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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTAMASHIRO-DURAN, Jaqueline Hatsuko
dc.contributor.authorSQUARZONI, Paula
dc.contributor.authorDURAN, Fabio Luis de Souza
dc.contributor.authorCURIATI, Pedro Kallas
dc.contributor.authorVALLADA, Homero Pinto
dc.contributor.authorBUCHPIGUEL, Carlos Alberto
dc.contributor.authorLOTUFO, Paulo Andrade
dc.contributor.authorWAJNGARTEN, Mauricio
dc.contributor.authorMENEZES, Paulo Rossi
dc.contributor.authorSCAZUFCA, Marcia
dc.contributor.authorALVES, Tania Correa de Toledo Ferraz
dc.contributor.authorBUSATTO, Geraldo Filho
dc.date.accessioned2013-09-23T16:44:15Z
dc.date.available2013-09-23T16:44:15Z
dc.date.issued2013
dc.identifier.citationAGE, v.35, n.3, p.777-792, 2013
dc.identifier.issn0161-9152
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2160
dc.description.abstractCardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein epsilon 4 (APOE epsilon 4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date. The present FDG-PET study investigated 59 cognitively preserved elderlies divided into three groups according to their cardiovascular risk based on the Framingham 10-year risk Coronary Heart Disease Risk Profile (low-, medium-, and high-risk) to examine whether different levels of CVRF would be associated with reduced CMRgl, involving the same brain regions affected in early stages of AD. Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE epsilon 4 allele as a confounding covariate. Significant cerebral metabolism reductions were detected in the high-risk group when compared to the low-risk group in the left precuneus and posterior cingulate gyrus. This suggests that findings of brain hypometabolism similar to those seen in subjects with AD can be detected in association with the severity of cardiovascular risk in cognitively preserved individuals. Thus, a greater knowledge about how such factors influence brain functioning in healthy subjects over time may provide important insigths for the future development of strategies aimed at delaying or preventing the vascular-related triggering of pathologic brain changes in the AD.
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofAge
dc.rightsrestrictedAccess
dc.subjectAging
dc.subjectAlzheimer's disease
dc.subjectPositron emission tomography
dc.subjectFramingham Heart Study Risk Score
dc.subjectApolipoprotein E
dc.subject.othercerebral-blood-flow
dc.subject.othergender-related differences
dc.subject.othervoxel-based morphometry
dc.subject.otheralzheimers-disease
dc.subject.othervascular dementia
dc.subject.otherstroke risk
dc.subject.otherendothelial dysfunction
dc.subject.otherinverse association
dc.subject.othermemory impairment
dc.subject.otherf-18-fdg pet
dc.titleCardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations
dc.typearticle
dc.rights.holderCopyright SPRINGER
dc.identifier.doi10.1007/s11357-012-9413-y
dc.identifier.pmid22544617
dc.subject.wosGeriatrics & Gerontology
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
hcfmusp.description.beginpage777
hcfmusp.description.endpage792
hcfmusp.description.issue3
hcfmusp.description.volume35
hcfmusp.origemWOS
hcfmusp.origem.id2-s2.0-84880573451
hcfmusp.origem.idWOS:000318174100020
hcfmusp.publisher.cityDORDRECHT
hcfmusp.publisher.countryNETHERLANDS
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