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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorLEITE, Ana Kober N.-
dc.contributor.authorCAVALHEIRO, Beatriz G.-
dc.contributor.authorKULCSAR, Marco Aurélio-
dc.contributor.authorHOFF, Ana de Oliveira-
dc.contributor.authorBRANDÃO, Lenine G.-
dc.contributor.authorCERNEA, Claudio Roberto-
dc.contributor.authorMATOS, Leandro L.-
dc.identifier.citationARCHIVES OF ENDOCRINOLOGY METABOLISM, v.61, n.3, p.222-227, 2017-
dc.description.abstractABSTRACT Objective The present study describes the clinical and tumor characteristics of patients that died from differentiated thyroid cancer and reports on the cause and circumstances of death in these cases. Subjects and methods Retrospective analysis of all the differentiated thyroid cancer (DTC) related deaths at a single institution over a 5-year period, with a total of 33 patients. Results Most of the patients were female (63.6%), with a mean age at diagnosis of 58.2 years. The most common histologic type was papillary (66.7%) and 30.3% were follicular. The distribution according to the TNM classification was: 15.4% of T1; 7.7% T2; 38.4% T3; 19.2% of T4a and 19.2% of T4b. Forty-four percent of cases were N0; 20% N1a and 36.6% of N1b. Twelve patients were considered non-responsive to radioiodine. Only one of the patients did not have distant metastases. The most common metastatic site was the lung in 69.7%. The majority of deaths were due to pulmonary complications related to lung metastases (17 patients, 51.5%), followed by post-operative complications in 5 cases, neurological disease progression in 3 cases, local invasion and airway obstruction in one patient. Median survival between diagnosis and death was reached in 49 months while between disease progression and death it was at 22 months. Conclusion Mortality from DTC is extremely rare but persists, and the main causes of death derive from distant metastasis, especially respiratory failure due to lung metastasis. Once disease progression is established, median survival was only 22 months.-
dc.publisherSociedade Brasileira de Endocrinologia e Metabologia-
dc.relation.ispartofArchives of Endocrinology and Metabolism-
dc.subjectthyroid cancer-
dc.titleDeaths related to differentiated thyroid cancer: a rare but real event-
dc.rights.holderCopyright Sociedade Brasileira de Endocrinologia e Metabologia-
dc.type.categoryoriginal article-
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Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/28
LIM/28 - Laboratório de Cirurgia Vascular e da Cabeça e Pescoço

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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