc.subject.other | direct-current stimulation | - |
dc.subject.other | transcranial magnetic stimulation | - |
dc.subject.other | sham-controlled trial | - |
dc.subject.other | dorsolateral prefrontal cortex | - |
dc.subject.other | treatment-resistant depression | - |
dc.subject.other | major depression | - |
dc.subject.other | double-blind | - |
dc.subject.other | antidepressant trials | - |
dc.subject.other | brain-stimulation | - |
dc.subject.other | disorder | - |
dc.title | The Sertraline vs Electrical Current Therapy for Treating Depression Clinical Study Results From a Factorial, Randomized, Controlled Trial | - |
dc.type | article | - |
dc.rights.holder | Copyright AMER MEDICAL ASSOC | - |
dc.identifier.doi | 10.1001/2013.jamapsychiatry.32 | - |
dc.identifier.pmid | 23389323 | - |
dc.subject.wos | Psychiatry | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | ZANAO, Tamires A.:Univ Sao Paulo, Inst Psychol, Dept Neurosci & Behav, BR-05508000 Sao Paulo, Brazil | - |
hcfmusp.author.external | OLIVEIRA, Janaina F. de:Univ Sao Paulo, Inst Psychol, Dept Neurosci & Behav, BR-05508000 Sao Paulo, Brazil | - |
hcfmusp.author.external | BOGGIO, Paulo S.:Univ Prebiteriana Mackenzie, Ctr Hlth & Biol Sci, Cognit Neurosci Lab & Dev Disorders Program, Sao Paulo, Brazil | - |
hcfmusp.author.external | FREGNI, Felipe:Univ Sao Paulo, Inst Psychol, Dept Neurosci & Behav, BR-05508000 Sao Paulo, Brazil; Harvard Univ, Sch Med, Spaulding Rehabil Hosp, Lab Neuromodulat, Boston, MA USA; Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA | - |
hcfmusp.description.beginpage | 383 | - |
hcfmusp.description.endpage | 391 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 70 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000320853400004 | - |
hcfmusp.origem.id | 2-s2.0-84876062696 | - |
hcfmusp.publisher.city | CHICAGO | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Anderson IM, 2008, J PSYCHOPHARMACOL, V22, P343, DOI 10.1177/0269881107088441 | - |
hcfmusp.relation.reference | Arul-Anandam AP, 2010, J ECT, V26, P68, DOI 10.1097/YCT.0b013e3181a744bf | - |
hcfmusp.relation.reference | Baeken C, 2010, PROG NEURO-PSYCHOPH, V34, P684, DOI 10.1016/j.pnpbp.2010.03.021 | - |
hcfmusp.relation.reference | Boggio PS, 2008, INT J NEUROPSYCHOPH, V11, P249, DOI 10.1017/S1461145707007833 | - |
hcfmusp.relation.reference | Boutron I, 2008, ANN INTERN MED, V148, P295 | - |
hcfmusp.relation.reference | Brakemeier EL, 2008, J AFFECT DISORDERS, V108, P59, DOI 10.1016/j.jad.2007.09.007 | - |
hcfmusp.relation.reference | Brunoni AR, 2010, ARQ NEURO-PSIQUIAT, V68, P433, DOI 10.1590/S0004-282X2010000300021 | - |
hcfmusp.relation.reference | Brunoni AR, 2011, PROG NEURO-PSYCHOPH, V35, P96, DOI 10.1016/j.pnpbp.2010.09.010 | - |
hcfmusp.relation.reference | Brunoni AR, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004824 | - |
hcfmusp.relation.reference | Brunoni AR, 2011, CONTEMP CLIN TRIALS, V32, P90, DOI 10.1016/j.cct.2010.09.007 | - |
