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https://observatorio.fm.usp.br/handle/OPI/2272
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | DENADAI, Rafael | - |
dc.contributor.author | TEIXEIRA, Fabio Vieira | - |
dc.contributor.author | STEINWURZ, Flavio | - |
dc.contributor.author | ROMITI, Ricardo | - |
dc.contributor.author | SAAD-HOSSNE, Rogerio | - |
dc.date.accessioned | 2013-09-23T16:50:36Z | - |
dc.date.available | 2013-09-23T16:50:36Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF CROHNS & COLITIS, v.7, n.7, p.517-524, 2013 | - |
dc.identifier.issn | 1873-9946 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/2272 | - |
dc.description.abstract | Background: Paradoxical cases of psoriatic lesions induced or exacerbated by anti-tumor necrosis factor (TNF)-alpha therapy have been reported more frequently in recent years, but data related to inflammatory bowel disease (IBD) are rare. A systematic literature review was performed to provide information about this adverse effect in patients with IBD who receive anti-TNF therapy. Methods: Published studies were identified by a search of Medline, Embase, Cochrane, SciELO, and LILACS databases. Results: A total of 47 studies (222 patients) fulfilled the inclusion criteria and were selected for analysis. Clinical and therapeutic aspects varied considerably among these reports. Of the 222 patients, 78.38% were diagnosed with Crohn's disease, and 48.20% were female. The mean patient age was 26.50 years, and 70.72% of patients had no history of psoriasis. Patients developed psoriasiform lesions (55.86%) more often than other types of psoriatic lesions, and infliximab was the anti-TNF-alpha therapy that caused the cutaneous reaction in most patients (69.37%). Complete remission of cutaneous lesions was observed in 63.96% of the cases. Conclusions: We found that psoriatic lesions occurred predominantly in adult patients with Crohn's disease who received infliximab and had no previous history of psoriasis. Most patients can be managed conservatively without discontinuing anti-INF-alpha therapy. | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.ispartof | Journal of Crohns & Colitis | - |
dc.rights | restrictedAccess | - |
dc.subject | Adalimumab | - |
dc.subject | Certolizumab | - |
dc.subject | Inflammatory bowel disease | - |
dc.subject | Infliximab | - |
dc.subject | Psoriasis | - |
dc.subject | Biological therapy | - |
dc.subject.other | adalimumab-induced psoriasis | - |
dc.subject.other | factor antagonist therapy | - |
dc.subject.other | necrosis factor therapy | - |
dc.subject.other | single-center cohort | - |
dc.subject.other | crohns-disease | - |
dc.subject.other | skin-lesions | - |
dc.subject.other | infliximab treatment | - |
dc.subject.other | autoimmune-diseases | - |
dc.subject.other | pustular psoriasis | - |
dc.subject.other | certolizumab pegol | - |
dc.title | Induction or exacerbation of psoriatic lesions during anti-TNF-alpha therapy for inflammatory bowel disease: A systematic literature review based on 222 cases | - |
dc.type | article | - |
dc.rights.holder | Copyright ELSEVIER SCIENCE BV | - |
dc.identifier.doi | 10.1016/j.crohns.2012.08.007 | - |
dc.identifier.pmid | 22960136 | - |
dc.subject.wos | Gastroenterology & Hepatology | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | DENADAI, Rafael:Univ State Sao Paulo UNESP, Sch Med Sci, Dept Surg, Div Coloproctol, Botucatu, SP, Brazil | - |
hcfmusp.author.external | TEIXEIRA, Fabio Vieira:Univ State Sao Paulo UNESP, Sch Med Sci, Dept Surg, Div Coloproctol, Botucatu, SP, Brazil | - |
hcfmusp.author.external | STEINWURZ, Flavio:Hosp Israelita Albert Einstein, Unit Inflammatory Bowel Dis, Sao Paulo, Brazil | - |
hcfmusp.author.external | SAAD-HOSSNE, Rogerio:Univ State Sao Paulo UNESP, Sch Med Sci, Dept Surg, Div Coloproctol, Botucatu, SP, Brazil | - |
hcfmusp.description.beginpage | 517 | - |
hcfmusp.description.endpage | 524 | - |
hcfmusp.description.issue | 7 | - |
hcfmusp.description.volume | 7 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84878657106 | - |
hcfmusp.origem.id | WOS:000321079500001 | - |
hcfmusp.publisher.city | AMSTERDAM | - |
hcfmusp.publisher.country | NETHERLANDS | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 94 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - ODS/03 |
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