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Title: | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer |
Authors: | LESSEUR, Corina; DIERGAARDE, Brenda; OLSHAN, Andrew F.; WUNSCH-FILHO, Victor; NESS, Andrew R.; LIU, Geoffrey; LACKO, Martin; ELUF-NETO, Jose; FRANCESCHI, Silvia; LAGIOU, Pagona; MACFARLANE, Gary J.; RICHIARDI, Lorenzo; BOCCIA, Stefania; POLESEL, Jerry; KJAERHEIM, Kristina; ZARIDZE, David; JOHANSON, Mattias; MENEZES, Ana M.; CURADO, Maria Paula; ROBINSON, Max; AHRENS, Wolfgang; CANOVA, Cristina; ZNAOR, Ariana; CASTELLSAGUE, Xavier; CONWAY, David I.; HOLCATOVA, Ivana; MATES, Dana; VIDENSKY, Marta; HEALY, Claire M.; SZESZENIA-DBROWSKA, Neonila; FABIANOVA, Eleonora; LISSOWSKA, Jolanta; GRANDIS, Jennifer R.; WEISSLER, Mark C.; TAJARA, Eloiza H.; NUNES, Fabio D.; CARVALHO, Marcos B. de; THOMAS, Steve; HUNG, Rayjean J.; PETERS, Wilbert H. M.; HERRERO, Rolando; CADONI, Gabriella; BUENO-DE-MESQUITA, H. Bas; STEFFEN, Annika; AGUDO, Antonio; SHANGINA, Oxana; XIAO, Xiangjun; GABORIEAU, Valerie; CHABRIER, Amelie; ANANTHARAMAN, Devasena; BOFFETTA, Paolo; AMOS, Christopher I.; MCKAY, James D.; BRENNAN, Paul |
Citation: | NATURE GENETICS, v.48, n.12, p.1544-1550, 2016 |
Abstract: | We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/38 Artigos e Materiais de Revistas Científicas - ODS/03 |
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