hcfmusp.relation.reference | Brunoni AR, 2011, INT J NEUROPSYCHOPH, V14, P1133, DOI 10.1017/S1461145710001690 | - |
hcfmusp.relation.reference | Brunoni AR, 2011, EXPERT REV MED DEVIC, V8, P31, DOI [10.1586/erd.10.62, 10.1586/ERD.10.62] | - |
hcfmusp.relation.reference | Brunoni AR, 2012, BRAIN STIMUL, V5, P175, DOI 10.1016/j.brs.2011.03.002 | - |
hcfmusp.relation.reference | Brunoni AR, 2011, J NEUROPSYCH CLIN N, V23, pE4, DOI 10.1176/appi.neuropsych.23.3.E4 | - |
hcfmusp.relation.reference | Brunoni Andre R, 2009, Ther Clin Risk Manag, V5, P897 | - |
hcfmusp.relation.reference | Chaieb L, 2008, VISUAL NEUROSCI, V25, P77, DOI 10.1017/S0952523808080097 | - |
hcfmusp.relation.reference | Cipriani A, 2009, LANCET, V373, P746, DOI 10.1016/S0140-6736(09)60046-5 | - |
hcfmusp.relation.reference | Cipriani A, 2010, COCHRANE DB SYST REV, V4 | - |
hcfmusp.relation.reference | DaSilva AF, 2011, J VIS EXP, P2744 | - |
hcfmusp.relation.reference | Dell'Osso B, 2012, EUR PSYCHIAT, V27, P513, DOI 10.1016/j.eurpsy.2011.02.008 | - |
hcfmusp.relation.reference | Fergusson D, 2004, BRIT MED J, V328, P432, DOI 10.1136/bmj.37952.631667.EE | - |
hcfmusp.relation.reference | Ferrucci R, 2009, J AFFECT DISORDERS, V118, P215, DOI 10.1016/j.jad.2009.02.015 | - |
hcfmusp.relation.reference | Ferrucci R, 2009, CLIN NEUROPSYCHIATRY, V6, P246 | - |
hcfmusp.relation.reference | Fregni F, 2006, INT J NEUROPSYCHOPH, V9, P641, DOI 10.1017/S1461145705006280 | - |
hcfmusp.relation.reference | Fregni F, 2006, BIPOLAR DISORD, V8, P203, DOI 10.1111/j.1399-5618.2006.00291.x | - |
hcfmusp.relation.reference | Galvez V, 2011, J ECT, V27, P256, DOI 10.1097/YCT.0b013e3182012b89 | - |
hcfmusp.relation.reference | Gandiga PC, 2006, CLIN NEUROPHYSIOL, V117, P845, DOI 10.1016/j.clinph.2005.12.003 | - |
hcfmusp.relation.reference | George MS, 2010, ARCH GEN PSYCHIAT, V67, P507, DOI 10.1001/archgenpsychiatry.2010.46 | - |
hcfmusp.relation.reference | Heo M, 2009, INT J GERIATR PSYCH, V24, P990, DOI 10.1002/gps.2211 | - |
hcfmusp.relation.reference | Kalu UG, 2012, PSYCHOL MED, V42, P1791, DOI 10.1017/S0033291711003059 | - |
hcfmusp.relation.reference | Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095 | - |
hcfmusp.relation.reference | Koenigs M, 2009, BEHAV BRAIN RES, V201, P239, DOI 10.1016/j.bbr.2009.03.004 | - |
hcfmusp.relation.reference | Liebetanz D, 2002, BRAIN, V125, P2238, DOI 10.1093/brain/awf238 | - |
hcfmusp.relation.reference | Lisanby SH, 2009, NEUROPSYCHOPHARMACOL, V34, P522, DOI 10.1038/npp.2008.118 | - |
hcfmusp.relation.reference | Loo CK, 2012, BRIT J PSYCHIAT, V200, P52, DOI 10.1192/bjp.bp.111.097634 | - |
hcfmusp.relation.reference | Loo CK, 2010, INT J NEUROPSYCHOPH, V13, P61, DOI 10.1017/S1461145709990411 | - |
hcfmusp.relation.reference | Martin DM, 2011, J AFFECT DISORDERS, V134, P459, DOI 10.1016/j.jad.2011.05.018 | - |
hcfmusp.relation.reference | McAlister FA, 2003, JAMA-J AM MED ASSOC, V289, P2545, DOI 10.1001/jama.289.19.2545 | - |
