https://observatorio.fm.usp.br/handle/OPI/21309
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | NAHAS, Caio Sergio Rizkallah | - |
dc.contributor.author | NAHAS, Sergio Carlos | - |
dc.contributor.author | RIBEIRO-JUNIOR, Ulysses | - |
dc.contributor.author | BUSTAMANTE-LOPEZ, Leonardo | - |
dc.contributor.author | MARQUES, Carlos Frederico Sparapan | - |
dc.contributor.author | PINTO, Rodrigo Ambar | - |
dc.contributor.author | IMPERIALE, Antonio Rocco | - |
dc.contributor.author | COTTI, Guilherme Cutait | - |
dc.contributor.author | NAHAS, William Carlos | - |
dc.contributor.author | CHADE, Daher Cezar | - |
dc.contributor.author | PIATO, Dariane Sampaio | - |
dc.contributor.author | BUSNARDO, Fabio | - |
dc.contributor.author | CECCONELLO, Ivan | - |
dc.date.accessioned | 2017-08-17T19:16:22Z | - |
dc.date.available | 2017-08-17T19:16:22Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | CLINICS, v.72, n.5, p.258-264, 2017 | - |
dc.identifier.issn | 1807-5932 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/21309 | - |
dc.description.abstract | OBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with primary colorectal cancer selected for multivisceral resection were identified from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcomes were obtained from medical records. Estimated local recurrence and overall survival were compared using the log-rank method, and Cox regression analysis was used to determine the independence of the studied parameters. ClinicalTrials.gov: NCT02859155. RESULTS: The median age of the patients was 60 (range 23-86) years, 66.7% were female, 80% of tumors were located in the rectum, 11.4% had stage-IV disease, and 54.3% received neoadjuvant chemoradiotherapy. The organs most frequently resected were ovaries and annexes (37%). Additionally, 30.5% of patients received abdominoperineal resection. Invasion of other organs was confirmed histologically in 53.5% of patients, and R0 resection was obtained in 72% of patients. The overall morbidity rate of patients in this study was 37.1%. Ureter resection and intraoperative blood transfusion were independently associated with an increased number of complications. The 30-day postoperative mortality rate was 1.9%. After 27 (range 5-57) months of follow-up, the mortality and local recurrence rates were 23% and 15%, respectively. Positive margins were associated with a higher recurrence rate. Positive margins, lymph node involvement, stage III/IV disease, and stage IV disease alone were associated with lower overall survival rates. On multivariate analysis, the only factor associated with reduced survival was lymph node involvement. CONCLUSIONS: Multivisceral en bloc resection for primary colorectal cancer can be performed with acceptable rates of morbidity and mortality and may lead to favorable oncological outcomes. | - |
dc.language.iso | eng | - |
dc.publisher | HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.relation.ispartof | Clinics | - |
dc.rights | openAccess | - |
dc.subject | Colorectal Cancer | - |
dc.subject | Survival | - |
dc.subject | Recurrence | - |
dc.subject.other | advanced rectal-cancer | - |
dc.subject.other | colon-cancer | - |
dc.subject.other | t4 tumors | - |
dc.title | Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer | - |
dc.type | article | - |
dc.rights.holder | Copyright HOSPITAL CLINICAS, UNIV SAO PAULO | - |
dc.identifier.doi | 10.6061/clinics/2017(05)01 | - |
dc.identifier.pmid | 28591336 | - |
dc.subject.wos | Medicine, General & Internal | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 258 | - |
hcfmusp.description.endpage | 264 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 72 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-85020483127 | - |
hcfmusp.origem.id | WOS:000403263700001 | - |
hcfmusp.origem.id | SCIELO:S1807-59322017000500258 | - |
hcfmusp.publisher.city | SAO PAULO | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1980-5322 | - |
hcfmusp.citation.scopus | 4 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/35 Artigos e Materiais de Revistas Científicas - LIM/37 Artigos e Materiais de Revistas Científicas - LIM/55 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_NAHAS_Prognostic_factors_affecting_outcomes_in_multivisceral_en_bloc_2017.PDF | publishedVersion (English) | 382.71 kB | Adobe PDF | View/Open |
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