Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/22146
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | DARTORA, Daniela Ravizzoni | - |
dc.contributor.author | IRIGOYEN, Maria-Claudia | - |
dc.contributor.author | CASALI, Karina Rabello | - |
dc.contributor.author | MORAES-SILVA, Ivana C. | - |
dc.contributor.author | BERTAGNOLLI, Mariane | - |
dc.contributor.author | BADER, Michael | - |
dc.contributor.author | SANTOS, Robson A. S. | - |
dc.date.accessioned | 2017-10-24T13:23:46Z | - |
dc.date.available | 2017-10-24T13:23:46Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, v.95, n.9, p.993-998, 2017 | - |
dc.identifier.issn | 0008-4212 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/22146 | - |
dc.description.abstract | Angiotensin-(1-7) counterbalances angiotensin II cardiovascular effects. However, it has yet to be determined how cardiovascular autonomic modulation may be affected by chronic and acute elevation of Ang-(1-7). Hemodynamics and cardiovascular autonomic profile were evaluated in male Sprague-Dawley (SD) rats and transgenic rats (TGR) overexpressing Ang-(1-7) [TGR(A1-7) 3292]. Blood pressure (BP) was directly measured while cardiovascular autonomic modulation was evaluated by spectral analysis. TGR received A-779 or vehicle and SD rats received Ang-(1-7) or vehicle and were monitored for 5 h after i.v. administration. In another set of experiments with TGR, A-779 was infused for 7 days using osmotic mini pumps. Although at baseline no differences were observed, acute administration of A-779 in TGR produced a marked long-lasting increase in BP accompanied by increased BP variability (BPV) and sympathetic modulation to the vessels. Likewise, chronic administration of A-779 with osmotic mini pumps in TGR increased heart rate, sympathovagal balance, BPV, and sympathetic modulation to the vessels. Administration of Ang-(1-7) to SD rats increased heart rate variability values in 88% accompanied by 8% of vagal modulation increase and 18% of mean BP reduction. These results show that both acute and chronic alteration in the Ang-(1-7)-Mas receptor axis may lead to important changes in the autonomic control of circulation, impacting either sympathetic and (or) parasympathetic systems. | - |
dc.description.sponsorship | CAPES | - |
dc.description.sponsorship | FAPEMIG | - |
dc.description.sponsorship | CNPQ | - |
dc.description.sponsorship | FAPERGS | - |
dc.language.iso | eng | - |
dc.publisher | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS | - |
dc.relation.ispartof | Canadian Journal of Physiology and Pharmacology | - |
dc.rights | restrictedAccess | - |
dc.subject | renin-angiotensin system | - |
dc.subject | angiotensin-(1-7) | - |
dc.subject | A-779 | - |
dc.subject | blood pressure | - |
dc.subject | autonomic nervous system | - |
dc.subject | heart rate variability | - |
dc.subject | spectral analysis | - |
dc.subject.other | renin-angiotensin system | - |
dc.subject.other | baroreceptor reflex modulation | - |
dc.subject.other | heart-rate-variability | - |
dc.subject.other | hypertensive-rats | - |
dc.subject.other | blood-pressure | - |
dc.subject.other | circulating angiotensin-(1-7) | - |
