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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMARIA, Durvanei Augusto-
dc.contributor.authorSOUZA, Jean Gabriel de-
dc.contributor.authorMORAIS, Katia L. P.-
dc.contributor.authorBERRA, Carolina Maria-
dc.contributor.authorZAMPOLLI, Hamilton de Campos-
dc.contributor.authorDEMASI, Marilene-
dc.contributor.authorSIMONS, Simone Michaela-
dc.contributor.authorSAITO, Renata de Freitas-
dc.contributor.authorCHAMMAS, Roger-
dc.contributor.authorCHUDZINSKI-TAVASSI, Ana Marisa-
dc.date.accessioned2013-09-23T16:37:32Z-
dc.date.available2013-09-23T16:37:32Z-
dc.date.issued2013-
dc.identifier.citationINVESTIGATIONAL NEW DRUGS, v.31, n.3, p.493-505, 2013-
dc.identifier.issn0167-6997-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1881-
dc.description.abstractIn cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2 family protein regulation, the impairment of mitochondrial functions, and ROS production. Notwithstanding, several drugs operate through proteasome inhibition, which, by inducing the accumulation and aggregation of misfolded or unfolded proteins, can lead to endoplasmic reticulum (ER) stress. Accordingly, it was shown that Amblyomin-X, a Kunitz-type inhibitor identified in the transcriptome of the Amblyomma cajennense tick by ESTs sequence analysis of a cDNA library, obtained in recombinant protein form, induces apoptosis in murine renal adenocarcinoma (RENCA) cells by: inducing imbalance between pro- and anti-apoptotic Bcl-2 family proteins, dysfunction/mitochondrial damage, production of reactive oxygen species (ROS), caspase cascade activation, and proteasome inhibition, all ER-stress inductive. Moreover, there was no manifest action on normal mouse-fibroblast cells (NHI3T3), suggesting an Amblyomin-X tumor-cell selectivity. Taken together, these evidences indicate that Amblyomin-X could be a promising candidate for cancer therapy.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2010/52669-3, CAT/CEPID - 1998/14307-9]-
dc.description.sponsorshipUniao Quimica Farmaceutica Nacional-
dc.description.sponsorshipConselho Nacional de Pesquisa e Desenvolvimento (CNPq, INCTTox)-
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)-
dc.language.isoeng-
dc.publisherSPRINGER-
dc.relation.ispartofInvestigational New Drugs-
dc.rightsrestrictedAccess-
dc.subjectApoptosis-
dc.subjectBcl-2 family protein-
dc.subjectCaspase-
dc.subjectReactive oxygen species-
dc.subjectProteasome-
dc.subject.otherendoplasmic-reticulum stress-
dc.subject.otherrenal-cell-carcinoma-
dc.subject.otherbcl-2 family proteins-
dc.subject.othercancer-cells-
dc.subject.othermembrane permeabilization-
dc.subject.othermediated apoptosis-
dc.subject.otheroxidative stress-
dc.subject.otherprostate-cancer-
dc.subject.otherquality-control-
dc.subject.otheramblyomin-x-
dc.titleA novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production-
dc.typearticle-
dc.rights.holderCopyright SPRINGER-
dc.identifier.doi10.1007/s10637-012-9871-1-
dc.identifier.pmid22975862-
dc.subject.wosOncology-
dc.subject.wosPharmacology & Pharmacy-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalMARIA, Durvanei Augusto:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalSOUZA, Jean Gabriel de:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil-
hcfmusp.author.externalMORAIS, Katia L. P.:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil-
hcfmusp.author.externalBERRA, Carolina Maria:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalZAMPOLLI, Hamilton de Campos:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil; Inst Butantan, Programa Posgrad Interunidades Biotecnol, USP, IPT, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalDEMASI, Marilene:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalSIMONS, Simone Michaela:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalCHUDZINSKI-TAVASSI, Ana Marisa:Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil; Inst Butantan, Programa Posgrad Interunidades Biotecnol, USP, IPT, BR-05503900 Sao Paulo, Brazil-
hcfmusp.description.beginpage493-
hcfmusp.description.endpage505-
hcfmusp.description.issue3-
hcfmusp.description.volume31-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84879077470-
hcfmusp.origem.idWOS:000318657000001-
hcfmusp.publisher.cityDORDRECHT-
hcfmusp.publisher.countryNETHERLANDS-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipINCTs-
hcfmusp.citation.scopus32-
hcfmusp.scopus.lastupdate2022-06-17-
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