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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorRUANO, Rodrigo-
dc.contributor.authorTAKASHI, Eduardo-
dc.contributor.authorSILVA, Marcos Marques da-
dc.contributor.authorHAERI, Sina-
dc.contributor.authorTANNURI, Uenis-
dc.contributor.authorZUGAIB, Marcelo-
dc.identifier.citationJOURNAL OF ULTRASOUND IN MEDICINE, v.32, n.3, p.413-417, 2013-
dc.description.abstractObjectives-To estimate the accuracy of the quantitative lung index and contralateral lung area for prediction of the neonatal outcome in isolated congenital diaphragmatic hernia in comparison to other available prediction models. Methods-Between January 2004 and December 2010, 108 fetuses with isolated (82 left-sided and 26 right-sided) congenital diaphragmatic hernia were prospectively evaluated. The quantitative lung index and observed-to-expected contralateral lung area were measured and compared to the neonatal survival rate and severe postnatal pulmonary arterial hypertension, along with the lung-to-head ratio, observed-to-expected lung-to-head ratio, and observed-to-expected total lung volume. Results-Overall neonatal mortality was 64.8% (70 of 108). Severe pulmonary arterial hypertension was diagnosed in 68 (63.0%) of the cases, which was associated with neonatal death (P < .001). Both the quantitative lung index and observed-to-expected contralateral lung area were significantly associated with neonatal survival and pulmonary arterial hypertension (P < .001), with accuracy to predict survival of 70.9% and 70.0%, respectively, and accuracy to predict hypertension of 78.7% and 72.0%; however, they were both less accurate than the observed-to-expected total lung volume (83.3% and 86.1%; P < .01). The lung-to-head ratio (73.1% and 78.7%) and observed-to-expected lung-to-head ratio (75.9% and 72.2%; P > .05) had similar accuracy as the quantitative lung index and observed-to-expected contralateral lung area. Conclusions-The observed-to-expected total lung volume is the most accurate predictor of the neonatal outcome in cases of isolated congenital diaphragmatic hernia. Both the quantitative lung index and observed-to-expected contralateral lung area, albeit reasonably accurate, do not produce the same level of accuracy and render similar results as the lung-to-head ratio and observed-to-expected lung-to-head ratio.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)-
dc.relation.ispartofJournal of Ultrasound in Medicine-
dc.subjectcongenital diaphragmatic hernia-
dc.subjectneonatal outcome-
dc.subjectpulmonary arterial hypertension-
dc.subjectpulmonary hypoplasia-
dc.subject.otheroperating characteristic curves-
dc.subject.otherendoscopic tracheal occlusion-
dc.subject.otherextracorporeal membrane-oxygenation-
dc.subject.other3-dimensional ultrasonography-
dc.titleQuantitative Lung Index, Contra lateral Lung Area, or Lung-to-Head Ratio to Predict the Neonatal Outcome in Isolated Congenital Diaphragmatic Hernia?-
dc.rights.holderCopyright AMER INST ULTRASOUND MEDICINE-
dc.subject.wosRadiology, Nuclear Medicine & Medical Imaging-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Eduardo:Univ Sao Paulo, Fac Med, Dept Obstet & Gynecol, BR-05403900 Sao Paulo, Brazil-, Sina:Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA; Texas Childrens Hosp, Houston, TX 77030 USA-
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/30
LIM/30 - Laboratório de Investigação em Cirurgia Pediátrica

Artigos e Materiais de Revistas Científicas - LIM/57
LIM/57 - Laboratório de Fisiologia Obstétrica

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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