Galectin-3 expression: a useful tool in the differential diagnosis of posterior fossa tumors in children

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author BORGES, Carolina Bisinoto
BERNARDES, Emerson Soares
LATORRACA, Elder Francisco
BECKER, Aline Paixao
NEDER, Luciano
CHAMMAS, Roger FMUSP-HC
ROQUE-BARREIRA, Maria Cristina
MACHADO, Helio Rubens
OLIVEIRA, Ricardo Santos de
dc.date.issued 2011
dc.identifier.citation CHILDS NERVOUS SYSTEM, v.27, n.2, p.253-257, 2011
dc.identifier.issn 0256-7040
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/22908
dc.description.abstract Galectin-3 (Gal-3) is a glycan-binding protein highly expressed in several tumors, including brain neoplasms. This protein has been demonstrated to be correlated with adverse prognosis in some tumor types. However, the role of Gal-3 in pediatric posterior fossa tumors (PPFTs) has not yet been fully addressed. The goals of this study were to evaluate Gal-3 expression in a series of PPFTs and verify whether this expression is related to patient outcome. Gal-3 expression was analyzed by immunohistochemistry in 42 cases of surgically resected primary PPFTs. Surgeries were performed in our institution from January 2003 to December 2006. Tumor samples consisted of 21 pilocytic astrocytomas (PAs), 13 medulloblastomas, 4 ependymomas, 2 diffuse cerebellar astrocytomas, and 2 atypical teratoid/rhabdoid tumors (AT/RTs). All PAs and ependymomas strongly showed Gal-3 expression, whereas no immunostaining was observed in medulloblastomas and diffuse astrocytomas. In AT/RTs, Gal-3 expression was conspicuous but heterogeneous, being mainly observed in rhabdoid cells. Concerning the Gal-3 expressing tumors, no relationship was observed between the degree of expression and patient survival. Gal-3 was strongly expressed in reactive astrocytes, normal endothelial cells, and macrophages in the adjacent non-neoplastic brain parenchyma. Interestingly, the endothelial cells in the tumor bulk of PAs lacked Gal-3 expression. Gal-3 is differentially expressed in PPFTs, but its expression shows no correlation with patient outcome. However, the evaluation of Gal-3 is helpful in establishing a differential diagnosis among PPFTs, especially between PAs and diffuse astrocytomas, and in some circumstances between medulloblastomas and AT/RTs.
dc.description.sponsorship · FAPESP, Fundacao de Apoio a Pesquisa do Estado de Sao Paulo [2009/08497-6, 2006/60642-2]
dc.language.iso eng
dc.publisher SPRINGER
dc.relation.ispartof Childs Nervous System
dc.rights restrictedAccess
dc.subject Brain tumor; Pediatric neurosurgery; Posterior fossa tumors; Galectin-3; Glioma
dc.subject.other central-nervous-system; pilocytic astrocytomas; prostate-cancer; progression; apoptosis
dc.title Galectin-3 expression: a useful tool in the differential diagnosis of posterior fossa tumors in children
dc.type article
dc.rights.holder Copyright SPRINGER
dc.description.group LIM/24
dc.identifier.doi 10.1007/s00381-010-1262-3
dc.identifier.pmid 20711594
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author CHAMMAS, Roger:FM:MDR
hcfmusp.author.external · BORGES, Carolina Bisinoto:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Cell & Mol Biol & Pathogen Bioagents, BR-14049900 Ribeirao Preto, Brazil
· BERNARDES, Emerson Soares:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Cell & Mol Biol & Pathogen Bioagents, BR-14049900 Ribeirao Preto, Brazil
· LATORRACA, Elder Francisco:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol, BR-14049900 Ribeirao Preto, Brazil
· BECKER, Aline Paixao:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol, BR-14049900 Ribeirao Preto, Brazil
· NEDER, Luciano:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol, BR-14049900 Ribeirao Preto, Brazil
· ROQUE-BARREIRA, Maria Cristina:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Cell & Mol Biol & Pathogen Bioagents, BR-14049900 Ribeirao Preto, Brazil
· MACHADO, Helio Rubens:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Surg & Anat, Div Pediat Neurosurg, BR-14049900 Ribeirao Preto, Brazil
· OLIVEIRA, Ricardo Santos de:Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Surg & Anat, Div Pediat Neurosurg, BR-14049900 Ribeirao Preto, Brazil
hcfmusp.origem.id WOS:000286324500011
hcfmusp.origem.id 2-s2.0-78951481494
hcfmusp.publisher.city NEW YORK
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 7
hcfmusp.affiliation.country Brasil
hcfmusp.scopus.lastupdate 2021-08-27


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