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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDANTAS, Wagner Silva-
dc.contributor.authorGUALANO, Bruno-
dc.contributor.authorROCHA, Michele Patrocinio-
dc.contributor.authorBARCELLOS, Cristiano Roberto Grimaldi-
dc.contributor.authorYANCE, Viviane dos Reis Vieira-
dc.contributor.authorMARCONDES, Jose Antonio Miguel-
dc.identifier.citationSCIENTIFIC WORLD JOURNAL, article ID 178364, 7p, 2013-
dc.description.abstractPolycystic ovary syndrome is a complex hormonal disorder affecting the reproductive and metabolic systems with signs and symptoms related to anovulation, infertility, menstrual irregularity and hirsutism. Skeletal muscle plays a vital role in the peripheral glucose uptake. Since PCOS is associated with defects in the activation and pancreatic dysfunction of beta-cell insulin, it is important to understand the molecular mechanisms of insulin resistance in PCOS. Studies of muscle tissue in patients with PCOS reveal defects in insulin signaling. Muscle biopsies performed during euglycemic hyperinsulinemic clamp showed a significant reduction in glucose uptake, and insulin-mediated IRS-2 increased significantly in skeletal muscle. It is recognized that the etiology of insulin resistance in PCOS is likely to be as complicated as in type 2 diabetes and it has an important role in metabolic and reproductive phenotypes of this syndrome. Thus, further evidence regarding the effect of nonpharmacological approaches (e.g., physical exercise) in skeletal muscle of women with PCOS is required for a better therapeutic approach in the management of various metabolic and reproductive problems caused by this syndrome.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/02827-7, 2012/14650-4]-
dc.relation.ispartofScientific World Journal-
dc.subject.otherimpaired glucose-tolerance-
dc.subject.otherpioglitazone treatment-
dc.subject.otherandrogen excess-
dc.titleMetabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue-
dc.subject.wosMultidisciplinary Sciences-
dc.type.versionpublishedVersion-, Wagner Silva:Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, BR-05508030 Sao Paulo, Brazil-, Bruno:Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, BR-05508030 Sao Paulo, Brazil-, Michele Patrocinio:Univ Sao Paulo, Div Endocrinol, Sch Med, BR-05508030 Sao Paulo, Brazil-, Cristiano Roberto Grimaldi:Univ Sao Paulo, Div Endocrinol, Sch Med, BR-05508030 Sao Paulo, Brazil-
hcfmusp.publisher.cityNEW YORK-
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