Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2280
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCUNHA, Lucas Leite-
dc.contributor.authorMARCELLO, Marjory Alana-
dc.contributor.authorMORARI, Elaine Cristina-
dc.contributor.authorNONOGAKI, Suely-
dc.contributor.authorCONTE, Fabio Frangiotti-
dc.contributor.authorGERHARD, Rene-
dc.contributor.authorSOARES, Fernando Augusto-
dc.contributor.authorVASSALLO, Jose-
dc.contributor.authorWARD, Laura Sterian-
dc.date.accessioned2013-09-23T16:50:37Z-
dc.date.available2013-09-23T16:50:37Z-
dc.date.issued2013-
dc.identifier.citationENDOCRINE-RELATED CANCER, v.20, n.1, p.103-110, 2013-
dc.identifier.issn1351-0088-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2280-
dc.description.abstractB7H1 is consistently associated with inhibition of the immune system in many solid tumors. However, there is no report about its impact on differentiated thyroid carcinoma (DTC) presentation, aggressiveness, or evolution. Aiming to investigate the role of B7H1 in DTC and correlate this protein with other tumor-infiltrating immune cells, we studied 407 thyroid nodule tissue samples including 293 from DTC patients, all managed according to a same standard protocol. In addition, we obtained 5 normal and 114 benign thyroid lesions. Eighteen out of the 253 papillary thyroid carcinomas were paired with respective metastatic lymph node tissues. B7H1 (CD274) protein expression was assessed by immunohistochemistry and the gene expression was quantified by real-time PCR. Malignant tissues displayed a more intense B7H1 staining and higher mRNA levels than benign tissues (both P<0.0001). We observed a positive linear correlation between higher age at diagnosis and B7H1 mRNA levels (P=0.02896). Elevated levels of B7H1 protein were associated with the presence of CD4+, CD8+, CD20+, and FoxP3+ lymphocytes (all P<0.05); tumor-associated macro-phages (P<0.0001); and the presence of myeloid-derived suppressor cells (P=0.03256). Stage II-IV patients presented higher B7H1 mRNA levels than stage I cases (P=0.03522). On the contrary, a decreased expression of B7H1 protein was observed in lymph node metastasis (P=0.0152). In conclusion, our data demonstrate that B7H1 expression is associated with features of aggressiveness, suggesting that this is an immune evasion mechanism of DTC cells.-
dc.description.sponsorshipState of Sao Paulo Research Foundation (Fapesp) [2009/18362-0, 2011/19681-2]-
dc.language.isoeng-
dc.publisherBIOSCIENTIFICA LTD-
dc.relation.ispartofEndocrine-Related Cancer-
dc.rightsrestrictedAccess-
dc.subjectDifferentiated thyroid carcinoma-
dc.subjecttumor immunology-
dc.subjectB7H1-
dc.subjectprognosis-
dc.subject.otherfoxp3 expression-
dc.subject.otherb7-h1 expression-
dc.subject.othert-cells-
dc.subject.otherbreast-cancer-
dc.subject.othertumor-
dc.subject.otherinterleukin-10-
dc.subject.otherinfiltration-
dc.subject.otherlymphocytes-
dc.subject.othermechanism-
dc.subject.otherevasion-
dc.titleDifferentiated thyroid carcinomas may elude the immune system by B7H1 upregulation-
dc.typearticle-
dc.rights.holderCopyright BIOSCIENTIFICA LTD-
dc.identifier.doi10.1530/ERC-12-0313-
dc.identifier.pmid23193072-
dc.subject.wosOncology-
dc.subject.wosEndocrinology & Metabolism-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalCUNHA, Lucas Leite:Univ Campinas Unicamp, Fac Med Sci, Lab Canc Mol Genet, Sao Paulo, Brazil-
hcfmusp.author.externalMARCELLO, Marjory Alana:Univ Campinas Unicamp, Fac Med Sci, Lab Canc Mol Genet, Sao Paulo, Brazil-
hcfmusp.author.externalMORARI, Elaine Cristina:Univ Campinas Unicamp, Fac Med Sci, Lab Canc Mol Genet, Sao Paulo, Brazil-
hcfmusp.author.externalNONOGAKI, Suely:Adolfo Lutz Inst, Sao Paulo, Brazil-
hcfmusp.author.externalCONTE, Fabio Frangiotti:Univ Campinas Unicamp, Dept Genet & Evolut, Sao Paulo, Brazil-
hcfmusp.author.externalSOARES, Fernando Augusto:AC Camargo Canc Hosp, Dept Pathol, Sao Paulo, Brazil-
