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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorKAHWAGE, Paola Pinheiro-
dc.contributor.authorFERRIANI, Mariana Paes Leme-
dc.contributor.authorFURTADO, Joao M.-
dc.contributor.authorCARVALHO, Luciana Martins de-
dc.contributor.authorPILEGGI, Gecilmara Salviato-
dc.contributor.authorGOMES, Francisco Hugo Rodrigues-
dc.contributor.authorTERRERI, Maria Teresa-
dc.contributor.authorMAGALHAES, Claudia Saad-
dc.contributor.authorPEREIRA, Rosa Maria Rodrigues-
dc.contributor.authorSACCHETTI, Silvana Brasilia-
dc.contributor.authorMARINI, Roberto-
dc.contributor.authorBONFA, Eloisa-
dc.contributor.authorSILVA, Clovis Artur-
dc.contributor.authorFERRIANI, Virginia Paes Leme-
dc.identifier.citationCLINICAL RHEUMATOLOGY, v.36, n.3, p.547-553, 2017-
dc.description.abstractThe aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator meeting was held and all participants received database training. Uveitis was diagnosed through clinical assessment by the uveitis expert ophthalmologist of each center. Patients with and without uveitis were assessed for lupus clinical/laboratory features and treatments. Uveitis was observed in 7/852 cSLE patients (0.8%). Two of them had ocular complications: cataract and irreversible blindness in one patient and retinal ischemia with subsequent neovascularization and unilateral blindness in another. Uveitis was identified within the first 6 months of cSLE diagnosis in 6/7 patients (86%). Comparison of a subgroup of cSLE patients with (n = 7) and without uveitis (n = 73) and similar length of disease duration showed that patients with uveitis had increased SLEDAI-2K score (19 vs. 6; p < 0.01). In addition, fever (71 vs. 12%; p < 0.01), lymphadenopathy (29 vs. 1.4%; p = 0.02), arthritis (43 vs. 7%; p = 0.02), and use of intravenous methylprednisolone (71 vs. 22%; p = 0.01) were higher in cSLE patients with uveitis, as compared to those without this manifestation, respectively. Presence of fever was significantly associated with uveitis, independently of SLEDAI scores or use of intravenous methylprednisolone pulses, as shown by adjusted regression analysis (adjusted prevalence ratio 35.7, 95% CI 2.4-519.6; p < 0.01). Uveitis was a rare and initial manifestation of active cSLE patients. Early recognition is essential due to the possibility of irreversible blindness.-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [309520/2012-6, 303752/2015-7, 301479/2015-1, 301805/2013-0, 305068/2014-8, 303422/2015-7]-
dc.description.sponsorshipFederico Foundation-
dc.description.sponsorshipNucleo de Apoio a Pesquisa ""Saude da Crianca e do Adolescente"" da USP (NAP-CriAd)-
dc.relation.ispartofClinical Rheumatology-
dc.subjectChildhood-onset systemic lupus erythematosus-
dc.subjectCohort study-
dc.subject.otherocular manifestations-
dc.subject.otherretinal vasculitis-
dc.subject.otherpediatric uveitis-
dc.titleUveitis in childhood-onset systemic lupus erythematosus patients: a multicenter survey-
dc.rights.holderCopyright SPRINGER LONDON LTD-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Paola Pinheiro:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Pediat, Av Bandeirantes 3900 Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil-, Joao M.:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ribeirao Preto, Brazil-, Luciana Martins de:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Pediat, Av Bandeirantes 3900 Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil-, Gecilmara Salviato:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Pediat, Av Bandeirantes 3900 Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil-, Francisco Hugo Rodrigues:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Pediat, Av Bandeirantes 3900 Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil-, Maria Teresa:Univ Fed So Paulo UNIFESP, Pediat Rheumatol Unit, Sao Paulo, Brazil-, Claudia Saad:Univ Estadual Sao Paulo FMB UNESP, Pediat Rheumatol Unit, Fac Med Botucatu, Sao Paulo, Brazil-, Silvana Brasilia:Irmandade Santa Casa Misericordia Sao Paulo, Sao Paulo, Brazil-, Roberto:Univ Campinas FCM UNICAMP, Rheumatol Unit, Fac Ciencias Med, Sao Paulo, Brazil-, Virginia Paes Leme:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Pediat, Av Bandeirantes 3900 Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

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