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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTAMASHIRO-DURAN, Jaqueline Hatsuko
dc.contributor.authorSQUARZONI, Paula
dc.contributor.authorDURAN, Fabio Luis de Souza
dc.contributor.authorCURIATI, Pedro Kallas
dc.contributor.authorVALLADA, Homero Pinto
dc.contributor.authorBUCHPIGUEL, Carlos Alberto
dc.contributor.authorLOTUFO, Paulo Andrade
dc.contributor.authorWAJNGARTEN, Mauricio
dc.contributor.authorMENEZES, Paulo Rossi
dc.contributor.authorSCAZUFCA, Marcia
dc.contributor.authorALVES, Tania Correa de Toledo Ferraz
dc.contributor.authorBUSATTO, Geraldo Filho
dc.identifier.citationAGE, v.35, n.3, p.777-792, 2013
dc.description.abstractCardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein epsilon 4 (APOE epsilon 4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date. The present FDG-PET study investigated 59 cognitively preserved elderlies divided into three groups according to their cardiovascular risk based on the Framingham 10-year risk Coronary Heart Disease Risk Profile (low-, medium-, and high-risk) to examine whether different levels of CVRF would be associated with reduced CMRgl, involving the same brain regions affected in early stages of AD. Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE epsilon 4 allele as a confounding covariate. Significant cerebral metabolism reductions were detected in the high-risk group when compared to the low-risk group in the left precuneus and posterior cingulate gyrus. This suggests that findings of brain hypometabolism similar to those seen in subjects with AD can be detected in association with the severity of cardiovascular risk in cognitively preserved individuals. Thus, a greater knowledge about how such factors influence brain functioning in healthy subjects over time may provide important insigths for the future development of strategies aimed at delaying or preventing the vascular-related triggering of pathologic brain changes in the AD.
dc.subjectAlzheimer's disease
dc.subjectPositron emission tomography
dc.subjectFramingham Heart Study Risk Score
dc.subjectApolipoprotein E
dc.subject.othergender-related differences
dc.subject.othervoxel-based morphometry
dc.subject.othervascular dementia
dc.subject.otherstroke risk
dc.subject.otherendothelial dysfunction
dc.subject.otherinverse association
dc.subject.othermemory impairment
dc.subject.otherf-18-fdg pet
dc.titleCardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations
dc.rights.holderCopyright SPRINGER
dc.subject.wosGeriatrics & Gerontology
dc.type.categoryoriginal article
hcfmusp.relation.referenceAcosta-Cabronero J, 2008, NEUROIMAGE, V39, P1654, DOI 10.1016/j.neuroimage.2007.10.051
hcfmusp.relation.referenceAlves TCDF, 2011, J ALZHEIMERS DIS, V27, P575, DOI 10.3233/JAD-2011-110827
hcfmusp.relation.referenceAlves TCTF, 2005, J NEUROIMAGING, V15, P150, DOI 10.1177/1051228404272880
hcfmusp.relation.referenceANDREASON PJ, 1994, PSYCHIAT RES, V51, P175, DOI 10.1016/0165-1781(94)90037-X
hcfmusp.relation.referenceAshburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
hcfmusp.relation.referenceAshburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
hcfmusp.relation.referenceBaker LD, 2011, ARCH NEUROL-CHICAGO, V68, P51, DOI 10.1001/archneurol.2010.225
hcfmusp.relation.referenceBangen KJ, 2009, NEUROBIOL AGING, V30, P1276, DOI 10.1016/j.neurobiolaging.2007.11.012
hcfmusp.relation.referenceBartenstein P, 2002, EUR J NUCL MED MOL I, V29, pBP43
hcfmusp.relation.referenceBAXTER LR, 1987, PSYCHIAT RES, V21, P237, DOI 10.1016/0165-1781(87)90028-X
hcfmusp.relation.referenceBell RD, 2009, NAT CELL BIOL, V11, P143, DOI 10.1038/ncb1819
hcfmusp.relation.referenceBrett M, 2002, NAT REV NEUROSCI, V3, P243, DOI 10.1038/nrn756
