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Title: Bone marrow mononuclear cell therapy in experimental allergic asthma: Intratracheal versus intravenous administration
Authors: ABREU, Soraia C.ANTUNES, Mariana A.MARON-GUTIERREZ, TatianaCRUZ, Fernanda F.ORNELLAS, Debora S.SILVA, Adriana L.DIAZ, Bruno L.AB'SABER, Alexandre M.CAPELOZZI, Vera L.XISTO, Debora G.MORALES, Marcelo M.ROCCO, Patricia R. M.
Citation: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.185, n.3, p.615-624, 2013
Abstract: We hypothesized that the route of administration would impact the beneficial effects of bone marrow-derived mononuclear cell (BMDMC) therapy on the remodelling process of asthma. C57BL/6 mice were randomly assigned to two main groups. In the OVA group, mice were sensitized and challenged with ovalbumin, while the control group received saline using the same protocol. Twenty-four hours before the first challenge, control and OVA animals were further randomized into three subgroups to receive saline (SAL), BMDMCs intravenously (2 x 10(6)), or BMDMCs intratracheally (2 x 10(6)). The following changes were induced by BMDMC therapy in OVA mice regardless of administration route: reduction in resistive and viscoelastic pressures, static elastance, eosinophil infiltration, collagen fibre content in airways and lung parenchyma; and reduction in the levels of interleukin (IL)-4, IL-13, transforming growth factor-beta and vascular endothelial growth factor. In conclusion, BMDMC modulated inflammatory and remodelling processes regardless of administration route in this experimental model of allergic asthma.
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Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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