https://observatorio.fm.usp.br/handle/OPI/22020
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | FUCHS, Luiz Fernando Portugal | - |
dc.contributor.author | VERAS, Mariana Matera | - |
dc.contributor.author | SALDIVA, Paulo Hilario Nascimento | - |
dc.contributor.author | SASSO, Gisela Rodrigues da Silva | - |
dc.contributor.author | CARVALHO, Katia Candido | - |
dc.contributor.author | SIMOES, Manuel de Jesus | - |
dc.contributor.author | SOARES JR., Jose Maria | - |
dc.contributor.author | BARACAT, Edmund Chada | - |
dc.date.accessioned | 2017-10-24T13:21:54Z | - |
dc.date.available | 2017-10-24T13:21:54Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | GYNECOLOGICAL ENDOCRINOLOGY, v.33, n.6, p.490-495, 2017 | - |
dc.identifier.issn | 0951-3590 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/22020 | - |
dc.description.abstract | We evaluated the effects of air pollution on the adrenal cortex using 30 female mice divided into two groups of fifteen animals each. One group was conditioned daily in a chamber with exposure to particulate matter (PM) 2.5 mu m (GExp). Animals were exposed on daily basis in an ambient particles concentrator during the period of time enough to reach an accumulated dose of 600 mu g/m(3), which corresponds to a 24-h exposure of 25 mu g/m(3) that approximates to the annual mean of PM2.5 in Sao Paulo. The other group was allocated to another chamber with filtered air (GCrt). After euthanasia, the adrenals underwent histological processing and immunohistochemistry staining for Ki-67 and cleaved caspase-3. Histomorphometry of the adrenal glands in GExp showed increased thickness of the zona glomerulosa, while in GCrt; the adrenal glands from GExp had higher Ki-67 immunostaining scores in the zona reticularis than those from GCrt. The adrenal from GExp showed higher cleaved caspase-3 immunoreactivity in the zona fasciculata than the unexposed group (GCrt). The homeostasis index indicated higher cell proliferation in the zona glomerulosa and zona reticularis in GExp than in GCrt. Our data indicate that PM2.5 air pollution induces alterations on cell kinetics in mouse adrenal glands. | - |
dc.language.iso | eng | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.ispartof | Gynecological Endocrinology | - |
dc.rights | restrictedAccess | - |
dc.subject | Adrenal | - |
dc.subject | mouse | - |
dc.subject | PM2.5 | - |
dc.subject | traffic | - |
dc.subject | urban pollution | - |
dc.subject.other | air-pollution | - |
dc.subject.other | particulate matter | - |
dc.subject.other | oxidative stress | - |
dc.subject.other | gene-expression | - |
dc.subject.other | health | - |
dc.subject.other | toxicity | - |
dc.subject.other | cortex | - |
dc.subject.other | lead | - |
dc.title | Ambient levels of concentrated PM2.5 affects cell kinetics in adrenal glands: an experimental study in mice | - |
dc.type | article | - |
dc.rights.holder | Copyright TAYLOR & FRANCIS LTD | - |
dc.identifier.doi | 10.1080/09513590.2017.1291617 | - |
dc.identifier.pmid | 28277123 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.subject.wos | Obstetrics & Gynecology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | FUCHS, Luiz Fernando Portugal:Univ Sao Paulo FMUSP, Dept Obstet & Ginecol, Lab Invest Med LIM 58, Disciplina Ginecol,Hosp Clin,Fac Med, Sao Paulo, Brazil | - |
hcfmusp.author.external | SASSO, Gisela Rodrigues da Silva:Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Histol & Biol Estrutural, Dept Morfol & Genet, Sao Paulo, Brazil | - |
hcfmusp.author.external | SIMOES, Manuel de Jesus:Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Histol & Biol Estrutural, Dept Morfol & Genet, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 490 | - |
hcfmusp.description.endpage | 495 | - |
hcfmusp.description.issue | 6 | - |
hcfmusp.description.volume | 33 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-85014450506 | - |
hcfmusp.origem.id | WOS:000407685700017 | - |
hcfmusp.publisher.city | ABINGDON | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1473-0766 | - |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - LIM/58 Artigos e Materiais de Revistas Científicas - ODS/11 |
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art_FUCHS_Ambient_levels_of_concentrated_PM25_affects_cell_kinetics_2017.PDF Restricted Access | publishedVersion (English) | 1.83 MB | Adobe PDF | View/Open Request a copy |
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