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Title: A Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury
Authors: ALMEIDA, Danilo Candido deBASSI, Enio JoseAZEVEDO, HatylasANDERSON, LeticiaORIGASSA, Clarice Silvia TaemiCENEDEZE, Marcos AntonioANDRADE-OLIVEIRA, Vinicius deFELIZARDO, Raphael Jose FerreiraSILVA, Reinaldo Correia daHIYANE, Meire IoshieSEMEDO, PatriciaREIS, Marlene Antonia dosMOREIRA-FILHO, Carlos AlbertoVERJOVSKI-ALMEIDA, SergioPACHECO-SILVA, AlvaroCAMARA, Niels Olsen Saraiva
Citation: FRONTIERS IN IMMUNOLOGY, v.7, article ID 645, 18p, 2017
Abstract: Mesenchymal stromal cells (MSCs) orchestrate tissue repair by releasing cell-derived microvesicles (MVs), which, presumably by small RNA species, modulate global gene expression. The knowledge of miRNA/mRNA signatures linked to a reparative status may elucidate some of the molecular events associated with MSC protection. Here, we used a model of cisplatin-induced kidney injury (acute kidney injury) to assess how MSCs or MVs could restore tissue function. MSCs and MVs presented similar protective effects, which were evidenced in vivo and in vitro by modulating apoptosis, inflammation, oxidative stress, and a set of prosurvival molecules. In addition, we observed that miRNAs (i.e., miR-880, miR-141, miR-377, and miR-21) were modulated, thereby showing active participation on regenerative process. Subsequently, we identified that MSC regulates a particular miRNA subset which mRNA targets are associated with Wnt/TGF-beta fibrosis, and epithelial-mesenchymal transition signaling pathways. Our results suggest that MSCs release MVs that transcriptionally reprogram injured cells, thereby modulating a specific miRNA-mRNA network.
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Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

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