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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMACIEL, Lea Maria Zanini-
dc.contributor.authorKIMURA, Edna Teruko-
dc.contributor.authorNOGUEIRA, Celia Regina-
dc.contributor.authorMAZETO, Glaucia M. F. S.-
dc.contributor.authorMAGALHAES, Patricia Kuenzle Ribeiro-
dc.contributor.authorNASCIMENTO, Marilza Leal-
dc.contributor.authorNESI-FRANCA, Suzana-
dc.contributor.authorVIEIRA, Sandra E.-
dc.date.accessioned2013-09-23T16:43:09Z-
dc.date.available2013-09-23T16:43:09Z-
dc.date.issued2013-
dc.identifier.citationARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, v.57, n.3, Special Issue, p.184-192, 2013-
dc.identifier.issn0004-2730-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2096-
dc.description.abstractCongenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum.-
dc.description.abstractO hipotireoidismo congênito (HC) é o distúrbio endócrino congênito mais frequente, com incidência variando de 1:2.000 a 1:4.000 crianças nascidas vivas e uma das principais causas de retardo mental que pode ser prevenida. Os Programas de Triagem Neonatal para a doença permitem a identificação precoce dos afetados e seu tratamento de modo a evitar as complicações da falta do hormônio. A maioria dos casos de hipotireoidismo congênito é decorrente de disgenesias tireoidianas (85%), entre elas a ectopia, hipoplasia ou agenesia tireoidianas, e os demais resultam de defeitos de síntese hormonal. As crianças afetadas (> 95%) geralmente não apresentam sintomas sugestivos da doença ao nascimento. Os sintomas e sinais mais comuns são: icterícia neonatal prolongada, choro rouco, letargia, movimentos lentos, constipação, macroglossia, hérnia umbilical, fontanelas amplas, hipotonia e pele seca. Várias estratégias são utilizadas para a triagem do HC. No Brasil, esta é obrigatória por lei e geralmente é feita com a dosagem de TSH em sangue seco coletado do calcanhar. A idade recomendada para sua realização é após as 48 horas de vida até o quarto dia. A confirmação diagnóstica é obrigatória com as dosagens de TSH e T4 livre ou T4 total.-
dc.language.isopor-
dc.language.isoeng-
dc.publisherSBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA-
dc.relation.ispartofArquivos Brasileiros de Endocrinologia e Metabologia-
dc.rightsopenAccess-
dc.subjectCongenital hypothyroidism-
dc.subjectneonatal screening-
dc.subjectHipotireoidismo congênito-
dc.subjectTriagem neonatal-
dc.subject.otherregional-screening-program-
dc.subject.otherunited-states-
dc.subject.otherrisk-factors-
dc.subject.othertransient hypothyroidism-
dc.subject.otherbirth-weight-
dc.subject.otherhormone-
dc.subject.otherthyrotropin-
dc.subject.otherpopulation-
dc.subject.otherthyroxine-
dc.subject.othermutations-
dc.titleHipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia-
dc.title.alternativeCongenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism-
dc.typearticle-
dc.rights.holderCopyright SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA-
dc.identifier.doi10.1590/S0004-27302013000300004-
dc.identifier.pmid23681264-
