Transdural motor cortex stimulation reverses neuropathic pain in rats: A profile of neuronal activation

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author PAGANO, Rosana L.
ASSIS, Danielle V.
CLARA, Joseph A.
ALVES, Adilson S.
DALE, Camila S.
TEIXEIRA, Manoel J. FMUSP-HC
FONOFF, Erich T. FMUSP-HC
BRITTO, Luiz R.
dc.date.issued 2011
dc.identifier.citation EUROPEAN JOURNAL OF PAIN, v.15, n.3, 2011
dc.identifier.issn 1090-3801
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23131
dc.description.abstract Motor cortex stimulation (MCS) has been used to treat patients with neuropathic pain resistant to other therapeutic approaches; however, the mechanisms of pain control by MCS are still not clearly understood. We have demonstrated that MCS increases the nociceptive threshold of naive conscious rats, with opioid participation. In the present study, the effect of transdural MCS on neuropathic pain in rats subjected to chronic constriction injury of the sciatic nerve was investigated. In addition, the pattern of neuronal activation, evaluated by Fos and Zif268 immunolabel, was performed in the spinal cord and brain sites associated with the modulation of persistent pain. MCS reversed the mechanical hyperalgesia and allodynia induced by peripheral neuropathy. After stimulation, Fos immunoreactivity (Fos-IR) decreased in the dorsal horn of the spinal cord and in the ventral posterior lateral and medial nuclei of the thalamus, when compared to animals with neuropathic pain. Furthermore, the MCS increased the Fos-IR in the periaqueductal gray, the anterior cingulate cortex and the central and basolateral amygdaloid nuclei. Zif268 results were similar to those obtained for Fos, although no changes were observed for Zif268 in the anterior cingulate cortex and the central amygdaloid nucleus after MCS. The present findings suggest that MCS reverts neuropathic pain phenomena in rats, mimicking the effect observed in humans, through activation of the limbic and descending pain inhibitory systems. Further investigation of the mechanisms involved in this effect may contribute to the improvement of the clinical treatment of persistent pain.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
· Hospital Sirio-Libanes
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.language.iso eng
dc.publisher ELSEVIER SCI LTD
dc.relation.ispartof European Journal of Pain
dc.rights restrictedAccess
dc.subject Motor cortex stimulation; Neuropathic pain; Fos; Zif268; Rats
dc.subject.other anterior cingulate cortex; chronic constriction injury; immediate-early genes; dorsal-horn neurons; lumbar spinal-cord; c-fos expression; electrical-stimulation; transcription factors; sciatic-nerve; peripheral mononeuropathy
dc.title Transdural motor cortex stimulation reverses neuropathic pain in rats: A profile of neuronal activation
dc.type article
dc.rights.holder Copyright ELSEVIER SCI LTD
dc.description.group LIM/26
dc.identifier.doi 10.1016/j.ejpain.2010.08.003
dc.identifier.pmid 20817578
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author TEIXEIRA, Manoel J.:FM:MNE
hcfmusp.author FONOFF, Erich T.:HC:IPQ
hcfmusp.author.external · PAGANO, Rosana L.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil; Hosp Sirio Libanes, Lab Neuromodulat & Expt Pain, Sao Paulo, Brazil
· ASSIS, Danielle V.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil; Hosp Sirio Libanes, Lab Neuromodulat & Expt Pain, Sao Paulo, Brazil
· CLARA, Joseph A.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil; Christian Bros Univ, Minor Hlth Int Res & Training Program, Memphis, TN USA
· ALVES, Adilson S.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil
· DALE, Camila S.:Hosp Sirio Libanes, Lab Neuromodulat & Expt Pain, Sao Paulo, Brazil
· BRITTO, Luiz R.:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000288012700006
hcfmusp.origem.id 2-s2.0-79952453674
hcfmusp.publisher.city OXFORD
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 56
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos
hcfmusp.scopus.lastupdate 2021-08-27


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