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Title: Ambient levels of concentrated PM2.5 affects cell kinetics in adrenal glands: an experimental study in mice
Authors: FUCHS, Luiz Fernando PortugalVERAS, Mariana MateraSALDIVA, Paulo Hilario NascimentoSASSO, Gisela Rodrigues da SilvaCARVALHO, Katia CandidoSIMOES, Manuel de JesusSOARES JR., Jose MariaBARACAT, Edmund Chada
Citation: GYNECOLOGICAL ENDOCRINOLOGY, v.33, n.6, p.490-495, 2017
Abstract: We evaluated the effects of air pollution on the adrenal cortex using 30 female mice divided into two groups of fifteen animals each. One group was conditioned daily in a chamber with exposure to particulate matter (PM) 2.5 mu m (GExp). Animals were exposed on daily basis in an ambient particles concentrator during the period of time enough to reach an accumulated dose of 600 mu g/m(3), which corresponds to a 24-h exposure of 25 mu g/m(3) that approximates to the annual mean of PM2.5 in Sao Paulo. The other group was allocated to another chamber with filtered air (GCrt). After euthanasia, the adrenals underwent histological processing and immunohistochemistry staining for Ki-67 and cleaved caspase-3. Histomorphometry of the adrenal glands in GExp showed increased thickness of the zona glomerulosa, while in GCrt; the adrenal glands from GExp had higher Ki-67 immunostaining scores in the zona reticularis than those from GCrt. The adrenal from GExp showed higher cleaved caspase-3 immunoreactivity in the zona fasciculata than the unexposed group (GCrt). The homeostasis index indicated higher cell proliferation in the zona glomerulosa and zona reticularis in GExp than in GCrt. Our data indicate that PM2.5 air pollution induces alterations on cell kinetics in mouse adrenal glands.
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

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Instituto Central - HC/ICHC

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Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

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LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

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ODS/11 - Cidades e comunidades sustentáveis

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