Lactate and base deficit are predictors of mortality in critically ill patients with cancer

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author HAJJAR, Ludhmila Abrahao FMUSP-HC
NAKAMURA, Rosana Ely FMUSP-HC
ALMEIDA, Juliano Pinheiro de FMUSP-HC
FUKUSHIMA, Julia T. FMUSP-HC
HOFF, Paulo Marcelo Gehm FMUSP-HC
VINCENT, Jean-Louis
AULER JUNIOR, Jose Otavio Costa FMUSP-HC
GALAS, Filomena Regina Barbosa Gomes FMUSP-HC
dc.date.issued 2011
dc.identifier.citation CLINICS, v.66, n.12, p.2037-2042, 2011
dc.identifier.issn 1807-5932
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/22912
dc.description.abstract OBJECTIVE: Cancer patients frequently require admission to intensive care unit. However, there are a few data regarding predictive factors for mortality in this group of patients. The aim of this study was to evaluate whether arterial lactate or standard base deficit on admission and after 24 hours can predict mortality for patients with cancer. METHODS: We evaluated 1,129 patients with severe sepsis, septic shock, or postoperative after high-risk surgery. Lactate and standard base deficit collected at admission and after 24 hours were compared between survivors and non-survivors. We evaluated whether these perfusion markers are independent predictors of mortality. RESULTS: There were 854 hospital survivors (76.5%). 24 h lactate > 1.9 mmol/L and standard base deficit < -2.3 were independent predictors of intensive care unit mortality. 24 h lactate > 1.9 mmol/L and 24 h standard base deficit, -2.3 mmol/Lwere independent predictors of hospital death. CONCLUSION: Our findings suggest that lactate and standard base deficit measurement should be included in the routine assessment of patients with cancer admitted to the intensive care unit with sepsis, septic shock or after high-risk surgery. These markers may be useful in the adequate allocation of resources in this population.
dc.language.iso eng
dc.publisher HOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartof Clinics
dc.rights openAccess
dc.subject Lactate; Mortality; Cancer; Critical Care
dc.subject.other severe sepsis; septic shock; intensive-care; organ failure; multicenter; admission; severity; acidosis; trial; icu
dc.title Lactate and base deficit are predictors of mortality in critically ill patients with cancer
dc.type article
dc.rights.holder Copyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.description.group LIM/08
dc.description.group LIM/24
dc.identifier.doi 10.1590/S1807-59322011001200007
dc.identifier.pmid 22189727
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author HAJJAR, Ludhmila Abrahao:HC:INCOR
hcfmusp.author NAKAMURA, Rosana Ely:HC:ICESP
hcfmusp.author ALMEIDA, Juliano Pinheiro de:HC:ICESP
hcfmusp.author FUKUSHIMA, Julia T.:HC:ICESP
hcfmusp.author HOFF, Paulo Marcelo Gehm:FM:MDR
hcfmusp.author AULER JUNIOR, Jose Otavio Costa:FM:MCG
hcfmusp.author GALAS, Filomena Regina Barbosa Gomes:HC:ICESP
hcfmusp.author.external · VINCENT, Jean-Louis:Univ Libre Bruxelles, Erasme Hosp, Dept Intens Care, Brussels, Belgium
hcfmusp.origem.id WOS:000298331400007
hcfmusp.origem.id 2-s2.0-84455163502
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 20
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Bélgica
hcfmusp.scopus.lastupdate 2021-08-27


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