dc.subject.other | baroreflex modulation | - |
dc.subject.other | infusion | - |
dc.subject.other | stress | - |
dc.subject.other | mice | - |
dc.title | Improved cardiovascular autonomic modulation in transgenic rats expressing an Ang-(1-7)-producing fusion protein | - |
dc.type | article | - |
dc.rights.holder | Copyright CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS | - |
dc.identifier.doi | 10.1139/cjpp-2016-0557 | - |
dc.identifier.pmid | 28459154 | - |
dc.subject.wos | Pharmacology & Pharmacy | - |
dc.subject.wos | Physiology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | DARTORA, Daniela Ravizzoni:Univ Fdn Cardiol, Cardiol Inst Rio Grande Sul, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | CASALI, Karina Rabello:Univ Fdn Cardiol, Cardiol Inst Rio Grande Sul, Porto Alegre, RS, Brazil; Fed Univ Sao Paulo UNIFESP, Sci & Technol Inst ICT, Sao Paulo, Brazil | - |
hcfmusp.author.external | BERTAGNOLLI, Mariane:CHU St Justine Res Ctr, Montreal, PQ, Canada | - |
hcfmusp.author.external | BADER, Michael:Max Delbruck Ctr Mol Med MDC, Berlin, Germany | - |
hcfmusp.author.external | SANTOS, Robson A. S.:Univ Fdn Cardiol, Cardiol Inst Rio Grande Sul, Porto Alegre, RS, Brazil; Univ Fed Minas Gerais, Natl Inst Sci & Technol Nanobiopharm, Inst Biol Sci, Dept Physiol & Biophys, Belo Horizonte, MG, Brazil | - |
hcfmusp.description.beginpage | 993 | - |
hcfmusp.description.endpage | 998 | - |
hcfmusp.description.issue | 9 | - |
hcfmusp.description.volume | 95 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000408322600002 | - |
hcfmusp.origem.id | 2-s2.0-85019708744 | - |
hcfmusp.publisher.city | OTTAWA | - |
hcfmusp.publisher.country | CANADA | - |
hcfmusp.relation.reference | Alzamora AC, 2006, AM J PHYSIOL-REG I, V290, pR1027, DOI 10.1152/ajpregu.00852.2004 | - |
hcfmusp.relation.reference | Baltatu OC, 2011, PEPTIDES, V32, P1083, DOI 10.1016/j.peptides.2011.02.008 | - |
hcfmusp.relation.reference | Bertagnolli M, 2014, PEPTIDES, V51, P65, DOI 10.1016/j.peptides.2013.11.006 | - |
hcfmusp.relation.reference | Botelho-Santos GA, 2007, AM J PHYSIOL-HEART C, V292, pH2485, DOI 10.1152/ajpheart.01245.2006 | - |
hcfmusp.relation.reference | Braga ANG, 2002, AM J PHYSIOL-REG I, V282, pR1663, DOI 10.1152/ajpregu.00583.2001 | - |
hcfmusp.relation.reference | Britto RR, 1997, HYPERTENSION, V30, P549 | - |
hcfmusp.relation.reference | CAMPAGNOLESANTOS MJ, 1992, AM J PHYSIOL, V263, pR89 | - |
hcfmusp.relation.reference | CAMPAGNOLESANTOS MJ, 1988, HYPERTENSION, V11, P167 | - |
hcfmusp.relation.reference | Fazan R, 2005, AM J PHYSIOL-HEART C, V289, pH1968, DOI 10.1152/ajpheart.01224.2004 | - |
hcfmusp.relation.reference | Feng YM, 2010, CIRC RES, V106, P373, DOI 10.1161/CIRCRESAHA.109.208645 | - |
hcfmusp.relation.reference | Ferrario CM, 2011, CURR OPIN NEPHROL HY, V20, P1, DOI 10.1097/MNH.0b013e3283406f57 | - |
hcfmusp.relation.reference | Ferreira AJ, 2011, J HISTOCHEM CYTOCHEM, V59, P761, DOI 10.1369/0022155411411712 | - |
hcfmusp.relation.reference | Fraga-Silva RA, 2008, MOL MED, V14, P28, DOI 10.2119/2007-00073.Fraga-Silva0 | - |
hcfmusp.relation.reference | Freeman EJ, 1996, HYPERTENSION, V28, P104 | - |