hcfmusp.author.externalVASSALLO, Jose:AC Camargo Canc Hosp, Dept Pathol, Sao Paulo, Brazil; Univ Campinas Unicamp, Fac Med Sci, Lab Invest & Mol Pathol Ciped, Sao Paulo, Brazil-
hcfmusp.author.externalWARD, Laura Sterian:Univ Campinas Unicamp, Fac Med Sci, Lab Canc Mol Genet, Sao Paulo, Brazil-
hcfmusp.description.beginpage103-
hcfmusp.description.endpage110-
hcfmusp.description.issue1-
hcfmusp.description.volume2013-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000317263200011-
hcfmusp.origem.id2-s2.0-84874055757-
hcfmusp.publisher.cityBRISTOL-
hcfmusp.publisher.countryENGLAND-
hcfmusp.relation.referenceBlank C, 2006, INT J CANCER, V119, P317, DOI 10.1002/ijc.21775-
hcfmusp.relation.referenceCao YJ, 2011, CANCER RES, V71, P4737, DOI 10.1158/0008-5472.CAN-11-0527-
hcfmusp.relation.referenceCao YJ, 2011, CANCER RES, V71, P1235, DOI 10.1158/0008-5472.CAN-10-2217-
hcfmusp.relation.referenceChen J, 2012, CANCER IMMUNOL IMMUN, V61, P101, DOI 10.1007/s00262-011-1094-3-
hcfmusp.relation.referenceCooper DS, 2009, THYROID, V19, P1167, DOI 10.1089/thy.2009.0110-
hcfmusp.relation.referenceCunha LL, 2012, ENDOCR-RELAT CANCER, V19, pL31, DOI 10.1530/ERC-11-0285-
hcfmusp.relation.referenceCunha LL, 2011, CLINICS, V66, P1203, DOI 10.1590/S1807-59322011000700014-
hcfmusp.relation.referenceCunha LL, 2012, EUR ARCH OTO-RHINO-L, V269, P699, DOI 10.1007/s00405-011-1764-y-
hcfmusp.relation.referenceCunha LL, 2012, CLINICS, V67, P483, DOI 10.6061/clinics/2012(05)13-
hcfmusp.relation.referenceDong HD, 1999, NAT MED, V5, P1365-
hcfmusp.relation.referenceDong HD, 2002, NAT MED, V8, P793, DOI 10.1038/nm730-
hcfmusp.relation.referenceFrench JD, 2010, J CLIN ENDOCR METAB, V95, P2325, DOI 10.1210/jc.2009-2564-
hcfmusp.relation.referenceFrench JD, 2012, J CLIN ENDOCR METAB, V97, pE934, DOI 10.1210/jc.2011-3428-
hcfmusp.relation.referenceGadiot J, 2011, CANCER-AM CANCER SOC, V117, P2192, DOI 10.1002/cncr.25747-
hcfmusp.relation.referenceGogali F, 2012, J CLIN ENDOCR METAB, V97, P1474, DOI 10.1210/jc.2011-1838-
hcfmusp.relation.referenceHanahan D, 2011, CELL, V144, P646, DOI 10.1016/j.cell.2011.02.013-
hcfmusp.relation.referenceHino R, 2010, CANCER-AM CANCER SOC, V116, P1757, DOI 10.1002/cncr.24899-
hcfmusp.relation.referenceHinz S, 2007, CANCER RES, V67, P8344, DOI 10.1158/0008-5472.CAN-06-3304-
hcfmusp.relation.referenceHua D, 2012, WORLD J GASTROENTERO, V18, P971, DOI 10.3748/wjg.v18.i9.971-
hcfmusp.relation.referenceKaiser AD, 2012, EUR J IMMUNOL, V42, P662, DOI 10.1002/eji.201141931-
hcfmusp.relation.referenceKasagi K, 1996, THYROID, V6, P445, DOI 10.1089/thy.1996.6.445-
hcfmusp.relation.referenceKinter AL, 2008, J IMMUNOL, V181, P6738-
hcfmusp.relation.referenceMerlo A, 2009, J CLIN ONCOL, V27, P1746, DOI 10.1200/JCO.2008.17.9036-
hcfmusp.relation.referenceMinot DM, 2009, AM J CLIN PATHOL, V132, P133, DOI 10.1309/AJCPJV0SKAF2PCMY-
hcfmusp.relation.referenceMorari EC, 2010, ENDOCR PATHOL, V21, P242, DOI 10.1007/s12022-010-9137-4-
hcfmusp.relation.referenceMorari EC, 2011, CLIN ENDOCRINOL, V75, P247, DOI 10.1111/j.1365-2265.2011.04032.x-
hcfmusp.relation.referenceRouth JC, 2008, J UROLOGY, V179, P1954, DOI 10.1016/j.juro.2008.01.056-
hcfmusp.relation.referenceShaha AR, 2007, WORLD J SURG, V31, P879, DOI 10.1007/s00268-006-0864-0-
hcfmusp.relation.referenceTaube JM, 2012, SCI TRANSL MED, V4, P127, DOI 10.1126/SCITRANSLMED.3003689)-
hcfmusp.relation.referenceWaeckerle-Men Y, 2007, NEPHROL DIAL TRANSPL, V22, P1527, DOI 10.1093/ndt/gfl818-
hcfmusp.relation.referenceWang LC, 2010, WORLD J SURG, V34, P1059, DOI 10.1007/s00268-010-0448-x-
hcfmusp.relation.referenceWolfle SJ, 2011, EUR J IMMUNOL, V41, P413, DOI 10.1002/eji.201040979-
hcfmusp.relation.referenceYao Y, 2009, NEURO-ONCOLOGY, V11, P757, DOI 10.1215/15228517-2009-014-
dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.citation.scopus74-
hcfmusp.scopus.lastupdate2024-03-08-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_GERHARD_Differentiated_thyroid_carcinomas_may_elude_the_immune_system_2013.PDF
  Restricted Access
publishedVersion (English)215.42 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.