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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMELO, Marcelo Dantas Tavares de-
dc.contributor.authorGIORGI, Maria Clementina Pinto-
dc.contributor.authorASSUNCAO JR., Antonildes Nascimento-
dc.contributor.authorDANTAS JR., Roberto Nery-
dc.contributor.authorARAUJO FILHO, Jose de Arimateia-
dc.contributor.authorPARGA FILHO, Jose Rodrigues-
dc.contributor.authorBIERRENBACH, Ana Luiza de Souza-
dc.contributor.authorLIMA, Camila Rocon de-
dc.contributor.authorSOARES JR., Jose-
dc.contributor.authorMENEGUETTI, Jose Claudio-
dc.contributor.authorMADY, Charles-
dc.contributor.authorHAJJAR, Ludhmila Abrahao-
dc.contributor.authorKALIL FILHO, Roberto-
dc.contributor.authorBOCCHI, Edimar Alcides-
dc.contributor.authorSALEMI, Vera Maria Cury-
dc.identifier.citationEUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, v.18, n.8, p.915-921, 2017-
dc.description.abstractAims The pathophysiological mechanisms of left ventricular non-compaction cardiomyopathy (LVNC) remain controversial. This study performed combined F-18-fluoro-2-deoxyglucose dynamic positron emission tomography (FDG-PET) and 99mTc-sestamibi single-photon emission computed tomography (SPECT) studies to evaluate myocardial glucose metabolism and perfusion in patients with LVNC and their clinical implications. Methods and results Thirty patients (41 +/- 12 years, 53% male) with LVNC, diagnosed by cardiovascular magnetic resonance (CMR) criteria, and eight age-matched healthy controls (42 +/- 12 years, 50% male) were prospectively recruited to undergo FDG-PET with measurement of the myocardial glucose uptake rate (MGU) and SPECT to investigate perfusion-metabolism patterns. Patients with LVNC had lower global MGU compared with that in controls (36.9 +/- 8.8 vs. 44.6 +/- 5.4 mu mol/min/100 g, respectively, P = 0.02). Of 17 LV segments, MGU levels were significantly reduced in 8, and also a reduction was observed when compacted segments from LVNC were compared with the segments from control subjects (P < 0.001). Perfusion defects were also found in 15 (50%) patients (45 LV segments: 64.4% match, and 35.6% mismatch perfusion-metabolism pattern). Univariate and multivariate analyses showed that beta-blocker therapy was associated with increased MGU (beta coefficient = 10.1, P = 0.008). Moreover, a gradual increase occurred in MGU across the beta-blocker dose groups (P for trend = 0.01). Conclusion The reduction of MGU documented by FDG-PET in LVNC supports the hypothesis that a cellular metabolic pathway may play a role in the pathophysiology of LVNC. The beneficial effect of beta-blocker mediating myocardial.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP-2010/18939-3]-
dc.publisherOXFORD UNIV PRESS-
dc.relation.ispartofEuropean Heart Journal-Cardiovascular Imaging-
dc.subject.otherventricular non-compaction-
dc.subject.otheridiopathic dilated cardiomyopathy-
dc.titleDecreased glycolytic metabolism in non-compaction cardiomyopathy by F-18-fluoro-2-deoxyglucose positron emission tomography: new insights into pathophysiological mechanisms and clinical implications-
dc.rights.holderCopyright OXFORD UNIV PRESS-
dc.subject.wosCardiac & Cardiovascular Systems-
dc.subject.wosRadiology, Nuclear Medicine & Medical Imaging-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Ana Luiza de Souza:Hosp Sirio Libanes, Indeed Teaching & Res Inst, Sao Paulo, Brazil-, Ludhmila Abrahao:Hosp Sirio Libanes, Indeed Teaching & Res Inst, Sao Paulo, Brazil- FILHO, Roberto:Hosp Sirio Libanes, Indeed Teaching & Res Inst, Sao Paulo, Brazil-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

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