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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorTAVARES, Aline Cristina-
dc.contributor.authorBOCCHI, Edimar Alcides-
dc.contributor.authorGUIMARAES, Guilherme Veiga-
dc.identifier.citationCLINICS, v.67, n.3, p.273-278, 2012-
dc.description.abstractAlthough it is known that obesity, diabetes, and Kawasaki's disease play important roles in systemic inflammation and in the development of both endothelial dysfunction and cardiomyopathy, there is a lack of data regarding the endothelial function of pre-pubertal children suffering from cardiomyopathy. In this study, we performed a systematic review of the literature on pre-pubertal children at risk of developing cardiomyopathy to assess the endothelial function of pre-pubertal children at risk of developing cardiomyopathy. We searched the published literature indexed in PubMed, Bireme and SciELO using the keywords 'endothelial', 'children', 'pediatric' and 'infant' and then compiled a systematic review. The end points were age, the pubertal stage, sex differences, the method used for the endothelial evaluation and the endothelial values themselves. No studies on children with cardiomyopathy were found. Only 11 papers were selected for our complete analysis, where these included reports on the flow-mediated percentage dilatation, the values of which were 9.80 +/- 1.80, 5.90 +/- 1.29, 4.50 +/- 0.70, and 7.10 +/- 1.27 for healthy, obese, diabetic and pre-pubertal children with Kawasaki's disease, respectively. There was no significant difference in the dilatation, independent of the endothelium, either among the groups or between the genders for both of the measurements in children; similar results have been found in adolescents and adults. The endothelial function in cardiomyopathic children remains unclear because of the lack of data; nevertheless, the known dysfunctions in children with obesity, type 1 diabetes and Kawasaki's disease may influence the severity of the cardiovascular symptoms, the prognosis, and the mortality rate. The results of this study encourage future research into the consequences of endothelial dysfunction in pre-pubertal children.-
dc.description.sponsorshipConselho Nacional de Pesquisa (CNPq) [304733/2008-3]-
dc.subjectEndothelial Function-
dc.subject.otherc-reactive protein-
dc.subject.otherintima-media thickness-
dc.subject.otherarterial stiffness-
dc.subject.otherobese children-
dc.subject.otherfamilial hypercholesterolemia-
dc.subject.otherultrasound assessment-
dc.titleEndothelial function in pre-pubertal children at risk of developing cardiomyopathy: a new frontier-
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO-
dc.subject.wosMedicine, General & Internal-
hcfmusp.publisher.citySAO PAULO-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

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