hcfmusp.relation.reference | Guimaraes GG, 2012, PEPTIDES, V38, P54, DOI 10.1016/j.peptides.2012.05.024 | - |
hcfmusp.relation.reference | Herath CB, 2013, AM J PHYSIOL-GASTR L, V304, pG99, DOI 10.1152/ajpgi.00163.2012 | - |
hcfmusp.relation.reference | Klein N, 2013, CRIT CARE MED, V41, pE334, DOI 10.1097/CCM.0b013e31828a6688 | - |
hcfmusp.relation.reference | Kluskens LD, 2009, J PHARMACOL EXP THER, V328, P849, DOI 10.1124/jpet.108.146431 | - |
hcfmusp.relation.reference | Lautner RQ, 2013, CIRC RES, V112, P1104, DOI 10.1161/CIRCRESAHA.113.301077 | - |
hcfmusp.relation.reference | MALLIANI A, 1991, CIRCULATION, V84, P482 | - |
hcfmusp.relation.reference | Xavier C. H., 2013, AM J PHYSIOL-HEART C, V305, pH1057, DOI [10.1152/ajpheart.00433.2013, DOI 10.1152/AJPHEART.00433.2013] | - |
hcfmusp.relation.reference | McKinley MJ, 2003, INT J BIOCHEM CELL B, V35, P901, DOI 10.1016/S1357-2725(02)00306-0 | - |
hcfmusp.relation.reference | Moraes-Silva IC, 2010, CLIN EXP PHARMACOL P, V37, pe114, DOI 10.1111/j.1440-1681.2009.05333.x | - |
hcfmusp.relation.reference | Moreira ED, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.45 | - |
hcfmusp.relation.reference | National Research Council, 2011, GUIDE CARE USE LAB A, DOI [10.17226/12910, DOI 10.17226/12910] | - |
hcfmusp.relation.reference | Oliveira DR, 1996, HYPERTENSION, V27, P1284 | - |
hcfmusp.relation.reference | Oscar CG, 2015, BRAIN RES, V1594, P183, DOI 10.1016/j.brainres.2014.11.006 | - |
hcfmusp.relation.reference | Oudit GY, 2003, TRENDS CARDIOVAS MED, V13, P93, DOI 10.1016/S1050-1738(02)00233-5 | - |
hcfmusp.relation.reference | Pagani M, 1997, CIRCULATION, V95, P1441 | - |
hcfmusp.relation.reference | PARATI G, 1995, HYPERTENSION, V25, P1276 | - |
hcfmusp.relation.reference | Reudelhuber TL, 2011, HYPERTENSION, V57, P532, DOI 10.1161/HYPERTENSIONAHA.110.167114 | - |
hcfmusp.relation.reference | Sampaio WO, 2003, AM J PHYSIOL-HEART C, V284, pH1985, DOI 10.1152/ajpheart.01145.2002 | - |
hcfmusp.relation.reference | Santiago NM, 2010, HYPERTENSION, V55, P889, DOI 10.1161/HYPERTENSIONAHA.110.149815 | - |
hcfmusp.relation.reference | Santos RAS, 2004, PHYSIOL GENOMICS, V17, P292, DOI 10.1152/physiolgenomics.00227.2003 | - |
hcfmusp.relation.reference | Santos RAS, 2008, EXP PHYSIOL, V93, P519, DOI 10.1113/expphysiol.2008.042002 | - |
hcfmusp.relation.reference | Santos RA, 2014, HYPERTENSION, V63, P1138, DOI 10.1161/HYPERTENSIONAHA.113.01274 | - |
hcfmusp.relation.reference | Santos SHS, 2010, ARTERIOSCL THROM VAS, V30, P953, DOI 10.1161/ATVBAHA.109.200493 | - |
hcfmusp.relation.reference | Silva DMR, 2007, PEPTIDES, V28, P702, DOI 10.1016/j.peptides.2006.10.007 | - |
hcfmusp.relation.reference | Simoes ES, 2013, BRIT J PHARMACOL, V169, P477, DOI 10.1111/BPH.12159 | - |
hcfmusp.relation.reference | Santos SHS, 2014, PEPTIDES, V59, P34, DOI 10.1016/j.peptides.2014.07.002 | - |
hcfmusp.relation.reference | Zimmerman MC, 2004, CIRC RES, V95, P210, DOI 10.1161/01.RES.0000135483.12297.e4 | - |
dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1205-7541 | - |
hcfmusp.citation.scopus | 7 | - |
hcfmusp.scopus.lastupdate | 2024-03-08 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/59 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.