dc.subject.wosEndocrinology & Metabolism-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalMACIEL, Lea Maria Zanini:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Div Endocrinol & Metabol, Ribeirao Preto, SP, Brazil-
hcfmusp.author.externalKIMURA, Edna Teruko:Univ Sao Paulo, Inst Ciencias Biomed, BR-09500900 Sao Paulo, Brazil-
hcfmusp.author.externalNOGUEIRA, Celia Regina:Univ Estadual Sao Paulo Unesp, Fac Med Botucatu, Dept Clin Med, Div Endocrinol & Metabol, Botucatu, SP, Brazil-
hcfmusp.author.externalMAZETO, Glaucia M. F. S.:Univ Estadual Sao Paulo Unesp, Fac Med Botucatu, Dept Clin Med, Div Endocrinol & Metabol, Botucatu, SP, Brazil-
hcfmusp.author.externalMAGALHAES, Patricia Kuenzle Ribeiro:Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Div Endocrinol & Metabol, Ribeirao Preto, SP, Brazil-
hcfmusp.author.externalNASCIMENTO, Marilza Leal:Univ Fed Santa Catarina, Florianopolis, SC, Brazil-
hcfmusp.author.externalNESI-FRANCA, Suzana:Univ Fed Parana UFPR, Dept Pediat, Unidade Endocrinol Pediat, Curitiba, Parana, Brazil-
hcfmusp.description.beginpage184-
hcfmusp.description.endpage192-
hcfmusp.description.issue3-
hcfmusp.description.issueSpecial Issue-
hcfmusp.description.volume57-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84878066701-
hcfmusp.origem.idWOS:000319993400004-
hcfmusp.origem.idSCIELO:S0004-27302013000300004-
hcfmusp.publisher.cityRIO DE JANEIRO, RJ-
hcfmusp.publisher.countryBRAZIL-
hcfmusp.relation.referenceAlberti L, 2002, J CLIN ENDOCR METAB, V87, P2549, DOI 10.1210/jc.87.6.2549-
hcfmusp.relation.referenceALM J, 1984, BRIT MED J, V289, P1171-
hcfmusp.relation.referenceAl Taji E, 2007, EUR J ENDOCRINOL, V156, P521, DOI 10.1530/EJE-06-0709-
hcfmusp.relation.referenceAzar-Kolakez A, 2013, J CLIN ENDOCR METAB, V98, P785, DOI 10.1210/jc.2012-2731-
hcfmusp.relation.referenceBoelaert K, 2012, CLIN ENDOCRINOL OXF, DOI [10.1111/cen.12127, DOI 10.1111/CEN.12127.[]-
hcfmusp.relation.referenceCastanet M, 2002, HUM MOL GENET, V11, P2051, DOI 10.1093/hmg/11.17.2051-
hcfmusp.relation.referenceCorbetta C, 2009, CLIN ENDOCRINOL, V71, P739, DOI 10.1111/j.1365-2265.2009.03568.x-
hcfmusp.relation.referenceBongers-Schokking JJ, 2000, J PEDIATR, V136, P292, DOI 10.1067/mpd.2000.103351-
hcfmusp.relation.referenceDoyle DA, 2004, J PEDIATR, V145, P190, DOI 10.1016/j.jpeds.2004.04.011-
hcfmusp.relation.referenceDUSSAULT JH, 1983, J CLIN ENDOCR METAB, V56, P849-
hcfmusp.relation.referenceElmlinger MW, 2001, CLIN CHEM LAB MED, V39, P973, DOI 10.1515/CCLM.2001.158-
hcfmusp.relation.referenceFriesema ECH, 2004, LANCET, V364, P1435, DOI 10.1016/S0140-6736(04)17226-7-
hcfmusp.relation.referenceGRANT DB, 1992, ARCH DIS CHILD, V67, P87-
hcfmusp.relation.referenceHANNA CE, 1986, J PEDIATR, V109, P959, DOI 10.1016/S0022-3476(86)80276-1-
hcfmusp.relation.referenceHarris KB, 2007, MOL GENET METAB, V91, P268, DOI 10.1016/j.ymgme.2007.03.012-
hcfmusp.relation.referenceHertzberg V, 2010, PEDIATRICS, V125, pS48, DOI 10.1542/peds.2009-1975E-
hcfmusp.relation.referenceHuo KM, 2011, ENDOCR J, V58, P355-
hcfmusp.relation.referenceKarakoc-Aydiner E, 2012, EUR J ENDOCRINOL, V166, P43, DOI 10.1530/EJE-11-0140-
hcfmusp.relation.referenceKaye CI, 2006, PEDIATRICS, V118, P1304, DOI 10.1542/peds.2006-1782-
