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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFERRAROTTO, Renata-
dc.contributor.authorHOFF, Paulo M.-
dc.identifier.citationCLINICAL COLORECTAL CANCER, v.12, n.1, p.1-7, 2013-
dc.description.abstractAngiogenesis is essential to cancer development and progression, and its inhibition has been shown to benefit patients with several different malignancies. A considerable number of antiangiogenic compounds have been evaluated for the treatment of colorectal cancer; but only bevacizumab and aflibercept were able to demonstrate a survival benefit in phase III trials. In this review, we discuss important aspects of the interrelationship between tumor cells and the microenvironment leading to tumor progression, with a focus on angiogenesis. Clinical data on antiangiogenic therapies for colorectal cancer in the metastatic and adjuvant settings, as well as the potential use of antiangiogenics beyond tumor progression are analyzed. The need to identify surrogate biomarkers towards a more personalized approach in oncology is emphasized as this is becoming increasingly important in drug development. Clinical Colorectal Cancer, Vol. 12, No. 1, 1-7 (C) 2013 Elsevier Inc. All rights reserved.-
dc.publisherCIG MEDIA GROUP, LP-
dc.relation.ispartofClinical Colorectal Cancer-
dc.subjectMetastatic colorectal cancer-
dc.subject.otherendothelial growth-factor-
dc.subject.otheradvanced gastrointestinal malignancies-
dc.subject.otheroxaliplatin-based chemotherapy-
dc.subject.otherphase-ii trial-
dc.subject.otherpredictive markers-
dc.subject.other1st-line treatment-
dc.subject.otherplus bevacizumab-
dc.subject.otherptk787/zk 222584-
dc.subject.otherhuman tumor-
dc.titleAntiangiogehic Drugs for Colorectal Cancer: Exploring New Possibilities-
dc.rights.holderCopyright CIG MEDIA GROUP, LP-
dc.type.versionpublishedVersion-, Renata:Hosp Sirio Libanes, Dept Oncol, BR-01308050 Sao Paulo, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MDR
Departamento de Radiologia - FM/MDR

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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