Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/2047
Title: | Androgen receptor gene polymorphism and polycystic ovary syndrome |
Authors: | LIN, Lawrence H.; BARACAT, Maria C. P.; MACIEL, Gustavo A. R.; SOARES JR., Jose M.; BARACAT, Edmund C. |
Citation: | INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, v.120, n.2, p.115-118, 2013 |
Abstract: | Background: Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and hyperandrogenism. Its etiopathology is not well understood but genetic factors seem to have a role. Polymorphism of the androgen receptor (AR) gene has been associated with different androgen pattern diseases. Objective: To review the association between AR gene polymorphism and PCOS. Search strategy: A systematic review was performed via PUBMED, EMBASE, and LILACS (up to May 31, 2011). Selection criteria: Studies assessing the presence of the (CAG)(n) polymorphism of the AR gene in at least 2 comparison groups (PCOS and control). Studies that did not contain adequate information were excluded. Data collection and analysis: Study characteristics and results were analyzed. Meta-analysis could not be performed because only 2 articles provided odds ratios. Main results: Ten studies met the inclusion criteria. Three studies reported a correlation between the polymorphism and PCOS; 2 studies linked the disorder to shorter repeats, whereas the other associated it with longer repeats. Conclusion: Polymorphism of the AR gene seems to be a promising biomarker for PCOS because shorter repeats may be linked to the disorder. However, further studies are needed to understand the association fully. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/58 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_LIN_Androgen_receptor_gene_polymorphism_and_polycystic_ovary_syndrome_2013.PDF Restricted Access | publishedVersion (English) | 122.31 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.