hcfmusp.relation.referenceKorzeniewski SJ, 2012, PEDIATRICS, V130, pE1252, DOI 10.1542/peds.2011-3340-
hcfmusp.relation.referenceKorzeniewski SJ, 2013, J PEDIATR-US, V162, P177, DOI 10.1016/j.jpeds.2012.06.050-
hcfmusp.relation.referenceKumar J, 2009, J PEDIATR, V154, P263, DOI 10.1016/j.jpeds.2008.08.023-
hcfmusp.relation.referenceKwon C, 2000, ARCH PEDIAT ADOL MED, V154, P714-
hcfmusp.relation.referenceLAFRANCHI SH, 1979, PEDIATRICS, V63, P180-
hcfmusp.relation.referenceLaFranchi SH, 2007, J PEDIATR ENDOCR MET, V20, P559-
hcfmusp.relation.referenceLaFranchi SH, 2011, CLIN ENDOCRINOL META, V96, P2959-
hcfmusp.relation.referenceLarson C, 2003, J PEDIATR, V143, P587, DOI 10.1067/S0022-3476(03)00332-9-
hcfmusp.relation.referenceLeger J, 2011, J CLIN ENDOCR METAB, V96, P1771, DOI 10.1210/jc.2010-2315-
hcfmusp.relation.referenceMagalhaes PKR, 2009, CAD SAUDE PUBLICA, V25, P445, DOI 10.1590/S0102-311X2009000200023-
hcfmusp.relation.referenceNascimento ML, 2012, ARQ BRAS ENDOCRINOL, V56, P627, DOI 10.1590/S0004-27302012000900005-
hcfmusp.relation.referenceOhnishi H, 2003, J CLIN ENDOCR METAB, V88, P5145, DOI 10.1210/jc.2003-030743-
hcfmusp.relation.referenceOlivieri A, 2002, J CLIN ENDOCR METAB, V87, P557, DOI 10.1210/jc.87.2.557-
hcfmusp.relation.referenceOlney RS, 2010, PEDIATRICS, V125, pS31, DOI 10.1542/peds.2009-1975C-
hcfmusp.relation.referencePark SM, 2005, J MED GENET, V42, P379, DOI 10.1136/jmg.2004.024158-
hcfmusp.relation.referenceParks JS, 2010, PEDIATRICS, V125, pS54, DOI 10.1542/peds.2009-1975F-
hcfmusp.relation.referencePersani L, 2012, J CLIN ENDOCR METAB, V97, P3068, DOI 10.1210/jc.2012-1616-
hcfmusp.relation.referencePHAROAH POD, 1971, LANCET, V1, P308-
hcfmusp.relation.referencePHAROAH POD, 1992, ARCH DIS CHILD, V67, P1073-
hcfmusp.relation.referenceRamos HE, 2008, ARQ BRAS ENDOCRINOL, V52, P1403, DOI 10.1590/S0004-27302008000900003-
hcfmusp.relation.referenceRamos JCRR, 2012, ARQ BRAS ENDOCRINOL, V56, P201, DOI 10.1590/S0004-27302012000300009-
hcfmusp.relation.referenceREFETOFF S, 1993, ENDOCR REV, V14, P348, DOI 10.1210/er.14.3.348-
hcfmusp.relation.referenceRoberts HE, 1997, AM J MED GENET, V71, P29, DOI 10.1002/(SICI)1096-8628(19970711)71:1<29::AID-AJMG5>3.0.CO;2-L-
hcfmusp.relation.referenceRose SR, 2006, PEDIATRICS, V117, P2290-
hcfmusp.relation.referenceRovet J, 1996, J PEDIATR ENDOCR MET, V9, P63-
hcfmusp.relation.referenceSelva KA, 2002, J PEDIATR, V141, P786, DOI 10.1067/mpd.2002.128887-
hcfmusp.relation.referenceShapira SK, 2010, PEDIATRICS, V125, pS64, DOI 10.1542/peds.2009-1975G-
hcfmusp.relation.referenceSupakul N, 2012, AM J ROENTGENOL, V199, pW360, DOI 10.2214/AJR.11.7905-
hcfmusp.relation.referenceTylek-Lemanska D, 2005, J MED SCREEN, V12, P166, DOI 10.1258/096914105775220697-
hcfmusp.relation.referenceVULSMA T, 1989, NEW ENGL J MED, V321, P13, DOI 10.1056/NEJM198907063210103-
hcfmusp.relation.referenceWaller DK, 2000, TERATOLOGY, V62, P36, DOI 10.1002/1096-9926(200007)62:1<36::AID-TERA8>3.0.CO;2-W-
hcfmusp.relation.referenceZilka LJ, 2008, J CLIN LAB ANAL, V22, P254, DOI 10.1002/jcla.20247-
dc.description.indexMEDLINE-
hcfmusp.citation.scopus18-
hcfmusp.scopus.lastupdate2022-06-17-
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