hcfmusp.relation.reference | Middleton H, 2005, BRIT MED J, V330, P267, DOI 10.1136/bmj.330.7486.267 | - |
hcfmusp.relation.reference | Murray EA, 2011, BIOL PSYCHIAT, V69, pE43, DOI 10.1016/j.biopsych.2010.09.041 | - |
hcfmusp.relation.reference | Nemeroff CB, 2007, J CLIN PSYCHIAT, V68, P17 | - |
hcfmusp.relation.reference | Nitsche MA, 2009, EXP NEUROL, V219, P14, DOI 10.1016/j.expneurol.2009.03.038 | - |
hcfmusp.relation.reference | Nitsche MA, 2009, BIOL PSYCHIAT, V66, P503, DOI 10.1016/j.biopsych.2009.03.022 | - |
hcfmusp.relation.reference | Nitsche MA, 2003, SUPPL CLIN NEUROPHYS, V56, P255 | - |
hcfmusp.relation.reference | Nitsche MA, 2004, EUR J NEUROSCI, V19, P2720, DOI 10.1111/j.1460-9568.2004.03398.x | - |
hcfmusp.relation.reference | O'Reardon JP, 2007, DEPRESS ANXIETY, V24, P537, DOI 10.1002/da.20261 | - |
hcfmusp.relation.reference | Palm U, 2012, BRAIN STIMUL, V5, P242, DOI 10.1016/j.brs.2011.08.005 | - |
hcfmusp.relation.reference | PEET M, 1994, BRIT J PSYCHIAT, V164, P549, DOI 10.1192/bjp.164.4.549 | - |
hcfmusp.relation.reference | Petersen T, 2005, J CLIN PSYCHOPHARM, V25, P336, DOI 10.1097/01.jcp.0000169036.40755.16 | - |
hcfmusp.relation.reference | Poreisz C, 2007, BRAIN RES BULL, V72, P208, DOI 10.1016/j.brainresbull.2007.01.004 | - |
hcfmusp.relation.reference | Priori A, 2009, BRAIN STIMUL, V2, P241, DOI 10.1016/j.brs.2009.02.004 | - |
hcfmusp.relation.reference | Quide Y, 2012, NEUROSCI BIOBEHAV R, V36, P626, DOI 10.1016/j.neubiorev.2011.09.004 | - |
hcfmusp.relation.reference | Rigonatti SP, 2008, EUR PSYCHIAT, V23, P74, DOI 10.1016/j.eurpsy.2007.09.006 | - |
hcfmusp.relation.reference | Rossini D, 2005, J CLIN PSYCHIAT, V66, P1569 | - |
hcfmusp.relation.reference | Rumi DO, 2005, BIOL PSYCHIAT, V57, P162, DOI 10.1016/j.biopsych.2004.10.029 | - |
hcfmusp.relation.reference | Sackeim HA, 2009, ARCH GEN PSYCHIAT, V66, P729, DOI 10.1001/archgenpsychiatry.2009.75 | - |
hcfmusp.relation.reference | Schutter DJLG, 2009, PSYCHOL MED, V39, P65, DOI 10.1017/S0033291708003462 | - |
hcfmusp.relation.reference | Simpson KN, 2009, ADV THER, V26, P346, DOI 10.1007/s12325-009-0013-x | - |
hcfmusp.relation.reference | Stagg CJ, 2011, NEUROSCIENTIST, V17, P37, DOI 10.1177/1073858410386614 | - |
hcfmusp.relation.reference | Tadini L, 2011, J ECT, V27, P134, DOI 10.1097/YCT.0b013e3181e631a8 | - |
hcfmusp.relation.reference | Trivedi MH, 2006, NEW ENGL J MED, V354, P1243, DOI 10.1056/NEJMoa052964 | - |
hcfmusp.relation.reference | Turner EH, 2008, NEW ENGL J MED, V358, P252, DOI 10.1056/NEJMsa065779 | - |
hcfmusp.relation.reference | Xia GH, 2008, INT J NEUROPSYCHOPH, V11, P119, DOI 10.1017/S1461145707007699 | - |
hcfmusp.relation.reference | Ziemann U, 2004, CLIN NEUROPHYSIOL, V115, P1717, DOI 10.1016/j.clinph.2004.03.006 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.citation.scopus | 470 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
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