hcfmusp.relation.referenceChetelat G, 2003, BRAIN, V126, P1955, DOI 10.1093/brain/awg196
hcfmusp.relation.referenceChoi BR, 2011, STROKE, V42, P2595, DOI 10.1161/STROKEAHA.111.620179
hcfmusp.relation.referenceCOPELAND JRM, 1986, PSYCHOL MED, V16, P89
hcfmusp.relation.referenceCORDER EH, 1993, SCIENCE, V261, P921, DOI 10.1126/science.8346443
hcfmusp.relation.referenceCraft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
hcfmusp.relation.referenceCuriati PK, 2011, AM J NEURORADIOL, V32, P560, DOI 10.3174/ajnr.A2321
hcfmusp.relation.referencede la Torre JC, 2009, INT REV NEUROBIOL, V84, P35, DOI 10.1016/S0074-7742(09)00403-6
hcfmusp.relation.referenceDELATORRE JC, 1993, NEUROL RES, V15, P146
hcfmusp.relation.referencede la Torre JC, 1999, ACTA NEUROPATHOL, V98, P1
hcfmusp.relation.referencede la Torre JC, 2003, NEUROL RES, V25, P635, DOI 10.1179/016164103101201931
hcfmusp.relation.referenceDrzezga A, 2005, J NUCL MED, V46, P1625
hcfmusp.relation.referenceElias MF, 1997, EXP AGING RES, V23, P201, DOI 10.1080/03610739708254281
hcfmusp.relation.referenceEriksson SH, 2009, HUM BRAIN MAPP, V30, P3351, DOI 10.1002/hbm.20757
hcfmusp.relation.referenceErkinjuntti Timo, 2009, V24, P79, DOI 10.1159/000197886
hcfmusp.relation.referenceFaul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
hcfmusp.relation.referenceFitzpatrick AL, 2009, ARCH NEUROL-CHICAGO, V66, P336, DOI 10.1001/archneurol.2008.582
hcfmusp.relation.referenceFriston KJ, 1996, NEUROIMAGE, V4, P223, DOI 10.1006/nimg.1996.0074
hcfmusp.relation.referenceFujimoto T, 2008, PSYCHIAT RES-NEUROIM, V164, P58, DOI 10.1016/j.pscychresns.2006.12.014
hcfmusp.relation.referenceGimbrone Michael A, 2010, Trans Am Clin Climatol Assoc, V121, P115
hcfmusp.relation.referenceGimbrone MA, 1999, THROMB HAEMOSTASIS, V82, P722
hcfmusp.relation.referenceGorelick PB, 2004, STROKE, V35, P2620, DOI 10.1161/01.STR.000143318.70292.47
hcfmusp.relation.referenceGrammas P, 2011, EXPERT REV MOL MED, V13, DOI 10.1017/S1462399411001918
hcfmusp.relation.referenceGrammas P, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-26
hcfmusp.relation.referenceGrammas P, 2000, NEUROBIOL AGING, V21, P199, DOI 10.1016/S0197-4580(00)00102-0
hcfmusp.relation.referenceIrie F, 2008, ARCH NEUROL-CHICAGO, V65, P89, DOI 10.1001/archneurol.2007.29
hcfmusp.relation.referenceIshii H, 2009, INT PSYCHOGERIATR, V21, P148, DOI 10.1017/S1041610208008132
hcfmusp.relation.referenceJagust William, 2006, Alzheimers Dement, V2, P36, DOI 10.1016/j.jalz.2005.11.002
hcfmusp.relation.referenceJeerakathil T, 2004, STROKE, V35, P1857, DOI 10.1161/01.STR.0000135226.53499.85
hcfmusp.relation.referenceKawachi T, 2006, EUR J NUCL MED MOL I, V33, P801, DOI 10.1007/s00259-005-0050-x
hcfmusp.relation.referenceKitagawa K, 2010, J ALZHEIMERS DIS, V20, P855, DOI 10.3233/JAD-2010-091324
hcfmusp.relation.referenceKivipelto M, 2008, J CELL MOL MED, V12, P2762, DOI 10.1111/j.1582-4934.2008.00296.x
hcfmusp.relation.referenceKnopman D, 2001, NEUROLOGY, V56, P42
hcfmusp.relation.referenceKuczynski B, 2009, NEUROLOGY, V72, P738, DOI 10.1212/01.wnl.0000343005.35498.e5
hcfmusp.relation.referenceKumar-Singh S, 2008, GENES BRAIN BEHAV, V7, P67, DOI 10.1111/j.1601-183X.2007.00380.x
hcfmusp.relation.referenceLangbaum JB, 2012, NEUROBIOL AGING, V33
hcfmusp.relation.referenceLangbaum JBS, 2010, ARCH NEUROL-CHICAGO, V67, P462, DOI 10.1001/archneurol.2010.30
hcfmusp.relation.referenceLauner LJ, 2000, NEUROBIOL AGING, V21, P49, DOI 10.1016/S0197-4580(00)00096-8
hcfmusp.relation.referenceLi J, 2011, NEUROLOGY, V76, P1485, DOI 10.1212/WNL.0b013e318217e7a4
hcfmusp.relation.referenceLibby P, 2009, J LIPID RES, V50, pS352, DOI 10.1194/jlr.R800099-JLR200
