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https://observatorio.fm.usp.br/handle/OPI/22448
Title: | Comparison of Clamping Modalities in a Rabbit Model of Normothermic Renal Ischemia |
Authors: | FORMIGA, Cipriano C.; MITRE, Anuar I.; CASTILHO, Lisias N.; BUCHPIGUEL, Carlos Alberto; MARQUES, Fabio L. N.; RADIN, Adriano; SROUGI, Miguel |
Citation: | JOURNAL OF ENDOUROLOGY, v.25, n.11, p.1787-1791, 2011 |
Abstract: | Purpose: The objective of this study was to investigate the patterns of renal function recovery with different renal vessel clamping modalities during a prolonged warm ischemia (WI) condition in an experimental two-kidney rabbit model. Materials and Methods: Twenty-eight rabbits were randomly clustered into four groups and underwent laparotomy with different types of renal pedicle clamping. Group 1 (n = 4) was sham-operated. Group 2 (n = 8) underwent 80 minutes of WI with artery only clamping. Group 3 (n = 8) underwent arteriovenous clamping for 80 minutes, and group 4 (n = 8) received an arteriovenous clamping for 80 minutes with 10-second declamping periods every 20 minutes. Serum levels of creatinine (SCr) were recorded preoperatively and on postoperative days (PODs) 1, 3, and 7. Renal function was evaluated by (99m)technetium-mercaptoacetyltriglycine scintigraphy. Afterward, the animals were euthanized, and the kidneys were harvested and evaluated microscopically. Results: Renal function completely recuperated on POD 7 in the groups that underwent artery only and ateriovenous intermittent clamping, and both of these methods were superior to ateriovenous clamping (P < 0.001). SCr showed a similar variation in all the clamping groups and did not demonstrate statistical differences among the groups. Histopathologic changes were similar among the ischemic groups. Conclusion: The less deleterious clamping modalities in this experimental model were the artery only and intermittent en bloc clamping methods. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/43 Artigos e Materiais de Revistas Científicas - LIM/55 |
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