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https://observatorio.fm.usp.br/handle/OPI/1902
Título: | Expression of PAR-4 and PHLDA1 is prognostic for overall and disease-free survival in oral squamous cell carcinomas |
Autor(es): | COUTINHO-CAMILLO, Claudia Malheiros; LOURENCO, Silvia Vanessa; NONOGAKI, Suely; VARTANIAN, Jose Guilherme; NAGAI, Maria Aparecida; KOWALSKI, Luiz Paulo; SOARES, Fernando Augusto |
Parte de: | VIRCHOWS ARCHIV, v.463, n.1, p.31-39, 2013 |
Resumo: | PAR-4 is a tumor suppressor protein with a pro-apoptotic function and down-regulation of PAR-4 is seen in a variety of tumors. PHLDA1 gene overexpression has been shown to reduce cell proliferation and induce cell death in a variety of cell types. In this study, 229 cases of oral squamous cell carcinoma (OSCC), arranged in a tissue microarray, were analyzed by immunohistochemistry. PAR-4 expression was predominantly moderate to strong and expression of PHLDA1 was predominantly negative or weak. Cytoplasmic expression of PAR-4 was associated with advanced clinical stage. Expression of PHLDA1 was associated with advanced clinical stage of the tumour. Five-year overall and disease-free survival rates differed significantly between cases that did and cases that did not express PHLDA1, and by multivariate analysis, expression of PHLDA1 and PAR-4 were independent prognostic factors in OSCC patients. Expression of PAR-4 and PHLDA1 is altered in OSCC and might be a valuable prognostic indicator for this disease. |
Aparece nas coleções: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
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