hcfmusp.relation.referenceMassaro JM, 2004, STAT MED, V23, P351, DOI 10.1002/sim.1743
hcfmusp.relation.referenceMeigs JB, 1997, AM J MED, V102, P38
hcfmusp.relation.referenceMeltzer CC, 2000, J NUCL MED, V41, P1842
hcfmusp.relation.referenceMenon U, 2009, INT REV NEUROBIOL, V84, P21, DOI 10.1016/S0074-7742(09)00402-4
hcfmusp.relation.referenceMesulam M.-Marsel, 1999, Neuron, V24, P521, DOI 10.1016/S0896-6273(00)81109-5
hcfmusp.relation.referenceMeyer JS, 2000, ANN NY ACAD SCI, V903, P411, DOI 10.1111/j.1749-6632.2000.tb06393.x
hcfmusp.relation.referenceMinoshima S, 1997, ANN NEUROL, V42, P85, DOI 10.1002/ana.410420114
hcfmusp.relation.referenceMosconi L, 2008, BIOL PSYCHIAT, V63, P609, DOI 10.1016/j.biopsych.2007.05.030
hcfmusp.relation.referenceMosconi L, 2008, J NUCL MED, V49, P390, DOI 10.2967/jnumed.107.045385
hcfmusp.relation.referenceMosconi L, 2005, EUR J NUCL MED MOL I, V32, P486, DOI 10.1007/s00259-008-1039-z
hcfmusp.relation.referenceMosconi Lisa, 2004, Expert Rev Neurother, V4, P831, DOI 10.1586/14737175.4.5.831
hcfmusp.relation.referenceObisesan TO, 2008, J AM GERIATR SOC, V56, P501, DOI 10.1111/j.1532-5415.2007.01592.x
hcfmusp.relation.referencePereira JMS, 2010, NEUROIMAGE, V49, P2205, DOI 10.1016/j.neuroimage.2009.10.068
hcfmusp.relation.referencePetrie EC, 2009, ARCH NEUROL-CHICAGO, V66, P632, DOI 10.1001/archneurol.2009.59
hcfmusp.relation.referencePrince M, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-165
hcfmusp.relation.referenceQiu Chengxuan, 2009, Dialogues Clin Neurosci, V11, P111
hcfmusp.relation.referenceQuarantelli M, 2004, J NUCL MED, V45, P192
hcfmusp.relation.referenceRazay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
hcfmusp.relation.referenceReiman EM, 2004, P NATL ACAD SCI USA, V101, P284, DOI 10.1073/pnas.2635903100
hcfmusp.relation.referenceReiman EM, 2010, NEUROIMAGE, V49, P169, DOI 10.1016/j.neuroimage.2009.07.025
hcfmusp.relation.referenceRosendoff C, 2007, AM J GERIATR CARDIOL, V16, P143, DOI 10.1111/j.1076-7460.2007.06696.x
hcfmusp.relation.referenceSalmina AB, 2010, J ALZHEIMERS DIS, V22, P17, DOI 10.3233/JAD-2010-091690
hcfmusp.relation.referenceScazufca M, 2008, INT PSYCHOGERIATR, V20, P394, DOI 10.1017/S1041610207005625
hcfmusp.relation.referenceScazufca M, 2008, INT J EPIDEMIOL, V37, P721, DOI 10.1093/ije/dym154
hcfmusp.relation.referenceSeshadri S, 2004, NEUROLOGY, V63, P1591
hcfmusp.relation.referenceSeshadri S, 2006, INT REV PSYCHIATR, V18, P409, DOI 10.1080/09540260600935413
hcfmusp.relation.referenceSmith SM, 2002, NEUROIMAGE, V17, P479, DOI 10.1006/nimg.2002.1040
hcfmusp.relation.referenceSmith SM, 2001, J COMPUT ASSIST TOMO, V25, P466, DOI 10.1097/00004728-200105000-00022
hcfmusp.relation.referenceStuerenburg HJ, 2005, NEUROENDOCRINOL LETT, V26, P261
hcfmusp.relation.referenceTalairach J., 1988, COPLANAR STEREOTAXIC
hcfmusp.relation.referenceTeipel SJ, 2009, J ALZHEIMERS DIS, V17, P571, DOI 10.3233/JAD-2009-1077
hcfmusp.relation.referenceVander Borght T, 2001, ACTA NEUROL BELG, V101, P196
hcfmusp.relation.referenceViswanathan A, 2009, NEUROLOGY, V72, P368, DOI 10.1212/01.wnl.0000341271.90478.8e
hcfmusp.relation.referenceVolkow ND, 2009, OBESITY, V17, P60, DOI 10.1038/oby.2008.469
hcfmusp.relation.referenceWang XJ, 2010, J ALZHEIMERS DIS, V21, P813, DOI 10.3233/JAD-2010-100216
hcfmusp.relation.referenceWilson PWF, 1998, CIRCULATION, V97, P1837
hcfmusp.relation.referenceXu WL, 2009, DIABETES, V58, P71, DOI 10.2337/db08-0586
hcfmusp.relation.referenceYOSHII F, 1988, J CEREBR BLOOD F MET, V8, P654
hcfmusp.relation.referenceZlokovic BV, 2005, TRENDS NEUROSCI, V28, P202, DOI 10.1016/j.tins.2005.02.001
hcfmusp.relation.referenceZlokovic BV, 2010, NAT MED, V16, P1370, DOI 10.1038/nm1210-1370
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